torula appressifolia - GEO DataSets

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Select item 2002778491.

Pathogen Class-specific Transcriptional Responses Derived from PBMCs Accurately Discriminate Between Fungal, Bacterial, and Viral Infections [ValidationCohort]

(Submitter supplied) Host gene expression responses can be used to determine the etiology of acute infection. PBMCs were stimulated with bacterial, viral, and fungal stimuli and then analyzed for differential gene expression utilizing microarrays to derive pathogen class-specific gene expression classifiers of infection. Validation Cohort: peripheral blood samples of human patients with acute viral, bacterial, or fungal infections

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL571
61 Samples

Download data: CEL

Series

Accession:: GSE277849

ID:: 200277849

Analyze with GEO2R

Select item 2002778482.

Pathogen Class-specific Transcriptional Responses Derived from PBMCs Accurately Discriminate Between Fungal, Bacterial, and Viral Infections [DiscoveryCohort]

(Submitter supplied) Host gene expression responses can be used to determine the etiology of acute infection. PBMCs were stimulated with bacterial, viral, and fungal stimuli and then analyzed for differential gene expression utilizing microarrays to derive pathogen class-specific gene expression classifiers of infection. Discovery Cohort: In vitro human PBMC challenges were performed with bacteria (gram postive and gram negative), viruses (4 strains of influenza), and fungi (Cryptococcus and Candida)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL571
54 Samples

Download data: CEL

Series

Accession:: GSE277848

ID:: 200277848

Analyze with GEO2R

Select item 2002638063.

Overcoming amphotericin B resistance in Candida auris using the antiemetic drug, rolapitant

(Submitter supplied) The emergence of Candida auris poses a significant health challenge that has led to a new era of multidrug-resistant fungal infections. Invasive infections caused by C. auris are usually associated with remarkable morbidity and mortality. For many years, amphotericin B (AmB) remained the most efficient and the last line of treatment against most hard-to-treat fungal infections. However, strains of C. more...

Organism:: Candidozyma auris

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28368
3 Samples

Download data: XLSX

Series

Accession:: GSE263806

ID:: 200263806

Select item 2002714854.

Innate cells and STAT1-dependent signals orchestrate vaccine-induced protection against invasive Cryptococcus infection

(Submitter supplied) Fungal pathogens are underappreciated causes of significant morbidity and mortality worldwide. In previous studies we determined that a heat-killed, Cryptococcus neoformans fbp1-deficient strain (HK-fbp1) is a potent vaccine candidate. We determined that vaccination with HK-fbp1 confers protective immunity against lethal Cryptococcosis in an interferon γ (IFNγ)-dependent manner. In this study, we set out to uncover cellular sources and relevant targets of the protective effects of IFNγ in response to the HK-fbp1 vaccine. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
10 Samples

Download data: SF

Series

Accession:: GSE271485

ID:: 200271485

Select item 2002609325.

QTL Mapping and Bulk Segregant Analysis identifies CO2 tolerance genes associated with virulence in the global pathogen Cryptococcus neoformans

(Submitter supplied) Cryptococcus neoformans is a ubiquitous free-living soil yeast and opportunistic pathogen that causes ~223,100 cases of cryptococcal meningitis per year, killing over 180,000 people. The pathogenicity of C. neoformans relies on its adaptation to the host conditions. An important difference between its natural environment and the mammalian host is the concentration of CO2. CO2 levels in the host fluctuate around 5%, which is ~125-fold higher than in ambient air. more...

Organism:: Cryptococcus neoformans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21073
18 Samples

Download data: XLSX

Series

Accession:: GSE260932

ID:: 200260932

PubMed Full text in PMC Similar studies

Select item 2002695126.

Effect of Calorie Restriction in the Congenic Mating Types of Cryptococcus neoformans

(Submitter supplied) Cryptococcus neoformans (Cn) is an opportunistic fungal microorganism that causes life-threatening meningoencephalitis. Calorie restriction is an intervention that extends the lifespan of Cn. The mating types of Cn have striking differences in prevalence in both environmental and clinical settings. This is hypothesized to be due to differences in stress responses between mating types. Using RNAseq, we investigated how the two mating types respond to the stress of starvation during calorie restriction.

Organism:: Cryptococcus neoformans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28713
8 Samples

Download data: TXT

Series

Accession:: GSE269512

ID:: 200269512

PubMed Full text in PMC Similar studies

Select item 2002225647.

Characterizing the transcriptional role of L-DOPA and antimycin A on mitichondrial regulation in Cryptococcus neoformans using a cir1 knockout strain

(Submitter supplied) Proper mitochondrial function is critical for the ability of the fungal pathogen Cryptococcus neoformans to cause disease. Mitochondrial dysfunction of WT cells treated with antimycin A or L-DOPA, or on cells lacking Cir1 is evident from this dataset. These experiments revealed influences on transcript levels of genes encoding Fe-S cluster assembly components and the response to oxidative stress in Cryptococcus neoformans.

