Similar studies for GEO DataSets (Select 200016032) - GEO DataSets

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Items: 12

Select item 2000160321.

Gene expression data from severe asthmatic children: PBMC profiles during acute exacerbation versus convalescence

(Submitter supplied) Severe asthma exacerbations in children requiring hospitalisation are typically associated with viral infection, and occur almost exclusively amongst atopics, but the significance of these comorbidities is unknown. We hypothesised that underlying interactions between immunoinflammatory pathways related to responses to aeroallergen and virus are involved, and that evidence of these interactions is detectable in circulating cells during exacerbations. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3615
Platform:: GPL570
10 Samples

Download data: CEL

Series

Accession:: GSE16032

ID:: 200016032

Select item 36152.

Asthma exacerbation and convalescent phases: peripheral blood mononuclear cells

Analysis of peripheral blood mononuclear cells of children with acute asthma during exacerbation and at subsequent convalescence. Severe asthma exacerbations in children are associated with viral infection and occur among atopics. Results provide insight into the significance of these comorbidities.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 disease state sets

Platform:: GPL570
Series:: GSE16032
10 Samples

Download data: CEL

DataSet

Accession:: GDS3615

ID:: 3615

Select item 2000981523.

Expression data from two rat strains comparing naïve vs 24h picornavirus infection.

(Submitter supplied) Allergic (Th2high immunophenotype) asthmatics have a heightened susceptibility to common respiratory viral infections such as human rhinovirus. Evidence suggests that the innate interferon response is deficient in asthmatic/atopic individuals, whilst other studies show no differences in antiviral response pathways. Unsensitized and OVA-sensitized/challenged Th2high (BN rats) and Th2low immunophenotype (PVG rats) animals were inoculated intranasally with attenuated mengovirus (vMC0). more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL23368
12 Samples

Download data: CEL

Series

Accession:: GSE98152

ID:: 200098152

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000965304.

LPS binding protein and activation signatures are upregulated during asthma exacerbations in children

(Submitter supplied) Asthma exacerbations in children are associated with respiratory viral infection and atopy, resulting in systemic immune activation and infiltration of immune cells into the airways. The gene networks driving the immune activation and subsequent migration of immune cells into the airways remains incompletely understood. Cellular and molecular profiling of PBMC was employed on paired samples obtained from atopic asthmatic children (n = 19) during acute virus-associated exacerbations and later during convalescence. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
76 Samples

Download data: TXT

Series

Accession:: GSE96530

ID:: 200096530

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000119115.

Gene expression profiling of experimental asthma reveals a possible role of paraoxonase-1 in asthma

(Submitter supplied) Background: Several studies indicate that asthma is a polygenic disease, and its complexity originates from the interaction of an unknown number of genes with environmental factors. Objective: In this study we aimed to identify new genes, gene groups and pathways involved in the pathogenesis of experimental asthma. Methods: In an ovalbumin-induced murine model of asthma we applied microarray gene expression analysis of the lung at different time points in the asthmatic process. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL4134
12 Samples

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Series

Accession:: GSE11911

ID:: 200011911

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Select item 2001158246.

A network of transcriptome modules demonstrates mechanistic pathways of both virus induced and non-viral asthma exacerbations in children

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
1034 Samples

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Series

Accession:: GSE115824

ID:: 200115824

PubMed Full text in PMC Similar studies

Select item 2001158237.

A network of transcriptome modules demonstrates mechanistic pathways of both virus induced and non-viral asthma exacerbations in children [blood]

(Submitter supplied) We leverage a systems-scale network analysis approach to demonstrate repertoires of cellular transcriptional pathways underlying loss of asthma control, and show how these pathways differ in viral associated and non-viral exacerbations.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
511 Samples

Download data: TXT

Series

Accession:: GSE115823

ID:: 200115823

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001157708.

A network of transcriptome modules demonstrates mechanistic pathways of both virus induced and non-viral asthma exacerbations in children [nasal]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
523 Samples

Download data: TXT

Series

Accession:: GSE115770

ID:: 200115770

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000303269.

Virus-induced inflammatory gene networks underlying asthma exacerbations in vivo

(Submitter supplied) Global patterns of gene expression was profiled in nasal lavage samples obtained from asthmatic children during an acute Picornavirus-induced exacerbation and 7-14 days later. Gene coexpression network analysis and prior knowledge was employed to reconstruct the wiring diagram of the underlying gene networks.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4424
Platform:: GPL6244
32 Samples

Download data: CEL

Series

Accession:: GSE30326

ID:: 200030326

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 442410.

Acute Picornavirus-induced exacerbation in asthmatic children: nasal lavage cells

Analysis of paired nasal lavage samples obtained from asthmatic children during an acute Picornavirus-induced asthma exacerbation in vivo and 7-14 days later. Severe episodes can be life-threatening. Results provide insight into molecular mechanisms underlying virus-induced asthma exacerbations.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 16 individual, 2 protocol sets

Platform:: GPL6244
Series:: GSE30326
32 Samples

Download data: CEL

DataSet

Accession:: GDS4424

ID:: 4424

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20001930111.

Gene Expression Patterns in Peripheral Blood Mononuclear Cells Associated with Asthma Exacerbation Attack

(Submitter supplied) A large, prospective, non-interventional study was designed to study gene expression changes in peripheral blood mononuclear cells (PBMCs) associated with asthma exacerbations over the course of a year. PBMC samples were collected from subjects at the time of the study visits defined as 1) Quiet: during stable disease at 3 month intervals, 2) Exacerbation: during a 14 day period of deteriorating asthma and 3) Follow-up: within 14 days after cessation of an exacerbation. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
685 Samples

Download data: CEL

Series

Accession:: GSE19301

ID:: 200019301

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001490812.

Global expression profiling of CD4 T-cell responses to house dust mite allergens in human atopics and nonatopics.

(Submitter supplied) The aim of this study was to employ a systems-level analysis to elucidate gene expression networks operating in the CD4 T-cell responses which underpin human atopic disease. Keywords: Disease state analysis; T-cell response