Similar studies for GEO DataSets (Select 200086593) - GEO DataSets

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Items: 13

Select item 2000865931.

Transcriptomic assessment of PCB-resistance in Atlantic killifish (Fundulus heteroclitus) embryos from a marine Superfund site

(Submitter supplied) RNA from PCB-126 exposed 10 days post-fertilization (dpf) embryos were sequenced to characterize the chemical exposure response of killifish from a PCB-resistant population (NBH, New Bedford Harbor, MA, Superfund site) as compared to a reference (SC, Scorton Creek, MA) population. Since the genome sequence was not available, we also performed shot-gun sequencing of RNA from 1-15 dpf embryos sampled every day from both populations to serve as a transcriptome assembly. more...

Organism:: Fundulus heteroclitus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL22406
6 Samples

Download data: FNA, XLSX

Series

Accession:: GSE86593

ID:: 200086593

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000252452.

Transcriptomic assessment of resistance to effects of an aryl hydrocarbon receptor (AHR) agonist in embryos of Atlantic killifish (Fundulus heteroclitus) from a marine Superfund site

(Submitter supplied) This study presents statistical analyses of gene expression in 5, 10 and 15 day post-fertilization (dpf) embryos of the teleost Fundulus heteroclitus treated with control vehicle (DMSO) or a potent non-ortho-PCB (PCB-126; 3,3’,4,4’,5-pentachlorobiphenyl). The embryos were from two populations: a clean, reference population (SC, Scorton Creek, MA USA) and a polluted Superfund population (N, New Bedford Harbor, MA USA). more...

Organism:: Fundulus heteroclitus

Type:: Expression profiling by array

Platform:: GPL10430
72 Samples

Download data: TXT

Series

Accession:: GSE25245

ID:: 200025245

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000987413.

Early life exposure to low levels of AHR agonist 3,3’,4,4’,5-pentachlorobiphenyl (PCB126) reprograms gene expression in adult brain.

(Submitter supplied) There is growing evidence from epidemiological and experimental studies suggesting that early life exposure to environmental chemicals can have long-term consequences that are seen in adults and not apparent early in life. We recently demonstrated that developmental exposure of zebrafish embryos to low, non-embryotoxic levels of PCB126 did not affect larval behavior but caused changes in adult behavior (Glazer et al., 2016, NeuroToxicology 52:134-143). more...

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18413
24 Samples

Download data: TXT

Series

Accession:: GSE98741

ID:: 200098741

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001189554.

RNAseq of zebrafish (Danio rerio) developmentally exposed to the polychlorinated biphenyl 3,3'-dichlorobiphenyl (PCB-11)

(Submitter supplied) 3,3’-Dichlorobiphenyl (PCB-11) is a non-legacy PCB congener widely detected in environmental samples and has been detected in human serum, but its toxicity potential is poorly understood. Zebrafish statically exposed to 4,500 µg/L PCB-11 at 24 hours post fertilization (hpf) were collected at 96 hpf for RNA sequencing.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20828
6 Samples

Download data: BW, FPKM_TRACKING, TXT

Series

Accession:: GSE118955

ID:: 200118955

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Select item 2001163935.

Screening an alternative flame retardant using biological and transcriptomic endpoints in fish embryos

(Submitter supplied) Although alternative Flame Retardant (FR) chemicals are expected to be safer than the legacy FRs they replace, their risks to human health and the environment are often poorly characterized. This study used a small volume, fish embryo system to reveal potential mechanisms of action and diagnostic exposure patterns for TBPH (bis (2-ethylhexyl)-tetrabromophthalate), a component of several widely-used commercial products. more...

Organism:: Fundulus heteroclitus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25254
48 Samples

Download data: TXT

Series

Accession:: GSE116393

ID:: 200116393

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000145556.

Divergent Transcriptomic Responses to Aryl Hydrocarbon Receptor Agonists Between Rat and Human Primary Hepatocytes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Rattus norvegicus

Type:: Expression profiling by array

Platforms:: GPL96 GPL85
66 Samples

Download data: CEL

Series

Accession:: GSE14555

ID:: 200014555

Select item 2000145547.