Organism:: Cryptococcus neoformans var. grubii H99

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24579
15 Samples

Download data: TXT

Series

Accession:: GSE222564

ID:: 200222564

PubMed Full text in PMC Similar studies

Select item 2002551608.

Arginase inhibitor reduces fungal dissemination in murine pulmonary cryptococcosis by promoting anti-cryptococcal immunity

(Submitter supplied) Elevation of arginase enzyme activity in the lung contributes to the pathogenesis of various chronic inflammatory diseases and infections. Inhibition of arginase expression and activity is able to alleviate those effects. Here, we investigated the immunomodulatory effect of arginase inhibitor in C. neoformans infection. In the pulmonary cryptococcosis model that was shown to recapitulate human infection, we found arginase expression was excessively induced in the lung during the late stage of infection. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
9 Samples

Download data: TXT

Series

Accession:: GSE255160

ID:: 200255160

PubMed Similar studies

Select item 2002440949.

Lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug-resistant Candida auris

(Submitter supplied) Candida auris has emerged as a problematic fungal pathogen associated with high morbidity and mortality. Amphotericin B (AmB) is the most effective antifungal used to treat invasive fungal candidiasis, with resistance rarely observed among clinical isolates. However, C. auris possesses extraordinary resistant profiles against all available antifungal drugs, including AmB. In our pursuit of potential solutions, we conducted a screening of a panel of 727 FDA-approved drugs and identified the proton pump inhibitor lansoprazole (LNP) as a potent enhancer of AmB’s activity against C. more...

Organism:: Candidozyma auris

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28368
12 Samples

Download data: XLSX

Series

Accession:: GSE244094

ID:: 200244094

PubMed Full text in PMC Similar studies

Select item 20026090210.

Effect of Replicative Aging on Cryptococcus neoformans

(Submitter supplied) Cryptococcus neoformans (Cn) is an opportunistic fungal microorganism that causes life-threatening meningoencephalitis. During the infection, the microbial population is heterogeneously composed of cells with varying generational ages, with older cells accumulating during chronic infections. This is attributed to their enhanced resistance to phagocytic killing and tolerance of antifungals like fluconazole (FLC). more...

Organism:: Cryptococcus neoformans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28713
4 Samples

Download data: TXT

Series

Accession:: GSE260902

ID:: 200260902

PubMed Full text in PMC Similar studies

Select item 20025384611.

Batf3-Dependent Orchestration of the Robust Th1 Responses and Fungal Control during Cryptococcal Infection, the role of cDC1.

(Submitter supplied) We investigated the role of the cDC1 subset in a fungus-restricting mouse model of cryptococcal infection.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
5 Samples

Download data: MTX, TSV

Series

Accession:: GSE253846

ID:: 200253846

Select item 20023361912.

Fungicide-tolerant persister formation during cryptococcal pulmonary infection

(Submitter supplied) Bacterial persisters, a subpopulation of genetically susceptible cells that are normally dormant and tolerant to bactericides, have been studied extensively because of their clinical importance. In comparison, much less is known about the determinants underlying fungicide-tolerant fungal persister formation in vivo. Here, we report that during mouse lung infection, Cryptococcus neoformans forms persisters that are highly tolerant to amphotericin B (AmB), the standard of care for treating cryptococcosis. more...

Organism:: Cryptococcus neoformans var. grubii H99

Type:: Expression profiling by high throughput sequencing

Platform:: GPL33437
27 Samples

Download data: XLSX

Series

Accession:: GSE233619

ID:: 200233619

Select item 20024898713.

Antifungal activity of the repurposed drug disulfiram against Cryptococcus neoformans.

(Submitter supplied) Fungal infections have become a clinical challenge due to the emergence of drug-resistance of invasive fungi and a rapid increase of novel pathogens. The development of drug resistance has further restricted the use of antifungal agents. Therefore, there is anurgentneedto searchforalternativetreatmentoptions for Cryptococcus neoformans (C. neoformans). Disulfiram (DSF) has a high human safety profile and promising applications as an antiviral, antifungal, antiparasitic, and anticancer agent. more...

Organism:: Cryptococcus neoformans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28713
6 Samples

Download data: TXT

Series

Accession:: GSE248987

ID:: 200248987

PubMed Full text in PMC Similar studies

Select item 20023361214.

Pleiotropic roles of LAMMER kinase, Lkh1 in stress responses and virulence of Cryptococcus neoformans

(Submitter supplied) To investigate the pleiotropic roles of Lkh1 in stress response and virulence, we constructed lkh1∆ mutant strains. In this study, we found that Tor1 was an upstream regulator of Lkh1 in C. neoformans. We then performed gene expression profiling analysis to elucidate signaling circuitry downstream of CnLkh1 in the TOR1-Lkh1 pathway using data obtained from RNA seq of 2 different strains (WT of lkh1∆ mutant) with or without rapamycin treatment.

