GEO DataSets

(Submitter supplied) Transcriptional profiling of LVS grown in hepatocytic cell line FL83B was compared to that of LVS cultued in MH broth to discover genes important for intracellular growth.

Organism:

Francisella tularensis subsp. holarctica LVS; Francisella tularensis

Type:

Expression profiling by array

Platform:

GPL4250

4 Samples

Download data: GPR

(Submitter supplied) These microarray studies are part of a larger study characterizing a deletion mutant of the putative transcriptional regulator IclR in Francisella tularensis LVS and SchuS4 strains. The microarrays were performed using RNA isolated from wild-type LVS and a LVS iclR deletion mutant after growing in Chamberlain?s defined media pH 6.3 to early mid-log phase. Results suggest that IclR affects expression of several genes after determining statistically significant differences by SAM.

Organism:

Francisella tularensis

Type:

Expression profiling by array

Platform:

GPL5844

6 Samples

Download data: GPR, MEV

(Submitter supplied) Francisella tularensis is a category A select agent based on its infectivity and virulence but disease mechanisms in F. tularensis infection remain poorly understood. A murine pulmonary model of infection was therefore employed to characterize the host immune response to F. tularensis infection and to discern differences in responses to infection with the highly virulent Type A F. tularensis strain Schu4 and to the less virulent Type B live vaccine strain (LVS). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10504

108 Samples

Download data

(Submitter supplied) Three pairs of total RNA preparations from F. t. LVS grown under iron-replete and iron-restricted conditions were used in the DNA microarray. Seven arrays were used to examine the genes affected by iron limitation. Keywords: Dual Channel (Cy5/Cy3) arrays

Organism:

Francisella tularensis

Type:

Expression profiling by array

Platform:

GPL3078

7 Samples

Download data: TXT

(Submitter supplied) Comparison of expression profiles of strains of Francisella to identify virulence factors We used custom microarrays to detail the global gene expression of four strains of Francisella (Schu4, LVS, OR960246, U112) and identified distinct classes of differentially expressed genes during this process.

Organism:

Francisella; Francisella tularensis subsp. novicida U112; Francisella tularensis subsp. tularensis SCHU S4; Francisella tularensis subsp. holarctica LVS; Francisella tularensis subsp. holarctica OR96246

Type:

Expression profiling by array

Platform:

GPL20119

12 Samples

Download data: CEL

(Submitter supplied) We used transposon insertion sequencing (Tn-Seq) to identify the genes that are required for in vitro growth and intramacrophage growth of the live vaccine strain of F. tularensis (LVS).

Organism:

Francisella tularensis subsp. holarctica LVS

Type:

Other

Platform:

GPL27588

5 Samples

Download data: WIG