GEO DataSets

Analysis of bronchial epithelial cells treated with interferon (IFN) gamma, or dexamethasone (dex), or both. IFN-gamma plays a role in lung inflammatory responses and corticosteroids such as dex are used as treatments for inflammation. Cells examined 8 or 24 hours after treatment.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 agent, 2 time sets

Platform:

GPL8300

Series:

GSE1815

36 Samples

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(Submitter supplied) RNA from cultured human bronchial epithelial cells treated for 8 hours or for 24 hours with medium alone, interferon gamma, dexamethasone or both interferon gamma and dexamethasone. Keywords = interferon gamma Keywords = dexamethasone Keywords = human bronchial epithelial cells Keywords: dose response

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1256

Platform:

GPL8300

36 Samples

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(Submitter supplied) Prolonged use of glucocorticoids can lead to the formation of a cataract, however the mechanism is not known. We recently reported the presence of the functional glucocorticoid receptor in immortalized cultured mammalian lens epithelial cells (Gupta & Wagner, Invest Ophthalmol Vis Sci 2003), but the short term biological effect of glucocorticoid action in lens epithelial cells is not known. This study seeks to examine glucocorticoid induced changes in global gene expression in LECs. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1353

Platform:

GPL96

12 Samples

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Analysis of cultured immortalized lens epithelial cells (LEC) 4 and 16 hours after treatment with 1 uM dexamethasone, a glucocorticoid steroid hormone. Long-term glucocorticoid use can induce cataract formation. Results identify glucocorticoid targets and short-term effects of glucocorticoid on LECs

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 2 time sets

Platform:

GPL96

Series:

GSE3040

12 Samples

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(Submitter supplied) PURPOSE. Triamcinolone acetonide (TA) and dexamethasone (DEX) are corticosteroids commonly used for ocular inflammation but both can cause ocular hypertension. We investigated the differential gene expression profile of human trabecular meshwork (TM) cells in response to treatment by TA compared to that by DEX. METHODS. Total RNA was extracted from cultured human TM cells treated with TA or DEX and used for microarray gene expression analysis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4564

9 Samples

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(Submitter supplied) Microglial cells are resident macrophages in the central nervous system (CNS) and play a pivotal role in the innate and adaptive immune responses against microbial infections. The immune functions of microglia are regulated by a milieu of cytokines including interferon (IFN)-gamma. We here performed a series of experiments to acertain the transcriptional profile of human fetal microglial cells at 1, 6, and 24 h after IFN-gamma treatment. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1036

Platform:

GPL96

24 Samples

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Expression profiling of microglial cells obtained from 4 different samples following treatment with 200 u/ml interferon-gamma (IFN-gamma). Cells examined 1, 6, and 4 hours after treatment. Results provide insight into the regulation of immune functions in microglia by IFN-gamma.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 4 specimen, 3 time sets

Platform:

GPL96

Series:

GSE1432

24 Samples

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(Submitter supplied) Cultured epidermal keratinocyte controls used for IFNg, TNFa and IL1 treatment. Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1846

Platform:

GPL8300

9 Samples

Download data: CEL, EXP

Analysis of keratinocytes treated with interferon gamma (IFN-gamma) for up to 48 hours. IFN-gamma is a multifunctional, immunomodulatory cytokine with cell type-specific antiviral activities. Results provide insight into molecular processes regulated by IFN-gamma in keratinocytes.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 4 time sets

Platform:

GPL8300

Series:

GSE440

9 Samples

Download data: CEL, EXP

(Submitter supplied) PGE2 is a major mediator of inflammation and is present at high concentrations in the synovial fluid of rheumatoid arthritis (RA) patients. PGE2, acting through the EP4 receptor, has both pro- and anti-inflammatory roles in vivo. To shed light on this dual role of PGE2, we investigated its effects in whole blood and in primary human fibroblast-like synoviocytes. Gene expression analysis in human leukocytes, confirmed at the protein level, revealed an EP4-dependent inhibition of the expression of genes involved in the IFN-gamma activation pathway, including IFN-gamma itself. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4372

12 Samples

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(Submitter supplied) The mechanical effect of raised intraocular pressure is a recognised stimulus for optic neuropathy in primary open angle glaucoma (POAG). Characteristic extra-cellular matrix (ECM) remodelling accompanies axonal damage in the lamina cribrosa (LC) of the optic nerve head in POAG. Glial cells in the lamina cribrosa may play a role in this process but the precise cellular responses to mechanical forces in this region are unknown. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

2 Samples

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(Submitter supplied) Genes regulated by inflammatory cytokines in five primary endothelial cell types Keywords: ordered

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS498 GDS499 GDS501 GDS502

Platform:

GPL371

15 Samples

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Examination of gene expression induced by interferon gamma (IFNg), tumor necrosis factor alpha (TNFa) and interleukin 4 (IL4) inflammatory cytokines on primary colon endothelial cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent sets

Platform:

GPL371

Series:

GSE569

3 Samples

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Examination of gene expression induced by interferon gamma (IFNg), tumor necrosis factor alpha (TNFa) and interleukin 4 (IL4) inflammatory cytokines on primary dermal endothelial cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent sets

Platform:

GPL371

Series:

GSE569

3 Samples

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Examination of gene expression induced by interferon gamma (IFNg), tumor necrosis factor alpha (TNFa) and interleukin 4 (IL4) inflammatory cytokines on primary aortic endothelial cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent sets

Platform:

GPL371

Series:

GSE569

3 Samples

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Examination of gene expression induced by interferon gamma (IFNg), tumor necrosis factor alpha (TNFa) and interleukin 4 (IL4) inflammatory cytokines on primary lung endothelial cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent sets

Platform:

GPL371

Series:

GSE569

3 Samples

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(Submitter supplied) Background: Glucocorticoids (GCs) are widely used anti-inflammatory drugs. While useful in clinical practice, patients taking GCs often suffer from skeletal side effects including growth retardation and decreased bone quality in adults. On a physiological level, GCs have been implicated in the regulation of chondrogenesis and osteoblast differentiation, as well as maintaining homeostasis in cartilage and bone. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2802

Platform:

GPL1261

12 Samples

Download data: CEL, CHP, EXP

Analysis of primary cultured fetal chondrocytes treated with pharmacological doses of dexamethasone (DEX) for 6 and 24 hours. DEX is a synthetic glucorticoid (GC) receptor agonist. Results provide insight into the effects of pharmacological GC on chondrocytes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 time sets

Platform:

GPL1261

Series:

GSE7683

12 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) Reference pool RNA versus RNA from dexamethasone treated gut cells. Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1465

4 Samples

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(Submitter supplied) Clinical variability in sickle cell disease (SCD) suggests a role for extra-erythrocytic factors in the pathogenesis of vasoocclusion. We hypothesized that one potential factor, endothelial dysfunction, results from induction of phenotypic changes by circulating factors in SCD patients. The database reports gene expression in cultured human pulmonary artery endothelial cells (HPAEC) exposed to plasma from: a) sickle acute chest syndrome (ACS) patients (samples ; b) SCD patients at steady-state and c) normal volunteers using microarrays (U133A-B GeneChip Affymetrix). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS1257 GDS1258

Platforms:

GPL96 GPL97

65 Samples

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