Similar studies for GEO DataSets (Select 200049840) - GEO DataSets

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Items: 20

Select item 2000498401.

Transcriptomic characterization of the novel avian-origin influenza A (H7N9) virus: specific and intermediate host-response between avian (H5N1 and H7N7) and human (H3N2) viruses.

(Submitter supplied) A novel avian-origin H7N9 influenza A virus (IAV) emerged in China in early 2013 causing mild to lethal human respiratory infections. H7N9 originated from multiple reassortment events between avian viruses and carries genetic markers of human adaptation. Determining whether H7N9 induces a host-response closer to human or avian IAV is important to better characterize this emerging virus. Here we compared the human lung epithelial cell response to infection with A/Anhui/01/13 (H7N9) or highly pathogenic avian-origin H5N1, H7N7, or human seasonal H3N2 IAV.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17077
78 Samples

Download data: TXT

Series

Accession:: GSE49840

ID:: 200049840

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000535232.

Comparative Time Course Profiles of Phthalate Stereoisomers in Mice

(Submitter supplied) Analysis of gene expression level in a mouse tumorigenic phthalate, DEHP vs non-tumorigenic DNOP. The hypothesis tested in the present study was to identify early key event thresholds related to tumor outcomes in a two-year carcinogenicity bioassay. Our results highlight marked differences in the toxicity profiles of structurally similar phthalates and demonstrate quantitative relationships between early bioindicators and later tumor outcomes.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL15097
16 Samples

Download data: TXT

Series

Accession:: GSE53523

ID:: 200053523

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Select item 2000540483.

Characterizing the transcriptomic response of mice infected with A/Anhui/01/2013 (H7N9), A/Netherlands/219/2003 (H7N7), and A/Vietnam/1203/2004 (H5N1), and a pandemic H1N1 human virus, A/Mexico/4482/2007 (H1N1)

(Submitter supplied) Modulating the host response is a promising approach to treating influenza, a virus whose pathogenesis is determined in part by the host response it elicits. Though the pathogenicity of emerging H7N9 influenza virus has been reported in several animal models, these studies have not included a detailed characterization of the host response following infection. To this end, we characterized the transcriptomic response of BALB/c mice infected with H7N9 (A/Anhui/1/2013) virus and compared it to the responses induced by H5N1 (A/Vietnam/1203/2004), H7N7 (A/Netherlands/219/2003) or H1N1 (A/Mexico/4482/2009) viruses. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
68 Samples

Download data: TXT

Series

Accession:: GSE54048

ID:: 200054048

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Select item 2000363284.

IM002, IM009 - Implication of inflammatory macrophages, nuclear receptors and interferon regulatory factors in increased virulence of pandemic 2009 H1N1 influenza A virus after host adaptation

(Submitter supplied) While pandemic 2009 H1N1 influenza A viruses were responsible for numerous severe infections in humans, these viruses do not typically cause corresponding severe disease in mammalian models. However, the generation of a virulent 2009 H1N1 virus following serial lung passage in mice has allowed for the modeling of human lung pathology in this species. Genetic determinants of mouse-adapted 2009 H1N1 viral pathogenicity have been identified, but the molecular and signaling characteristics of the host response following infection with this adapted virus have not been described. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
64 Samples

Download data: TXT

Series

Accession:: GSE36328

ID:: 200036328

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Select item 2001407595.

Viral determinants in H5N1 influenza A virus enable productive infection of HeLa cells

(Submitter supplied) Influenza A virus (IAV) is a human respiratory pathogen that causes yearly global epidemics, and sporadic pandemics due to human adaptation of pathogenic strains. Efficient replication of IAV in different species is, in part, dictated by its ability to exploit the genetic environment of the host cell. To investigate IAV tropism in human cells, we evaluated the replication of IAV strains in a diverse subset of epithelial cell lines. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
8 Samples

Download data: TXT

Series

Accession:: GSE140759

ID:: 200140759

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Select item 2000489766.

Cynomolgus macaque model of H7N9 influenza infection

(Submitter supplied) The objective of this study is to characterize the response to newly emerged, highly pathogenic H7N9 influenza virus isolated from human patients in 2013 in China. This study examines the pathogenesis of H7N9 influenza in cynomolgus macaques. The study compares lung lesions to adjacent right lower lobe lung tissue in animals necropsied at days 3 and 6 post-infection (n=4 animals/timepoint). 3-4 lesions from each animal were collected and equal amounts of pooled RNA from lesions from individual animals at each time point were used for microarray.

Organism:: Macaca mulatta; Macaca fascicularis

Type:: Expression profiling by array

Platform:: GPL17465
24 Samples

Download data: TXT

Series

Accession:: GSE48976

ID:: 200048976

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Select item 2000615177.

