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| Status |
Public on May 16, 2024 |
| Title |
Comprehensive transcriptome analysis of lung tissues in the sugen/hypoxia rats with/without treatment of chrysin or trimetazidine |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Pulmonary arterial hypertension (PAH) is a debilitating progressive disease characterized by high blood pressure in the pulmonary artery. Chrysin (5,7-dihydroxyflavone) is a phytochemical, which is a flavonoid widely present in plant sources. It is known that right ventricular dysfunction is the worst mortality predictor in patient with PAH. Recent studies have shown that chrysin improves hemodynamic parameters including right ventricular pressure, right ventricular hypertrophy, and pulmonary vascular remodeling in a rat model of chronic hypoxia-induced pulmonary hypertension. On the other hand, trimetazidine (TMZ) is an anti-ischemic agent widely used in the treatment of coronary artery disease. It has been reported that trimetazidine therapy for 3 months on top of standard PAH regime significantly improve right ventricular ejection fraction and functional capacity in patient with PAH. However, the effects of chrysin or trimetazidine on gene expression in lung of patient with PAH. Here, we performed that a comprehensive analysis of gene expression changes in lung tissues of sugen-received rats under hypoxic conditions, which is a model of PAH with chrysin or trimetazidine treatment using RNA sequencing (RNA-seq).
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| Overall design |
mRNA profiles of lung tissues were generated by RNA sequencing using the NextSeq 500 (Illumina).
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| Contributor(s) |
Kim J, Yanagisawa A, Kobayashi T, Kasuya Y, Tatsumi K |
| Citation missing |
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| |
| Submission date |
Nov 02, 2021 |
| Last update date |
May 16, 2024 |
| Contact name |
Jun-Dal Kim |
| Organization name |
University of Toyama
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| Department |
Department of Complex Biosystem Research (CBR), Institute of National Medicine (INM)
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| Lab |
Complex Biosystem Research Lab.
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| Street address |
2630 Sugitani
|
| City |
Toyama |
| State/province |
Toyama |
| ZIP/Postal code |
930-0194 |
| Country |
Japan |
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| Platforms (1) |
| GPL20084 |
Illumina NextSeq 500 (Rattus norvegicus) |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA777239 |
| SRA |
SRP344220 |
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