Similar studies for GEO DataSets (Select 200042503) - GEO DataSets

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Items: 20

Select item 2000425031.

Timecourse of mCMV Infection of Bone Marrow-Derived Macrophages (BMDMs)

(Submitter supplied) The systematic temporal gene expression analysis of primary macrophages activated under immune (interferon-gamma) and productive viral infection with murine cytomegalovirus (mCMV). The primary objective of the study is to define, in an unbiased manner, cause-and-effect relationships in the program of gene activation in this cellular system. The even spacing and time intervals (every 30 minutes) makes this study amenable to modelling of gene networks in the system.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL891
25 Samples

Download data: TXT

Series

Accession:: GSE42503

ID:: 200042503

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000425052.

Interferon-Gamma- and Murine-CMV-Activated Primary Macrophages

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL891
50 Samples

Download data: TXT

Series

Accession:: GSE42505

ID:: 200042505

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Select item 2000425043.

Timecourse of Interferon-Gamma Treatment of Bone Marrow-Derived Macrophages (BMDMs)

(Submitter supplied) The systematic temporal gene expression analysis of primary macrophages activated under immune (interferon-gamma (IFN-g)) and productive viral infection with murine cytomegalovirus (mCMV). The primary objective of the study is to define, in an unbiased manner, cause-and-effect relationships in the program of gene activation in this cellular system. The even spacing and time intervals (every 30 minutes) makes this study amenable to modelling of gene networks in the system.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL891
25 Samples

Download data: TXT

Series

Accession:: GSE42504

ID:: 200042504

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000540644.

The role of Ch25h in the macrophage response to poly(I:C)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
38 Samples

Download data: TXT

Series

Accession:: GSE54064

ID:: 200054064

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Select item 2000540635.

The role of Ch25h in the macrophage response to poly(I:C) (Let1a)

(Submitter supplied) Cross-talk between sterol regulatory pathways and inflammatory pathways has been demonstrated to play an important role in the response to viral infections. 25-Hydroxycholesterol (25HC) is an oxysterol that plays multiple roles in lipid biosynthesis and immunity, and has recently been shown to have anti-viral activity. Surprisingly, we found that deletion of Ch25h, the gene encoding the enzyme responsible for 25HC production, is protective in a mouse model of influenza infection as a result of decreased inflammatory-induced pathology. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
14 Samples

Download data: TXT

Series

Accession:: GSE54063

ID:: 200054063

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Select item 2000540626.

The role of Ch25h in the macrophage response to poly(I:C) (bone-marrow-derived macrophages)

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
24 Samples

Download data: TXT

Series

Accession:: GSE54062

ID:: 200054062

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Select item 2000414757.

Human primary airway epithelial cell cultures infected with human- and swine-origin influenza viruses

(Submitter supplied) Cultures of primary human airway epithelial cells (HAE cells) were exposed to an MDCK equivalent MOI of 0.01 of several swine- and human-origin influenza viruses and RNA was extracted at the 12, 16, and 24 hours post infection.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16163
64 Samples

Download data: CEL

Series

Accession:: GSE41475

ID:: 200041475

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Select item 2001653288.

25-Hydroxycholesterol Inhibits KSHV and EBV Infections and Activates Inflammatory Cytokines

(Submitter supplied) We previously demonstrated that 25HC (25-hydroxycholesterol, a derivative of cholesterol) blocks KSHV (Kaposi Sarcoma-associated Herpesvirus/ Human Herpesvirus-8) de novo infection of primary endothelial cells at a post-entry step and decreases viral gene expression. Herein we sought to determine transcriptomic changes associated with 25HC treatment of primary endothelial cells and primary B cells using RNA sequencing. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL21290 GPL20301
30 Samples

Download data: TXT

Series

Accession:: GSE165328

ID:: 200165328

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000589939.

RNA-seq of 8hr LPS-stimulated bone marrow-derived macrophages from wild type, Ch25h-deficient, and LXRab knockout mice

(Submitter supplied) 25-hydroxycholesterol has been demonstrated to regulate SREBP processing, yet Ch25h-deficient mice have no cholesterol abnormalities. Using RNA-seq, we find that LPS-stimulated, Ch25h-deficient BMDMs have dysregulated SREBP target genes, demonstrating that 25-hydroxycholesterol is an induced repressor of SREBP during inflammatory settings.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: TXT

Series

Accession:: GSE58993

ID:: 200058993

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20017614610.

Bromodomain protein 9 (BRD9) regulates interferon-stimulated genes during macrophage activation via cooperation with BET protein BRD4

(Submitter supplied) Macrophages induce a number of inflammatory response genes in response to stimulation with microbial ligands. In response to endotoxin Lipid A, lineage-defining and stimulation-responsive transcription factors cooperate to induce a gene activation cascade of primary followed by secondary response genes. Epigenetic state is an important regulator of the kinetics, specificity, and mechanism of gene activation of these two classes. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL21103 GPL19057
104 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE176146

ID:: 200176146

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Select item 20018907911.

Bulk RNA-sequencing in Ldlr-/- or Ch25h-/-;Ldlr-/- peritoneal macrophages treated with LPS

(Submitter supplied) Here we study the effect of LPS in the transcriptome of thioglycollate-elicited peritoneal macrophages isolated from Ldlr knock out and Ch25h;Ldlr double knock out mice

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
18 Samples

Download data: TXT

Series

Accession:: GSE189079

ID:: 200189079

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Select item 20013902712.

