GEO DataSets

Analysis of testes from animals treated with JQ1, a small-molecule inhibitor of the testis-specific bromodomain-containing protein BRDT. BRDT is essential for spermatogenesis. Results provide insight into the molecular consequences of BRDT inhibition by JQ1.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL6887

Series:

GSE37894

6 Samples

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Analysis of livers of C57BL/6J mice fed a high fat diet for up to 24 weeks. Significant body weight gain was observed after 4 weeks. Results provide insight into the effect of high fat diets on metabolism in the liver.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 protocol, 9 time sets

Platform:

GPL6887

Series:

GSE39549

51 Samples

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Analysis of epididymal and mesenteric white adipose tissues (WAT) of mice fed a high fat diet for up to 24 weeks. Excessive fat accumulation was evident in visceral WAT depots after 4 weeks. Results provide insight into the molecular events that occur during the development of diet-induced obesity.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 protocol, 5 time, 2 tissue sets

Platform:

GPL6887

Series:

GSE39549

40 Samples

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Analysis of interscapular brown adipose tissues from mice fed a high fat diet for up to 24 weeks. Results compared to those from epididymal white adipose tissues (GDS6247) in order to provide insight into the effect of high-fat diets on the development of brown and white adipose tissues.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 protocol, 6 time sets

Platform:

GPL6887

Series:

GSE64718

33 Samples

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Analysis of pancreatic ductal adenocarcinoma (PDAC) tumors from PKT; αSMA-tk+ transgenics injected daily with ganciclovir at 6 weeks of age for 10 days or less to deplete αSMA+ myofibroblasts and treated with anti-CTLA4. Results provide insight into molecular basis of anti-CTLA4 therapy in PDAC.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 protocol sets

Platform:

GPL6887

Series:

GSE52812

9 Samples

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Analysis of pancreatic ductal adenocarcinoma (PDAC) tumors from PKT; αSMA-tk+ transgenics injected daily with ganciclovir at 6 weeks of age for 10 days or less to selectively deplete αSMA+ myofibroblasts. Results provide insight into the role of αSMA+ myofibroblasts in late-stage PDAC.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL6887

Series:

GSE52812

6 Samples

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Analysis of pancreatic ductal adenocarcinoma (PDAC) tumors from PKT; αSMA-tk+ transgenics injected daily with ganciclovir at 4 to 4.5 weeks of age for 14 days or less to selectively deplete αSMA+ myofibroblasts. Results provide insight into the role of αSMA+ myofibroblasts in early-stage PDAC.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL6887

Series:

GSE52812

6 Samples

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Analysis of ESC line E14 expressing 4-hydroxytamoxifen (4-OHT)-inducible Snai1-ER at various time points of induction with 4-OHT. Snai1 (Snail homolog 1) is a member of the Snail family of zinc finger transcription factors. Results provide insight into the role of Snai1 in ESC differentiation.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 6 time sets

Platform:

GPL6887

Series:

GSE57854

6 Samples

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Analysis of arteries from C57BL/6 males pretreated with DNMT inhibitor 5Aza for 2 wk, then subjected to partial carotid ligation (PCL) and continued 5Aza treatment for 1 wk after ligation. PCL induces disturbed blood flow. Results provide insight into molecular basis of atherosclerosis development.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 protocol, 2 tissue sets

Platform:

GPL6887

Series:

GSE56143

12 Samples

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Analysis of lung tumors isolated from mice that develop KRAS-driven lung tumors. The KrasG12D mice were fed a high-calorie diet (HCD) starting 12 wk before tumor induction; tumors were collected 11 wk after tumor induction. Results provide insight into HCD effects on KRAS-driven lung tumorigenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 growth protocol sets

Platform:

GPL6887

Series:

GSE56260

11 Samples

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Analysis of adipose progenitor cells from animals fed a diet supplemented with rosiglitazone (ROS) for 2 months. ROS is a thiazolidinedione antidiabetic drug. Results provide insight into the effect of chronic ROS administration on the stem cell properties of adipose progenitor cells.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL6887

Series:

GSE30116

6 Samples

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Analysis of lung from M. tuberculosis (MT)-infected C57BL/6 mice treated with metformin (MET). The antidiabetic drug MET is an activating agent of adenosine monophosphate-activated protein kinase (AMPK). Results provide insight into the potential use of MET as adjunct antituberculosis therapy.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 infection sets

Platform:

GPL6887

Series:

GSE57275

14 Samples

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Analysis of liver from diet-induced obese males depleted for monoacylglycerol acyltransferase 1 (Mogat1) via intraperitoneal injections of antisense oligonucleotide directed against Mogat1. Results provide insight into the role of Mogat1 in the development of nonalcoholic steatohepatitis (NASH).

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL6887

Series:

GSE60349

8 Samples

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Analysis of leukemia stem cells (LSC) knocked down for casein kinase 1 α (Csnk1a1). Csnk1a1, a serine-threonine kinase, is critical for acute myeloid leukemia (AML) cell survival in vivo. Results provide insight into the role of Csnk1a1 in AML.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 protocol sets

Platform:

GPL6887

Series:

GSE52928

9 Samples

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Analysis of liver of C57BL/6J male offspring exposed prenatally to a western-style diet (rich in energy, fat, cholesterol) or a low-fat diet and then a post-weaning low-fat diet. Results provide insight into the role of maternal western diet in the development of liver disease in offspring.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL6887

Series:

GSE44901

11 Samples

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Analysis of anterior and posterior stomach regions following vagotomy of anterior stomach of 6 month old INS-GAS animals at 2, 4, and 6 months post-surgery. Results provide insight into molecular mechanisms underlying denervation-mediated suppression of gastric tumorigenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 time, 2 tissue sets

Platform:

GPL6887

Series:

GSE30295

32 Samples

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Analysis of embryonic stem cells from mutants lacking TRPM7. TRPM7 is a kinase and an ion channel. Results provide insight into the function of TRPM7 in cell differentiation and embryonic development.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL6887

Series:

GSE55578

6 Samples

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Analysis of fatty acid (FA)-loaded macrophages stimulated with bacterial lipopolysaccharide (LPS). LPS is a Toll-like receptor 4 (TLR4) agonist. Results provide insight into the molecular mechanisms that promote triglyceride retention in LPS-exposed macrophages.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 4 other, 4 protocol sets

Platform:

GPL6887

Series:

GSE42190

15 Samples

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Analysis of quadriceps muscles of mutants lacking kelch-like family member 40 (KLHL40). KLHL40 mutations occur in severe nemaline myopathies (NMs). NMs are congenital myopathies that can result in lethal muscle dysfunction. Results provide insight into the role of KLHL40 in the pathogenesis of NM.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL6887

Series:

GSE56570

6 Samples

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Analysis of liver of C57BL/6J male offspring exposed prenatally to a western-style diet (rich in energy, fat, cholesterol) or a low-fat diet and then a post-weaning western diet. Results provide insight into the role of maternal western diet in the development of liver disease in offspring.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL6887

Series:

GSE44901

11 Samples

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