Similar studies for GEO DataSets (Select 200099777) - GEO DataSets

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Items: 20

Select item 2000997771.

Expression data of adult quiescent and activated mouse neural stem cells

(Submitter supplied) Neural stem cells were sorted according to their activated or quiescent state by flow cytometry using a set of 3 markers (LeX, CD24 and EGFR) We used microarrays to detail the global programme of gene expression underlying the proliferation/quiescence balance.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
12 Samples

Download data: CEL

Series

Accession:: GSE99777

ID:: 200099777

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001681892.

LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells

(Submitter supplied) Adult neural stem cells (NSCs) must tightly regulate quiescence and proliferation. Single cell analysis has suggested a continuum of cell states as NSCs exit quiescence. Here we capture and characterize in vitro primed quiescent NSCs and identify LRIG1 as an important regulator. We show that BMP-4 signaling induces a dormant non-cycling quiescent state (d-qNSCs), whereas combined BMP-4/FGF-2 signalling induces a distinct primed quiescent state poised for cell cycle re-entry. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23479
12 Samples

Download data: TXT

Series

Accession:: GSE168189

ID:: 200168189

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001612763.

Live imaging in freely behaving mice reveals that adult neural stem cell activation is regulated by the day/night cycle and intracellular Ca2+ dynamic

(Submitter supplied) We compared transcriptome of qNSCs and aNSCs

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: TSV

Series

Accession:: GSE161276

ID:: 200161276

PubMed Similar studies SRA Run Selector

Select item 2001156264.

Aging retains neural stem cells in a dormant state

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL21103 GPL13112 GPL21493
170 Samples

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Series

Accession:: GSE115626

ID:: 200115626

PubMed Similar studies

Select item 2001156225.

Quiescence modulates stem cell maintenance and regenerative capacity in the aging brain – SMART-seq2

(Submitter supplied) Single cell RNA-seq of neural stem cell and astrocytes from old mice

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL13112 GPL21493
168 Samples

Download data: CSV, XLSX

Series

Accession:: GSE115622

ID:: 200115622

PubMed Similar studies SRA Run Selector

Select item 2001156006.

Quiescence modulates stem cell maintenance and regenerative capacity in the aging brain – 10X Chromium

(Submitter supplied) Single cell RNA-seq of neural stem cells from young and old mice

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
2 Samples

Download data: MTX, TSV

Series

Accession:: GSE115600

ID:: 200115600

PubMed Similar studies SRA Run Selector

Select item 2001098177.

RNA-sequencing of mouse adult hippocampal progenitor cells in which Nfix was deleted.

(Submitter supplied) RNA-sequencing of mouse adult hippocampal nestin+ progenitor cells & dcx+ progenitor cells from wild-type animals, and animals in which the gene Nfix was deleted.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
12 Samples

Download data: XLS

Series

Accession:: GSE109817

ID:: 200109817

PubMed Similar studies SRA Run Selector

Select item 2001115278.

Single-cell transcriptomics characterizes cell types in the subventricular zone and uncovers molecular defects impairing adult neurogenesis.

(Submitter supplied) Neural stem cells (NSCs) contribute to plasticity and repair of the adult brain. Niches harboring NSCs regulate stem cell self-renewal and differentiation. We used comprehensive and untargeted single-cell RNA profiling to generate a molecular cell atlas of the largest germinal region of the adult mouse brain, the subventricular zone (SVZ). We characterized > 20 neural and non-neural cell types and gained insights into the dynamics of neurogenesis by predicting future cell states based on computational analysis of RNA kinetics. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
9 Samples

Download data: TXT

Series

Accession:: GSE111527

ID:: 200111527

PubMed Similar studies SRA Run Selector

Select item 2001907669.

Rb family proteins and Activator E2F family transcription factors are master regulators of the molecular signatures instructing the quiescent and activated adult neural stem cell state

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data

Series

Accession:: GSE190766

ID:: 200190766

PubMed Similar studies

Select item 20019076510.

Rb family proteins are master regulators of the molecular signatures instructing the quiescent and activated adult neural stem cell state

(Submitter supplied) The long-term maintenance of the adult neurogenic niche and neurogenesis is dependent on the proper regulation of entry and exit from quiescence. The dynamic transition from quiescence to activation is a complex process requiring not only precise cell cycle control, but also a co-ordinated phenotypic transition involving transcriptional and morphological changes. Presently, the mechanisms by which such a complex repertoire of factors interact and co-ordinate with the core cell cycle machinery to mediate these critical NSC fate transitions remains unknown. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: CSV

Series

Accession:: GSE190765

ID:: 200190765

PubMed Similar studies

Select item 20019076411.