Transcriptomics analysis of cells transfected with miR-183 cluster mimics and immunostimulated with poly(I:C)

(Submitter supplied) Our work demonstrated that miR-183 cluster regulates IFN production and signaling We used microarrays to detail the effect of miR-183 cluster on hepatic gene expression during immunostimulation with poly(I:C). Our finding suggests enrichment of pathways involved in IFN production and signaling. Amoung the miR-183 repressed genes, we identifies PPP2CA and TRIM27, which are negative regulators of the innate immune response.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
4 Samples

Download data: CEL, CHP

Series

Accession:: GSE139027

ID:: 200139027

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004333413.

hCAF1/CNOT7 regulates interferon signaling by targeting STAT1

(Submitter supplied) Stringent regulation of the interferon signaling pathway is essential for maintaining the immune response to pathogens and tumors. The transcription factor STAT1 is a crucial mediator of this response. Here we show that hCAF1/CNOT7 regulates class I and II interferon pathways at different crucial steps. In resting cells hCAF1 can control STAT1 trafficking by interacting with the latent form of STAT1 in the cytoplasm. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL5175 GPL5188
12 Samples

Download data: CEL

Series

Accession:: GSE43334

ID:: 200043334

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Select item 20001461214.

Expression data from RAW 264.7 macrophage

(Submitter supplied) IFNg is a pro-inflammatory and pro-atherogenic cytokine that leads to macrophage activation. Adenosine has well-documented anti-inflammatory properties. We used microarrays to compare the global gene expression profile in mouse macrophages stimulated with IFNg alone and those cells treated with IFNg and adenosine. We determined that adenosine suppressed the expression of many IFNg-regulated pro-inflammatory cytokines, chemokines, and other pro-atherogenic genes. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL339
2 Samples

Download data: CEL

Series

Accession:: GSE14612

ID:: 200014612

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Select item 20006329015.

Temporal analysis of RNA turnover in Interferon Gamma treated bone marrow-derived macrophages

(Submitter supplied) Interferon gamma treatment of macrophages results in hundreds if not thousands of alterations in gene expression and an antiviral state being established in these cells. Little is known about relationship between transcript synthesis, abundance and decay in macrophages during the first hours after interferon gamma treatment and how these factors influence the antiviral cellular phenotype. Microarrays were used to analyse alterations in transcript synthesis and abundance in BMDM treated with Interferon Gamma for 8h.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
47 Samples

Download data: CEL

Series

Accession:: GSE63290

ID:: 200063290

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010402716.

Common and differential transcriptional actions of LXRalpha and LXRbeta in murine macrophages

(Submitter supplied) The LXR proteins, LXRα and LXRβ, are transcription factors that belong to the nuclear receptor superfamily. LXRs are activated by oxysterols and control the transcription of genes involved in the regulation of cholesterol and fatty acid metabolism. They also mediate several aspects of macrophage biology, including inflammatory responses, cell survival in response to infection and phagocytosis of apoptotic cells. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
8 Samples

Download data: BEDGRAPH

Series

Accession:: GSE104027

ID:: 200104027

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20000242117.

IFNgamma and 1a,25(OH)2D3 dependent gene expression in bone marrow derived macrophages

(Submitter supplied) Gene expression profiling of macrophages derived from WT and Vdr deficient mice after stimulation with IFNgamma and/or 1alpha,25(OH)2D3 Keywords = macrophages Keywords = VDR Keywords = activated vitamin D3 Keywords = IFNgamma Keywords = KO mice Keywords: dose response

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS1389
Platform:: GPL339
8 Samples

Download data: CEL, CHP, RPT

Series

Accession:: GSE2421

ID:: 200002421

Select item 138918.

1alpha,25-dihydroxyvitamin D3 suppressive effect on IFN-gamma activated macrophages

Analysis of wild type and vitamin D receptor (Vdr) knockout primary bone marrow-derived macrophages following treatment with IFN-gamma and/or 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3). Results indicate that 1alpha,25(OH)2D3 suppresses effector functions of IFN-gamma-activated macrophages.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 4 agent, 2 genotype/variation sets

Platform:: GPL339
Series:: GSE2421
8 Samples

Download data: CEL, CHP, RPT

DataSet

Accession:: GDS1389

ID:: 1389

Select item 20012080819.

Genome-wide collaboration of canonical and non-canonical STAT1 complexes with NF-κB to control signal integration between Interferons and TLR4 in vascular and immune cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL17021
111 Samples

Download data: TDF

Series

Accession:: GSE120808

ID:: 200120808

PubMed Full text in PMC Similar studies

Select item 20012080720.

Genome-wide collaboration of canonical and non-canonical STAT1 complexes with NF-κB to control signal integration between Interferons and TLR4 in vascular and immune cells [RNA-seq]

(Submitter supplied) Atherosclerosis is a disease of large and medium-sized muscular arteries and is characterized by vascular inflammation and lipid-laden plaque formation within the intima of the vessel wall. Atherosclerosis is initiated by recruitment of blood leukocytes to the injured vascular endothelium and leads to altered contractility of Vascular Smooth Muscle Cells (VSMCs), acute and chronic luminal obstruction, abnormalities of blood flow and diminished oxygen supply to target organs. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
81 Samples

Download data

Series

Accession:: GSE120807

ID:: 200120807

PubMed Full text in PMC Similar studies SRA Run Selector

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