ventricular function - GEO DataSets

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Select item 2002659311.

Thymic stromal lymphopoietin modulates T cell response to improve cardiac repair post-myocardial infarction

(Submitter supplied) The inflammatory response is associated with cardiac repair and ventricular remodeling after myocardial infarction (MI). The key inflammation regulatory factor thymic stromal lymphopoietin (TSLP) plays a critical role in various diseases. However, its role in cardiac repair after MI remains uncertain. In this study, we elucidated the biological function and mechanism of action of TSLP in cardiac repair and ventricular remodeling following MI. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: TXT

Series

Accession:: GSE265931

ID:: 200265931

Select item 2002717932.

Regression of Post-Prandial Cardiac Hypertrophy in Burmese Pythons is Mediated by FoxO1

(Submitter supplied) As ambush-hunting predators that consume large prey after long intervals of fasting, Burmese pythons evolved with unique adaptations for regulating organ structure and function. Among these is cardiac hypertrophy that develops within three days following a meal (1, 2), which we previously showed was initiated by circulating growth factors (3). Post-prandial cardiac hypertrophy in pythons also rapidly regresses with subsequent fasting (2); however, the molecular mechanisms that regulate the dynamic cardiac remodeling in pythons during digestion are largely unknown. more...

Organism:: Python bivittatus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL34688
8 Samples

Download data: TXT

Series

Accession:: GSE271793

ID:: 200271793

Select item 2002711773.

Gene expression profile at single-cell level of cardiac cells derived from adult heart following injury

(Submitter supplied) Myocardial injury may ultimately lead to adverse ventricular remodeling and development of heart failure (HF), which is a major cause of morbidity and mortality worldwide. Given the slow pace and substantial costs of developing new therapeutics, drug repurposing is an attractive alternative. Studies of many organs, including the heart, highlight the importance of the immune system in modulating injury and repair outcomes. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: ZIP

Series

Accession:: GSE271177

ID:: 200271177

PubMed Similar studies

Select item 2002403104.

Direct in vivo cardiac reprogramming improves cardiac function and ventricular remodeling in chronic MI.

(Submitter supplied) Heart failure (HF) is a leading cause of morbidity and mortality. As adult cardiomyocytes (CMs) have little regenerative capacity, after myocardial infarction (MI), resident cardiac fibroblasts (CFs) synthesize extracellular matrix to form scar tissues, resulting in myocardial remodeling and HF. Thus, both cardiac regeneration and fibrosis are therapeutic targets for chronic MI. We previously reported that fibroblasts were directly reprogrammed into induced CMs (iCMs) by overexpression of cardiogenic transcription factors in acute and chronic MI. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL23038
6 Samples

Download data: CEL

Series

Accession:: GSE240310

ID:: 200240310

Select item 2002101805.

Effect of neonatal right ventricular pressure overload on gene expression and regions of open chromatin during postnatal heart development

(Submitter supplied) To investigate the effect of pressure overload (PO) during postnatal right ventricular (RV) development, we established the RV PO model by conducting pulmonary artery banding (PAB) surgery on neonatal Sprague-Dawley (SD) rats. We then performed gene expression and chromatin openness profiling analysis using data obtained from RNA-seq and ATAC-seq of RV free walls from PO and sham-operated rats at postnatal day 21 (P21).

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL25947
12 Samples

Download data: TXT

Series

Accession:: GSE210180

ID:: 200210180

PubMed Full text in PMC Similar studies

Select item 2001869966.

Comprehensive transcriptome analysis of lung tissues in the sugen/hypoxia rats with/without treatment of chrysin or trimetazidine

(Submitter supplied) Pulmonary arterial hypertension (PAH) is a debilitating progressive disease characterized by high blood pressure in the pulmonary artery. Chrysin (5,7-dihydroxyflavone) is a phytochemical, which is a flavonoid widely present in plant sources. It is known that right ventricular dysfunction is the worst mortality predictor in patient with PAH. Recent studies have shown that chrysin improves hemodynamic parameters including right ventricular pressure, right ventricular hypertrophy, and pulmonary vascular remodeling in a rat model of chronic hypoxia-induced pulmonary hypertension. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20084
16 Samples

Download data: XLSX

Series

Accession:: GSE186996

ID:: 200186996

SRA Run Selector

Select item 2002496977.

Transcriptional changes of the extracellular matrix in chronic thromboembolic pulmonary hypertension governs right ventricle remodeling and recovery

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL18573 GPL30173
110 Samples

Download data

Series

Accession:: GSE249697

ID:: 200249697

Select item 2002496968.

Transcriptional changes of the extracellular matrix in chronic thromboembolic pulmonary hypertension governs right ventricle remodeling and recovery [ext395_rnaseq]

(Submitter supplied) The present prospective study included a total number of 71 patients with a final diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH), who were treated by pulmonary endarterectomy (PEA) at the Kerckhoff Heart and Thorax Center between 2016 and 2020. Biopsies of the free right ventricular wall from 71 patients were collected at baseline (BL) during PEA. In a subgroup of 24 patients, myocardial interventricular septum biopsie were obtained during right heart catheterization (RHC) 12 months after PEA (postPEA) In this case, to account for technical and safety aspects, the specimens were taken from the myocardial interventricular septum. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30173
95 Samples

Download data: TXT

Series

Accession:: GSE249696

ID:: 200249696

Analyze with GEO2R

Select item 2002496949.

