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Items: 1 to 20 of 790

1.

Chromatin-focused genetic and chemical screens identify BRPF1 as a targetable vulnerability in Taxol-resistant triple-negative breast cancer [CRISPR]

(Submitter supplied) Triple-negative breast cancer (TNBC) stands out as a particularly aggressive and frequently recurring form of breast cancer. Due to the absence of hormone receptors, the available treatment avenues are constrained, making chemotherapy the primary approach. Unfortunately, the development of resistance to chemotherapy poses a significant challenge, further restricting the already limited therapeutic alternatives for recurrent cases. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL20301
8 Samples
Download data: TXT
Series
Accession:
GSE262577
ID:
200262577

2.

Gene expression profile in HLA-A02:01-restricted cytotoxic T-cells specific to HTLV-1 in ATL patients

(Submitter supplied) We compared gene expression of CTLs specific to HTLV-1 between the eaarly death group with aggressive disease status and long-term survivors with stable disease status. We then performed gene expression profiling analysis using data obtained from RNA-seq of seven patients with acute ATL in 4, chronic ATL in 2, and an asymptomatic HTLV-1 carrier.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
7 Samples
Download data: XLSX
Series
Accession:
GSE222352
ID:
200222352

Analyze with GEO2R

3.

Gene-to-gene coordinated regulation of transcription and alternative splicing by 3D chromatin remodeling upon NF-κB activation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Other
Platform:
GPL20301
20 Samples
Download data: BED, BEDGRAPH, TXT
Series
Accession:
GSE233889
ID:
200233889

PubMed Full text in PMC Similar studies

4.

Gene-to-gene coordinated regulation of transcription and alternative splicing by 3D chromatin remodeling upon NF-κB activation

(Submitter supplied) The p65/RelA factor of NF-κB plays a pivotal role in coordinating gene expression in response to diverse stimuli, including viral infections. At the chromatin level, p65/RelA governs gene transcription and alternative splicing (AS) through promoter enrichment and genomic exon occupancy, respectively. However, the mechanisms underlying the coordination of these processes remain elusive. In this study, we employed the HTLV-1 Tax viral oncoprotein, a potent activator of NF-κB, to investigate the integrative relationship between 3D chromatin architecture and NF-κB-regulated AS. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL20301
2 Samples
Download data: BED, TXT
Series
Accession:
GSE233888
ID:
200233888

PubMed Full text in PMC Similar studies

5.

Gene-to-gene coordinated regulation of transcription and alternative splicing by 3D chromatin remodeling upon NF-κB activation

(Submitter supplied) The p65/RelA factor of NF-κB plays a pivotal role in coordinating gene expression in response to diverse stimuli, including viral infections. At the chromatin level, p65/RelA governs gene transcription and alternative splicing (AS) through promoter enrichment and genomic exon occupancy, respectively. However, the mechanisms underlying the coordination of these processes remain elusive. In this study, we employed the HTLV-1 Tax viral oncoprotein, a potent activator of NF-κB, to investigate the integrative relationship between 3D chromatin architecture and NF-κB-regulated AS. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL20301
18 Samples
Download data: BEDGRAPH
Series
Accession:
GSE233887
ID:
200233887

PubMed Full text in PMC Similar studies

6.

Next Generation Sequencing of transcriptomes in GFP+-HSCs sorted from bone marrow of mice receiving HSCs subjected to control RNA or miR-31-5p inhibitor treatment.

(Submitter supplied) Purpose: The goals of this study is to uncover the difference of transcriptomes that are essential for HSCs malignant transformation driven by miR-31-5p inhibition. Methods: GFP+-HSCs sorted from bone marrow mRNA profiles of mice receiving HSCs subjected to control RNA or miR-31-5p inhibitor treatment were generated by deep sequencing, using Illumina NovaSeq 6000 sequencer for 318 cycles.Reads that passed the Illumina quality filters were kept for the subsequent analyses. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
6 Samples
Download data: TXT
Series
Accession:
GSE163985
ID:
200163985

SRA Run Selector

7.

Next Generation Sequencing of WT, ORP4L KI, Wild-type, LCK/R26Tax, ORP4Lcko;LCK/R26Tax T-cells Transcriptomes.

(Submitter supplied) Purpose: The goals of this study is to uncover the cellular pathways that are essential for T-cell malignant transformation driven by ORP4L and HTLV-1 oncogene Tax. Methods: T-cell mRNA profiles of WT, ORP4L KI, Wild-type, LCK/R26Tax, ORP4Lcko;LCK/R26Tax mice were generated by deep sequencing, using Illumina NovaSeq 6000 sequencer for 318 cycles.Reads that passed the Illumina quality filters were kept for the subsequent analyses. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
16 Samples
Download data: TXT
Series
Accession:
GSE162074
ID:
200162074

SRA Run Selector

8.

Identification of LGR6-associated genes in NSCLC

(Submitter supplied) mRNA seq analysis comparing the expression profiles of siRNA-mediated LGR6-silenced and LGR6-retained NSCLC cell lines harboring CTNNB1 exon 3 mutations identified several LGR6-related genes that have been associated with cancer development and stemness properties.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
6 Samples
Download data: TXT
Series
Accession:
GSE218163
ID:
200218163

PubMed Full text in PMC Similar studies Analyze with GEO2R

9.

