GEO DataSets

(Submitter supplied) Wild-type (C57Bl6) mice were dark reared from birth to P42, then underwent monocular enucleation at P42. They were then placed in a normal light-dark environment for 4 days, after which they were sacrificed (at P46). Visual cortex was dissected from 1-mm thick coronal sections, and total RNA was extracted from the tissue lysate using Trizol (Gibco-BRL). Keywords: repeat

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

4 Samples

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(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

36 Samples

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(Submitter supplied) Wild-type (C57Bl6) mice underwent monocular enucleation at P100 and were sacrificed 4 days later at P104. Bilateral (non-deprived and deprived) visual cortex was dissected from 1-mm thick coronal sections, and total RNA was extracted from the tissue lysate using Trizol (Gibco-BRL). Keywords: repeat

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

6 Samples

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(Submitter supplied) Wild-type (C57Bl6) mice underwent monocular enucleation at P42 and were sacrificed 4 days later at P46. Bilateral (non-deprived and deprived) visual cortex was dissected from 1-mm thick coronal sections, and total RNA was extracted from the tissue lysate using Trizol (Gibco-BRL). Keywords: repeat

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

8 Samples

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(Submitter supplied) Wild-type (C57Bl6) mice underwent monocular enucleation at P20 and were sacrificed 4 days later at P24. Bilateral (non-deprived and deprived) visual cortex was dissected from 1-mm thick coronal sections, and total RNA was extracted from the tissue lysate using Trizol (Gibco-BRL). Keywords: repeat

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

8 Samples

Download data

(Submitter supplied) Wild-type (C57Bl6) mice underwent monocular enucleation at P14 and were sacrificed 4 days later at P18. Bilateral (non-deprived and deprived) visual cortex was dissected from 1-mm thick coronal sections, and total RNA was extracted from the tissue lysate using Trizol (Gibco-BRL). Keywords: repeat

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

10 Samples

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(Submitter supplied) Visual deprivation, either in the form of dark rearing (DR) or monocular deprivation (MD) are established paradigms for studying cortical plasticity. We have used miRNA microarray to uncover miRNAs whose expression is altered in primary visual cortex following DR and/or MD.

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL10384

9 Samples

Download data: TXT

(Submitter supplied) Two key paradigms for examining activity-dependent development of primary visual cortex (V1) involve either reduction of activity in both eyes via dark-rearing (DR) or imbalance of activity between the two eyes via monocular deprivation (MD). Combining DNA microarray analysis with computational approaches, RT-PCR, immunohistochemistry and physiological imaging, we find that DR leads to (i) upregulation of genes subserving synaptic transmission and electrical activity, consistent with a coordinated response of cortical neurons to reduction of visual drive, and (ii) downregulation of parvalbumin, implicating parvalbumin-expressing neurons as underlying the delay in cortical maturation after DR. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS1983 GDS1984 GDS1986

Platforms:

GPL83 GPL81 GPL82

36 Samples

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Analysis of primary visual cortex (V1) under conditions of binocular deprivation by dark-rearing (DR) or monocular deprivation (MD). Animals subjected to DR from birth till postnatal day (P) 27 or to MD from P11-12 to P27. Results provide insight into the role of visual activity in V1 development.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 other, 3 protocol sets

Platform:

GPL83

Series:

GSE4537

12 Samples

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Analysis of primary visual cortex (V1) under conditions of binocular deprivation by dark-rearing (DR) or monocular deprivation (MD). Animals subjected to DR from birth till postnatal day (P) 27 or to MD from P11-12 to P27. Results provide insight into the role of visual activity in V1 development.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 other, 3 protocol sets

Platform:

GPL82

Series:

GSE4537

12 Samples

Download data

Analysis of primary visual cortex (V1) under conditions of binocular deprivation by dark-rearing (DR) or monocular deprivation (MD). Animals subjected to DR from birth till postnatal day (P) 27 or to MD from P11-12 to P27. Results provide insight into the role of visual activity in V1 development.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 other, 3 protocol sets

Platform:

GPL81

Series:

GSE4537

12 Samples

Download data

(Submitter supplied) Analysis of gene expression before (P14), during (P28), and after (P60) the critical period for ocular dominance plasticity. Keywords: time course

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS3375 GDS3376 GDS3382

Platforms:

GPL83 GPL81 GPL82

30 Samples

Download data: CEL, CHP

Analysis of visual cortices before the critical period for ocular dominance plasticity opens [postnatal day 14 (P14)], at the peak sensitivity of the critical period (P28), and after the critical period (P60). Results provide insight into the molecular mechanisms associated with the critical period.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age sets

Platform:

GPL83

Series:

GSE11764

10 Samples

Download data: CEL, CHP

Analysis of visual cortices before the critical period for ocular dominance plasticity opens [postnatal day 14 (P14)], at the peak sensitivity of the critical period (P28), and after the critical period (P60). Results provide insight into the molecular mechanisms associated with the critical period.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age sets

Platform:

GPL82

Series:

GSE11764

10 Samples

Download data: CEL, CHP

Analysis of visual cortices before the critical period for ocular dominance plasticity opens [postnatal day 14 (P14)], at the peak sensitivity of the critical period (P28), and after the critical period (P60). Results provide insight into the molecular mechanisms associated with the critical period.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age sets

Platform:

GPL81

Series:

GSE11764

10 Samples

Download data: CEL, CHP

(Submitter supplied) We analyzed whether cochlear removal-induced transcriptional changes in the cochlear nucleus (CN) were due to loss of electrical activity in the 8th nerve. Pharmacological activity blockade of the auditory nerve for 24 h resulted in similar expression changes for only a subset of genes. Thus, an additional factor not dependent on action potential-mediated signaling must also regulate transcriptional responses to deafferentation in the CN. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8321

6 Samples

Download data: CEL

(Submitter supplied) Deprivation of peripheral nerve input by cochlear removal in young mice results in dramatic neuron death in the cochlear nucleus (CN). The same manipulation in older mice does not result in significant loss. The molecular basis of this critical period of vulnerability remains largely unknown. Here we identified genes regulated at early time points after cochlear removal at ages when neurons are vulnerable (postnatal day (P)7) or invulnerable (P21) to this challenge. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

44 Samples

Download data: CEL

(Submitter supplied) The role of postnatal experience in sculpting cortical circuitry, while long appreciated, is poorly understood at the level of cell types. We explore this in the mouse primary visual cortex (V1) using single-nucleus RNA-sequencing, visual deprivation, genetics, and functional imaging. We find that vision selectively drives the specification of glutamatergic cell types in upper layers (L) (L2/3/4), while deeper-layer glutamatergic, GABAergic, and non-neuronal cell types are established prior to eye opening. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

35 Samples

Download data: CSV