Similar studies for GEO DataSets (Select 200023034) - GEO DataSets

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Items: 20

Select item 2000230341.

Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells

(Submitter supplied) Human induced pluripotent stem (iPS) cells are remarkably similar to embryonic stem (ES) cells, but recent reports indicate that there may be important differences between them. We carried out a systematic comparison of human iPS cells generated from hepatocytes (representative of endoderm), skin fibroblasts (mesoderm) and melanocytes (ectoderm). All low-passage iPS cells analysed retain a transcriptional memory of the original cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3867
Platform:: GPL10666
24 Samples

Download data: CEL

Series

Accession:: GSE23034

ID:: 200023034

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 38672.

Comparison of induced pluripotent and embryonic stem cells

Analysis of induced pluripotent stem (iPS) cells from somatic cells (melanocytes, fibroblasts, and hepatocytes) representing all 3 embryonic germ layers, embryonic stem (ES) cell lines (H1, H7, H9) and their embryoid bodies. Results suggest iPS cells retain a memory of the original somatic cells.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 12 cell type, 11 other sets

Platform:: GPL10666
Series:: GSE23034
24 Samples

Download data: CEL

DataSet

Accession:: GDS3867

ID:: 3867

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000186913.

Expression data of embryonal carcinoma (EC) cells derived pluripotent stem cells

(Submitter supplied) EC cells derived pluripotent stem cells could prolong the development of tetraploid aggregated mice; and the increased pluripotecny of EC cells derived pluripotent stem cells coincided with the recovery of many critical genes. Therefore, EC cells derived pluripotent stem cells were really the intermediates between EC cells and ES cells. And they had specific molecular characteristics, which may account for the improved pluripotency observed. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
9 Samples

Download data: CEL

Series

Accession:: GSE18691

ID:: 200018691

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000571794.

Epigenetic and transcriptional aberrations in human pluripotent stem cells reflect differences in reprogramming mechanisms

(Submitter supplied) Human pluripotent stem cells hold great potential for regenerative medicine, but available cell types have important limitations. While embryonic stem cells derived from fertilized embryos (IVF-ESCs) are considered the 'gold standard' of pluripotency, they are allogeneic to potential recipients. Autologous induced pluripotent stem cells (iPSCs) are prone to epigenetic and transcriptional aberrations. more...

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL16791
11 Samples

Download data: TSV

Series

Accession:: GSE57179

ID:: 200057179

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000531415.

Epigenetic and transcriptional aberrations in human pluripotent stem cells reflect differences in reprogramming mechanisms [SNP array]

(Submitter supplied) Human pluripotent stem cells hold great potential for regenerative medicine, but available cell types have important limitations. While embryonic stem cells derived from fertilized embryos (IVF-ESCs) are considered the "gold standard" of pluripotency, they are allogeneic to potential recipients. Autologous induced pluripotent stem cells (iPSCs) are prone to epigenetic and transcriptional aberrations. more...

Organism:: Homo sapiens

Type:: SNP genotyping by SNP array

Platform:: GPL14157
21 Samples

Download data: TXT

Series

Accession:: GSE53141

ID:: 200053141

PubMed Full text in PMC Similar studies

Select item 2000530966.

Epigenetic and transcriptional aberrations in human pluripotent stem cells reflect differences in reprogramming mechanisms

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array; Expression profiling by high throughput sequencing; SNP genotyping by SNP array

Platforms:: GPL13534 GPL14157 GPL11154
56 Samples

Download data

Series

Accession:: GSE53096

ID:: 200053096

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000530947.

Epigenetic and transcriptional aberrations in human pluripotent stem cells reflect differences in reprogramming mechanisms [RNA-Seq]

(Submitter supplied) Human pluripotent stem cells hold great potential for regenerative medicine, but available cell types have important limitations. While embryonic stem cells derived from fertilized embryos (IVF-ESCs) are considered the "gold standard" of pluripotency, they are allogeneic to potential recipients. Autologous induced pluripotent stem cells (iPSCs) are prone to epigenetic and transcriptional aberrations. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
24 Samples

Download data: TXT

Series

Accession:: GSE53094

ID:: 200053094

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000530608.

Epigenetic and transcriptional aberrations in human pluripotent stem cells reflect differences in reprogramming mechanisms [methylation array]

(Submitter supplied) Human pluripotent stem cells hold great potential for regenerative medicine, but existing cell types have imitations. Human embryonic stem cells derived from fertilized embryos (IVF-ESCs) are considered the “gold standard”, but are allogeneic to potential recipients. Autologous induced pluripotent stem cells (iPSCs) can be produced from somatic cells by forced expression of pluripotency-associated factors, but are prone to genetic and epigenetic aberrations. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
11 Samples

Download data: TXT

Series

Accession:: GSE53060

ID:: 200053060

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000137709.