Strand-specific Dual RNA-seq of Bronchial Epithelial cells Infected with Influenza A/H3N2 Viruses Reveals Splicing of Gene Segment 6 and Novel Host-Virus Interactions

(Submitter supplied) Host-influenza virus interplay at the transcript level has been extensively characterized in epithelial cells. Yet, there are no studies that simultaneously characterize human host and influenza A virus (IAV) genomes. We infected human bronchial epithelial BEAS-2B cells with two seasonal IAV/H3N2 strains, Brisbane/10/07 and Perth/16/09 (reference strains for past vaccine seasons) and the well-characterized laboratory strain Udorn/307/72. more...

Organism:: Influenza A virus (A/Perth/16/2009(H3N2)); Influenza A virus (A/Udorn/307/1972(H3N2)); Influenza A virus (A/Brisbane/10/2007(H3N2)); Homo sapiens

Type:: Expression profiling by high throughput sequencing

4 related Platforms
36 Samples

Download data: FA, XLSX

Series

Accession:: GSE61517

ID:: 200061517

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000539328.

Expression data of lungs from chickens infected with different H5N1 Avian Influenza Viruses

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Gallus gallus

Type:: Expression profiling by array

Platform:: GPL3213
18 Samples

Download data: CEL

Series

Accession:: GSE53932

ID:: 200053932

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000539319.

Expression data of lungs from chickens infected with different H5N1 Avian Influenza Viruses [24 hours post infection]

(Submitter supplied) Recently, a novel protein in the influenza virus segment 3 has been identified, namely PA-X. This small protein has been reported to play a role in modulating host response of the 1918 H1N1 pandemic virus-infected mice. However, poteinal role of this protein in the pathogenicity and regulating host response of the highly pathogenic H5N1 virus in a chicken animal model is completely unknown. We used microarray analysis to evaluate the global transcriptional response in the lungs of the chickens infected with the parental strain (CK10) and PA-X deficiency mutant strain (CK-PAX3).

Organism:: Gallus gallus

Type:: Expression profiling by array

Platform:: GPL3213
9 Samples

Download data: CEL

Series

Accession:: GSE53931

ID:: 200053931

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Select item 20005393010.

Expression data of lungs from chickens infected with different H5N1 Avian Influenza Viruses [12 hours post infection]

Organism:: Gallus gallus

Type:: Expression profiling by array

Platform:: GPL3213
9 Samples

Download data: CEL

Series

Accession:: GSE53930

ID:: 200053930

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Select item 20010718611.

Microarray analysis of microRNAs expression in A549 cells during influenza A virus infection

(Submitter supplied) To investigate whether influenza A virus (IAV) infection alters cellular miRNA profiles, A549 cells were either mock-infected or infected with two different subtypes of IAV, A/Beijing/501/2009 (H1N1; MOI=5) and A/Vietnam/1194/2004 (H5N1; MOI=2), for 24 or 48 h. Total RNA was purified from cell samples, and microarray analysis of miRNAs was performed. The expression of selected miRNAs was further confirmed by quantitative real-time PCR.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL8179
6 Samples

Download data: IDAT, TXT

Series

Accession:: GSE107186

ID:: 200107186

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Select item 20010708912.

Expression data of mRNA from wild-type A549 cells and microRNA-203 knockout A549 cells during H5N1 infections

(Submitter supplied) MicroRNA-203 was up-regulated markedly upon H5N1 virus infection. To identify the potential target genes of miR-203, we constructed a miR-203 knockout A549 cell line. Then wild-type and miR-203 knockout A549 cells were mock-infected or infected with H5N1 virus for 48h. The Agilent Whole Human Genome Oligo Microarray was performed to analyze the mRNA expression profiling. Meanwhile, the online tool TargetScanHuman (http://www.targetscan.org/vert_71/) was used to predict biological targets of miR-203. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13497
6 Samples

Download data: TXT

Series

Accession:: GSE107089

ID:: 200107089

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Select item 20003152413.

Host cells infected by various types of viruses

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Gallus gallus; Mus musculus; Homo sapiens; Canis lupus familiaris

Type:: Expression profiling by array

4 related Platforms
228 Samples

Download data: CEL, CHP

Series

Accession:: GSE31524

ID:: 200031524

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Select item 20003151814.

Host cell gene expression in Influenza A virus (A/Singapore/478/2009 (pH1N1)) infected A549 cells at 2, 4, 6, 8 and 10 hours post infection

(Submitter supplied) We used the microarray data to analyze host cells response on A549 cells infected with Influenza A virus (A/Singapore/478/2009 (pH1N1))