Casein kinase 1 α deficiency effect on leukemia stem cells
Summary:
Analysis of leukemia stem cells (LSC) knocked down for casein kinase 1 α (Csnk1a1). Csnk1a1, a serine-threonine kinase, is critical for acute myeloid leukemia (AML) cell survival in vivo. Results provide insight into the role of Csnk1a1 in AML.
Järås M, Miller PG, Chu LP, Puram RV et al. Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia. J Exp Med 2014 Apr 7;211(4):605-12. PMID: 24616378