Induction of pluripotent stem cells from adult somatic cells by protein-based dedifferentiation

(Submitter supplied) The concept of dedifferentiation of somatic cells into pluripotent stem cells has opened a new era in regenerative medicine. Viral transduction of defined factors has successfully achieved pluripotency derived from somatic cells. However, during the generation process of induced pluripotent stem (iPS) cells, genetic integration of certain factors may cause mutagenesis or tumorigenicity, which limits further application. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
9 Samples

Download data: CEL, CHP

Series

Accession:: GSE13770

ID:: 200013770

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005223810.

Global indiscriminate methylation in cell-specific gene promoters following reprogramming into human induced pluripotent stem cells

(Submitter supplied) Genome wide DNA methylation profiling of somatic and pluripotent cells from different lineages (mesoderm, endoderm and parthenogenetic germ cells) The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs. Samples included 1 Human ES cell line, 2 beta cells, 2 beta-iPS cells, 1 fibroblast, 2 fibroblast-iPS cells, 2 parthenogenetic cells and 3 parthenogenetic-iPS cells. more...

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
13 Samples

Download data: TXT

Series

Accession:: GSE52238

ID:: 200052238

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002988011.

Expression data from epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells

(Submitter supplied) Three induced pluripotent stem (iPS) cell lines were generated from pancreatic BCD (beta-cell-derived cells). One iPS cell clone was derived from pancreatic non-beta cells. We used microarrays to study the gene expression profiles of beta-iPSCs, and compared the expression of genes in their somatic parental cells and other ES and iPS cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
4 Samples

Download data: CEL

Series

Accession:: GSE29880

ID:: 200029880

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002736212.

Expression data from parthenogenetic and WT iPS samples and their parental fibroblasts

(Submitter supplied) Three parthenogenetic induced pluripotent stem cell (PgHiPSCs) lines were generated from each of the ovarian teratoma cell lines (two distinct individuals). Two normal iPS cell lines were generated from normal fibroblasts. Three biological replicates of normal embryonic stem cells (H9, HESCs) were perfomed. We used microarrays to study the gene expression profiles of the PgHiPSCs, and compared the expression of genes to both embryonic and induced pluripotent stem cell, to identify paternally expressed genes that are down-regulated in the PgHiPSC lines.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
14 Samples

Download data: CEL

Series

Accession:: GSE27362

ID:: 200027362

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001818013.

Generation of human induced pluripotent stem cells from mesenchymal cells of gut mesentery by Oct4/Sox2/Nanog

(Submitter supplied) Background and aim: Human Induced pluripotent stem (iPS) cells have been derived from dermal ﬁbroblasts, keratinocytes and blood cells by ectopic expression of defined transcription factors.1–5 Application of this approach in human cells would have enormous potential and generate patient-specific pluripotent stem cells to accelerate the implementation of stem cells for clinical treatment of degenerative diseases. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
3 Samples

Download data: CEL, CHP, TXT

Series

Accession:: GSE18180

ID:: 200018180

Select item 20000983214.

Reprogramming of human somatic cells to pluripotency with defined factors

(Submitter supplied) Pluripotency, the capacity of embryo-derived stem cells to generate all tissues in the organism, can be induced in somatic cells by nuclear transfer into oocyte, fusion with embryonic stem cells, and for male germ cells by cell culture alone. Recently, murine fibroblasts have been reprogrammed directly to pluripotency by ectopic expression of four transcription factors (Oct4, Sox2, Klf4, and Myc) to yield induced Pluripotent Stem (iPS) cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
16 Samples

Download data: CEL, CHP

Series

Accession:: GSE9832

ID:: 200009832

Select item 20001535515.

Direct Reprogramming of Human Neural Stem Cells by OCT4

(Submitter supplied) Induced pluripotent stem (iPS) cells have been generated from mouse and human somatic cells by ectopic expression of the four transcription factors (OCT4, SOX2, c-MYC, KLF4). We previously reported that Oct4 alone is sufficient to directly reprogram adult mouse neural stem cells (NSCs) to iPS cells. Here, we report the generation of one-factor (1F) human iPS from human NSCs (1F hNiPS) by ectopic expression of Oct4 alone. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6883
10 Samples

Download data: TXT

Series

Accession:: GSE15355

ID:: 200015355

Select item 20001321216.

Global gene-expression analyses of the Esrrb knockdown cells

(Submitter supplied) In the murine system, Oct4, Sox2, c-Myc and Klf4 are sufficient to convert fibroblasts to induced pluripotent stem (iPS) cells that exhibit many characteristics of embryonic stem (ES) cells. Herein, we show that the orphan nuclear receptor Esrrb works in conjunction with Oct4 and Sox2 to mediate reprogramming of mouse embryonic fibroblasts (MEFs) to iPS cells. Esrrb reprogrammed cells share similar expression and epigenetic signatures as ES cells. more...