Organism:: Cryptococcus neoformans var. grubii H99

Type:: Expression profiling by high throughput sequencing

Platform:: GPL33437
12 Samples

Download data: TXT

Series

Accession:: GSE233612

ID:: 200233612

PubMed Full text in PMC Similar studies

Select item 20024584915.

Casein kinase 2 complex: a central regulator of multiple pathobiological signaling pathways in Cryptococcus neoformans

(Submitter supplied) Casein kinase 2 (CK2) is a potential therapeutic target for several human diseases due to its crucial roles in growth, differentiation, and metabolic homeostasis. This study delves into the role of the CK2 complex in Cryptococcus neoformans, a key fungal pathogen causing meningitis. In C. neoformans, the CK2 complex is made up of a main catalytic subunit (Cka1) and two regulatory subunits (Ckb1 and Ckb2). more...

Organism:: Cryptococcus neoformans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21073
9 Samples

Download data: CSV

Series

Accession:: GSE245849

ID:: 200245849

PubMed Full text in PMC Similar studies

Select item 20022354816.

RNA-Seq analysis of HCT-8 cells infected with BCoV and/or Cparvum

(Submitter supplied) Among the causative agents of neonatal diarrhea in calves, two of the most prevalent are bovine coronavirus (BCoV) and Cryptosporidium parvum. Although several studies indicate that co-infections between the two pathogens are associated with greater symptom severity, the host-pathogen interplay remains to be further investigated. The main objective of the present work was to investigate the modulation of the transcriptome of HCT-8 cells during single or co-exposures to BCoV and C. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
48 Samples

Download data: DIFF, TXT

Series

Accession:: GSE223548

ID:: 200223548

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20024351917.

Gene expression profiling of murine macrophages in response to infection with Cryptococcus neoformans yeast cells at distinct physiological states, including the dormant state known as viable but non-culturable (VBNC)

(Submitter supplied) Macrophages play a pivotal role in determining the fate of invading Cryptococcus neoformans cells, and this outcome is highly dependent on how the pathogen modulates phagocyte activation and function. A common consequence of the C. neoformans-host interaction is the establishment of a latent infection, in which the yeast enters a dormant state. In this study, we investigated whether dormant cells could modulate murine bone marrow-derived macrophages (BMDMs) differently from non-dormant cells, thereby providing mechanistic insights into latent infection. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data: TXT, XLSX

Series

Accession:: GSE243519

ID:: 200243519

PubMed Full text in PMC Similar studies

Select item 20018896518.

Brain glucose induces tolerance of Cryptococcus neoformans to amphotericin B during meningitis

(Submitter supplied) In bacteria, antibiotic tolerance, the ability of a susceptible population to survive high doses of cidal drugs, has been shown to compromise therapeutic outcomes. In comparison, whether fungicide tolerance can be induced by host-derived factors during fungal diseases remains unproven. Here, through a systematic evaluation of metabolite-drug-fungal interactions in the leading fungal meningitis pathogen, Cryptococcus neoformans, we found that glucose, on which the brain depends for fuel, induces fungal tolerance to amphotericin B (AmB) in mouse brain tissue and patient cerebrospinal fluid via the fungal glucose repression activator Mig1. more...

Organism:: Cryptococcus neoformans var. grubii H99

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24579
72 Samples

Download data: XLSX

Series

Accession:: GSE188965

ID:: 200188965

PubMed Similar studies SRA Run Selector

Select item 20024178819.

The fungal pathogen Cryptococcus neoformans adapts to the host environment through TOR-mediated remodeling of phospholipid asymmetry

(Submitter supplied) Cryptococcus spp. are environmental fungi that first must adapt to the host environment before they can cause life-threatening meningitis in immunocompromised patients. Host CO2 concentrations are 100-fold higher than the external environment and strains unable to grow at host CO2 concentrations are not pathogenic. Using a genetic screening and transcriptional profiling approach, we found that the TOR pathway is critical for C. more...

Organism:: Cryptococcus neoformans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21073
24 Samples

Download data: XLSX

Series

Accession:: GSE241788

ID:: 200241788

PubMed Full text in PMC Similar studies

Select item 20023243720.

Unbiased discovery of natural sequence variants that influence fungal virulence

(Submitter supplied) Isolates of Cryptococcus neoformans, a fungal pathogen that kills almost 200,000 people worldwide each year, differ at a few thousand up to almost a million DNA sequence positions compared to a 19-megabase reference genome. We used bulked segregant analysis and association analysis, genetic methods that require no prior knowledge of sequence function, to address the key question of which naturally occurring variants influence fungal virulence. more...

Organism:: Cryptococcus neoformans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL27451
16 Samples

Download data: CSV

Series

Accession:: GSE232437

ID:: 200232437

PubMed Similar studies

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