Transcriptional changes of the extracellular matrix in chronic thromboembolic pulmonary hypertension governs right ventricle remodeling and recovery [ext327_rnaseq]

(Submitter supplied) The present prospective study included a total number of 3 patients with a final diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH), who were treated by pulmonary endarterectomy (PEA) at the Kerckhoff Heart and Thorax Center between 2016 and 2020. Biopsies of the myocardial interventricular septum from 3 patients were collected at baseline (BL) before PEA surgery (pre-septal-PEA) In this case, to account for technical and safety aspects, the specimens were taken from the myocardial interventricular septum. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30173
6 Samples

Download data: TXT

Series

Accession:: GSE249694

ID:: 200249694

Analyze with GEO2R

Select item 20024969110.

Transcriptional changes of the extracellular matrix in chronic thromboembolic pulmonary hypertension governs right ventricle remodeling and recovery [ext128_rnaseq]

(Submitter supplied) The present prospective study included a total number of 9 patients with a final diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH), who were treated by pulmonary endarterectomy (PEA) at the Kerckhoff Heart and Thorax Center between 2016 and 2020. Biopsies of theright ventricularfreewall from9patients were collected at baseline (BL) before PEA surgery (prePEA). Patients were grouped in severe and moderate risk groups according to 1 year mortality risk by applying a modified version of the European Society of Cardiology (ESC) guidelines risk stratification model according to their BL characteristics. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
9 Samples

Download data: TXT

Series

Accession:: GSE249691

ID:: 200249691

Analyze with GEO2R

Select item 20026049211.

Diminished arachidonate 5-lipoxygenase perturbs phase separation and transcriptional response of Runx2 to reverse pathological ventricular remodeling

(Submitter supplied) Untargeted metabolomics showed that serum 5-HETE (a primary product of Alox5) levels were little changed in patients with cardiac hypertrophy, while Alox5 expression was significantly upregulated in murine hypertensive cardiac samples and human cardiac samples of hypertrophy, which prompted us to test whether high Alox5 levels under hypertensive stimuli were directly associated with pathologic myocardium in an enzymatic activity-independent manner. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
12 Samples

Download data: TXT

Series

Accession:: GSE260492

ID:: 200260492

Select item 20025378212.

Whole blood transcriptomics reveals G-CSF as a mediator of cardiopulmonary bypass- induced systemic inflammatory response syndrome

(Submitter supplied) Objectives: Systemic inflammatory response syndrome (SIRS) is a frequent complication of cardiopulmonary bypass (CPB). SIRS is associated with significant morbidity and mortality, but its pathogenesis remains incompletely understood, and as a result biomarkers are lacking, and treatment remains expectant and supportive. This study aimed to understand the pathophysiological mechanisms driving SIRS induced by CPB and identify novel therapeutic targets that might reduce systemic inflammation and improve patient outcomes. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
77 Samples

Download data: CSV

Series

Accession:: GSE253782

ID:: 200253782

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20025420713.

Cyclosporin ameliorates right ventricular remodeling of postnatal mice with volume overload.

(Submitter supplied) We reported the RNAseq analyses of right ventricular free wall of myocardium in three groups of mice（3 in each group）at postnatal day 14 (P14). The mice in volume overload (VO) group underwent an abdominal surgery by puncture from aorta to inferior vena cava at P7, mice in Sham group underwent the same surgery except for the puncture. The mice in CsA group were VO mice who were also injected with cyclosporin A(CsA) for seven days. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
9 Samples

Download data: TXT

Series

Accession:: GSE254207

ID:: 200254207

Select item 20023159714.

Irisin deficiency exacerbates diet-induced insulin resistance and cardiac dysfunction and promotes ischemia and reperfusion injury

(Submitter supplied) The myokine irisin is involved in the regulation of a variety of physiological conditions, metabolism, and survival. We and others have demonstrated that recombinant irisin contributes critically to modulation of insulin resistance and cardiac function. However, the molecular mechanisms by which irisin exerts its physiological effects on cardiac function and insulin sensitivity remain unclear. We utilized the CRISPR/Cas9 genome editing system to delete irisin. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL17791
6 Samples

Download data: CEL

Series

Accession:: GSE231597

ID:: 200231597

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20024595415.

Retinoic acid modulation guides human-induced pluripotent stem cell differentiation towards left or right ventricle-like cardiomyocytes

(Submitter supplied) Background: Cardiomyocytes (CMs) induced from human induced pluripotent stem cells (hiPSCs) by traditional methods are a mix of atrial and ventricular CMs and many other non-cardiomyocytes. Retinoic acid (RA) plays an important role in regulation of the spatiotemporal development of the embryonic heart and high concentrations of RA have been shown to steer differentiation towards atrial CMs, whereas lower concentrations of RA promote a more ventricular-like CM profile. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
9 Samples

Download data: TXT

Series

Accession:: GSE245954

ID:: 200245954

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20018530016.

Expression data from adult left ventricular heart tissue of hypereosinophilic mice and controls

(Submitter supplied) Hypereosinophilic syndrome is a progressive disease with extensive eosinophilia that results in organ damage. Patients suffer from frequent cardiac pathologies and a high mortality rate. A better understanding of the mechanisms of eosinophil-mediated tissue damage would benefit the development of new therapies. Here, we describe the cardiac pathologies that develop in a mouse model of hypereosinophilic syndrome. more...