Activator E2F family transcription factors are master regulators of the molecular signatures instructing the quiescent and activated adult neural stem cell state

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: CSV

Series

Accession:: GSE190764

ID:: 200190764

PubMed Similar studies

Select item 20016157812.

Changing and stable chromatin accessibility supports transcriptional overhaul during neural stem cell activation

(Submitter supplied) Adult neural stem cells are largely quiescent, and require transcriptional reprogramming to re-enter the cell cycle before neurogenesis. However, mechanisms underlying the transcriptional overhaul during NSC activation remain undefined. Here, we identify the chromatin accessibility differences between primary neural stem/progenitor cells in quiescent and activated states. These distinct cellular states exhibit shared and unique chromatin profiles, both associated with gene regulation. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
10 Samples

Download data: BEDGRAPH, BROADPEAK, NARROWPEAK

Series

Accession:: GSE161578

ID:: 200161578

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20020015913.

SETD4 Cells Contribute to Brain Development and Maintain Adult Stem Cell Reservoir for Neurogenesis

(Submitter supplied) Cellular quiescence facilitates maintenance of neural stem cells (NSCs) and their subsequent regenerative functions in response to brain injury and aging. However, the specification and maintenance of NSCs in quiescence from embryo to adulthood remains largely unclear. Here, using Set domain-containing protein 4 (SETD4), an epigenetic determinant of cellular quiescence, we mark a small but long-lived NSC population in deep quiescence in the subventricular zone of adult murine brain. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: TXT

Series

Accession:: GSE200159

ID:: 200200159

PubMed Full text in PMC Similar studies

Select item 20008230814.

Expression data from whole lateral ventricle choroid plexus tissue of young (two months old) and aged (eighteen months old) CD1 male mice.

(Submitter supplied) We used microarrays to reveal the global expression profiles of young and old whole lateral ventricle choroid plexus tissue.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE82308

ID:: 200082308

Select item 20008174515.

Profiling of Pol II occupancy in quiescent neural stem cells in Drosophila melanogaster

(Submitter supplied) Pol II profiling of Drosophila quiescent neural stem cells using Targeted DamID (Southall et al. 2013).

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL15641
2 Samples

Download data: GFF, PAIR

Series

Accession:: GSE81745

ID:: 200081745

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006597016.

Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy

(Submitter supplied) The adult mouse subependymal zone (SEZ) provides a niche for mammalian neural stem cells (NSCs). However, the molecular signature, self-renewal potential and fate behavior of NSCs remain poorly defined. Here we propose a model in which the fate of active NSCs is coupled to the total number of neighboring NSCs in a shared niche. Using knock-in reporter alleles and single-cell RNA sequencing, we show that the Wnt target Tnfrsf19/Troy identifies both active and quiescent NSCs. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
28 Samples

Download data: CSV

Series

Accession:: GSE65970

ID:: 200065970

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009499117.

Dynamic control of translation during adult neurogenesis

(Submitter supplied) Here we applied RNAseq and RIBOseq, the deep sequencing of ribosome-associated transcripts, to investigate the relation of RNA abundance and translation at four stages of neurogenic differentiation.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL13112
27 Samples

Download data: TXT

Series

Accession:: GSE94991

ID:: 200094991

PubMed Similar studies SRA Run Selector

Select item 20011176518.

RNA seq analysis on zebrafish Notch 3 mutants and adult neural stem cells

(Submitter supplied) The goal of this study is to identify the Notch3 targets directly responsible for maintaining the quiescent state and the stemness of adult pallial zebrafish Radial Glia.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20828
15 Samples

Download data: TXT

Series

Accession:: GSE111765

ID:: 200111765

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013824319.

SEZ cells populations

(Submitter supplied) Characterization of neural stem cells (NSC) from the adult rodent subependymal niche by flow cytometry and traceable nucleoside retention assays have indicated the co-existence of activated and quiescent NSC in this niche. Single-cell deep-sequencing has further revealed different NSC molecular states with regards to cell-cycle gene expression: quiescent, primed for activation, and fully activated. Here, we provide a multi-level procedure to classify all cells of the subependymal niche, without the need for reporter mice, into populations with coherent transcriptomes that can be functionally assayed. Our strategy reveals that primed NSC are slowly proliferating cells that contribute to NSC cultures and that neurospheres contain NSC which retain a primed-like molecular signature and exhibit slow cycling and long-term self-renewal. Our strategy provides a way to functionally assay NSC heterogeneity and to study quiescence levels in NSC populations.