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Series GSE1849 Query DataSets for GSE1849
Status Public on Apr 04, 2005
Title Differential Gene Expression in Pulmonary Artery Endothelial Cells Exposed to Sickle Cell Plasma
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Clinical variability in sickle cell disease (SCD) suggests a role for extra-erythrocytic factors in the pathogenesis of vasoocclusion. We hypothesized that one potential factor, endothelial dysfunction, results from induction of phenotypic changes by circulating factors in SCD patients. The database reports gene expression in cultured human pulmonary artery endothelial cells (HPAEC) exposed to plasma from: a) sickle acute chest syndrome (ACS) patients (samples ; b) SCD patients at steady-state and c) normal volunteers using microarrays (U133A-B GeneChip Affymetrix).
Keywords: other
Contributor(s) Klings ES, Safaya S, Adewoe AH, Odhiambo A, Frampton G, Lenburg M, Sebastiani P, Steinberg MH, Farber HW
Citation(s) 15741505
Submission date Oct 19, 2004
Last update date Aug 10, 2018
Contact name Paola Sebastiani
Phone 617 538 5877
Organization name Boston University
Street address
City Boston
State/province MA
ZIP/Postal code 02118
Country USA
Platforms (2)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
GPL97 [HG-U133B] Affymetrix Human Genome U133B Array
Samples (65)
GSM32620 Cells Incubated with Normal Patient Plasma
GSM32621 2a-r1
GSM32622 2a_r2
BioProject PRJNA90467

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