Toxicogenomic Comparison of TCDD and PCB 126 Responsiveness in Primary Rat Hepatocytes

(Submitter supplied) (Abstract) Toxicogenomics has great potential for enhancing our understanding of environmental chemical toxicity, hopefully leading to better-informed human health risk assessments. This study employed toxicogenomic technology to reveal species differences in response to two prototypical aryl hydrocarbon receptor (AHR) agonists, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the polychlorinated biphenyl (PCB) congener PCB 126. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL85
26 Samples

Download data: CEL

Series

Accession:: GSE14554

ID:: 200014554

Select item 2000145538.

Toxicogenomic Comparison of TCDD and PCB 126 Responsiveness in Primary Human Hepatocytes

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
40 Samples

Download data: CEL

Series

Accession:: GSE14553

ID:: 200014553

Select item 2000194249.

A rapid transcriptome response is associated with desiccation resistance in aerially-exposed killifish embryos

(Submitter supplied) The changes in the transcriptome of Fundulus heteroclitus embryos incubated in water or in air from the blastula stage was investigated.

Organism:: Fundulus heteroclitus

Type:: Expression profiling by array

Platform:: GPL9786
42 Samples

Download data: TXT

Series

Accession:: GSE19424

ID:: 200019424

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Select item 20002997610.

Fundulus exposed to arsenic as embryos

(Submitter supplied) The present study used microarray expression profiling to determine the effects of embryonic arsenic exposure. Fertilized killifish (Fundulus heteroclitus) eggs were exposed to 0, 5, 15, or 25ppm arsenic as sodium arsenite. To examine differentially expressed genes, the microarrays were probed using RNA obtained from the control and 25ppm-exposed killifish just after hatching. No differences were noted in survival or hatching success between any of the groups. more...

Organism:: Fundulus heteroclitus

Type:: Expression profiling by array

Platform:: GPL13723
20 Samples

Download data: TXT

Series

Accession:: GSE29976

ID:: 200029976

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Select item 20013450111.

Pollution Effects on Metabolic Gene Expression During Late Organodifferenatiation of Sensitive, Resistant and Hybrid Vertebrate Embryos

(Submitter supplied) The goal was to determine differences in gene expression of 384 metabolic genes during late organogenesis among embryos of parents from a clean site (Magotha Bay, VA) and polluted site (Elizabeth RIver, VA). Hybrid gene expression was examined to explore parental effect. Embryo morphology and heart rate during late organogenesis and pre-hatching was assessed in order to determine phenotypic differences between embryo groups.

Organism:: Fundulus heteroclitus

Type:: Expression profiling by array

Platform:: GPL26931
40 Samples

Download data: TXT

Series

Accession:: GSE134501

ID:: 200134501

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Select item 20015646012.

Transcriptional response to embryonic PCB exposure in 8 killifish populations

(Submitter supplied) Embryos from 8 populations of killifish, four with evolved tolerances, were exposed to PCB-126. Approximately 5 replicate embryos per treatment/control were sequenced. Desensitization of aryl hydrocarbon receptor signaling to PCB-126 is found in all four populations with evolved pollution tolerance, and represents the strongest transcriptional difference between tolerant and sensitive populations.

Organism:: Fundulus heteroclitus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL29035
75 Samples

Download data: TXT

Series

Accession:: GSE156460

ID:: 200156460

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20002137213.

Gene expression throughout vertebrate embryogenesis

(Submitter supplied) This study presents statistical analyses of gene expression during all 40 developmental stages in the teleost Fundulus heteroclitus using four biological replicates per stage. Patterns of gene expression for 7,000 genes appear to be important as they recapitulate developmental timing. Among the 45% of genes with significant expression differences between pairs of temporally adjacent stages, significant differences in gene expression vary from as few as five to more than 660. more...