Evaluating Cancer Subtypes and Enhancer Dynamics During the Acquisition of Drug Resistance by Nascent RNA-Sequencing

(Submitter supplied) Precision Run-On Sequencing (PRO-seq) was performed on triple negative breast cancer (TNBC) cell lines and drug resistant cell lines to determine the epigenetic factors that contribute to TNBC subtypes and drug resistance.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
19 Samples
Download data: BW
Series
Accession:
GSE206324
ID:
200206324

Analyze with GEO2R

10.

Identification of Wnt target genes associated with malignant phenotypes in CTNNB1-mutated NSCLC

(Submitter supplied) Microarray analysis comparing the expression profiles of siRNA-mediated CTNNB1-silenced and CTNNB1-retained HCC15 cells harboring a homozygous CTNNB1 S45F mutation revealed that besides several known Wnt genes, LGR6 was significantly downregulated by CTNNB1 knockdown in HCC15 cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
2 Samples
Download data: CEL
Series
Accession:
GSE183178
ID:
200183178

PubMed Full text in PMC Similar studies Analyze with GEO2R

11.

Potential Role of HTLV-1 Tax-Specific Cytotoxic T Lymphocytes expressing a Unique T-cell Receptor to Promote Inflammation of the Central Nervous System in Myelopathy Associated with HTLV-1

(Submitter supplied) We performed immunoprofiling of HTLV-1 Tax301-309 (SFHSLHLLF) specific CD8+ T cells in PB of HAM patients associated with T cell activation by single cell RNA sequencing (scRNA-seq).
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
3 Samples
Download data: CSV, XLSX
Series
Accession:
GSE210786
ID:
200210786

PubMed Full text in PMC Similar studies

12.

Time-course of host cell transcription during the HTLV-1 transcriptional burst

(Submitter supplied) We report the host cell transcription during the phases of the HTLV-1 plus-strand burst.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
16 Samples
Download data: RESULTS
Series
Accession:
GSE197110
ID:
200197110

PubMed Full text in PMC Similar studies Analyze with GEO2R

13.

Epigenetic repression of STING by MYC promotes immune evasion and resistance to immune checkpoint inhibitors in triple negative breast cancer.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL24676 GPL18573 GPL24247
59 Samples
Download data: BW
Series
Accession:
GSE196325
ID:
200196325

14.

Epigenetic repression of STING by MYC promotes immune evasion and resistance to immune checkpoint inhibitors in triple negative breast cancer [CHIP-seq]

(Submitter supplied) The MYC oncogene is frequently amplified in triple negative breast cancer (TNBC). Here, we show that MYC suppression induces immune-related hallmark gene set signatures and tumor infiltrating T cells in MYC-hyperactivated TNBCs. Mechanistically, MYC repressed stimulator of interferon genes (STING) expression via direct binding to the STING enhancer region, resulting in downregulation of the T cell chemokines CCL5, CXCL10 and CXCL11. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18573
4 Samples
Download data: BW
Series
Accession:
GSE196324
ID:
200196324

15.

Epigenetic repression of STING by MYC promotes immune evasion and resistance to immune checkpoint inhibitors in triple negative breast cancer [RNA-seq]

(Submitter supplied) The MYC oncogene is frequently amplified in triple negative breast cancer (TNBC). Here, we show that MYC suppression induces immune-related hallmark gene set signatures and tumor infiltrating T cells in MYC-hyperactivated TNBCs. Mechanistically, MYC repressed stimulator of interferon genes (STING) expression via direct binding to the STING enhancer region, resulting in downregulation of the T cell chemokines CCL5, CXCL10 and CXCL11. more...
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL18573 GPL24676 GPL24247
55 Samples
Download data: TXT
Series
Accession:
GSE196323
ID:
200196323

16.

Highly selective HSP90 inhibitor, pimitespib, demonstrates its potent growth suppressive activity to adult T-cell leukemia in preclinical models (Su9T01).

(Submitter supplied) Adult T-cell leukaemia-lymphoma (ATL) is a highly chemoresistant malignancy of peripheral T lymphocytes caused by human T-lymphotropic virus type I (HTLV-1). ATL cells constitutively activate anti-apoptotic signals through nuclear factor kappaB (NF-κB)-mediated gene expression. The molecular chaperon heat shock protein 90 (HSP90) plays a crucial role on NF-κB-mediated anti-apoptotic activity in ATL cells and HSP90 inhibitors, such as 17-DMAG and NVP-AUY922, have demonstrated their anti-ATL activities. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17077
6 Samples
Download data: TXT
Series
Accession:
GSE168558
ID:
200168558

PubMed Full text in PMC Similar studies Analyze with GEO2R

17.

Highly selective HSP90 inhibitor, pimitespib, demonstrates its potent growth suppressive activity to adult T-cell leukemia in preclinical models (Pt1-3).

(Submitter supplied) Adult T-cell leukaemia-lymphoma (ATL) is a highly chemoresistant malignancy of peripheral T lymphocytes caused by human T-lymphotropic virus type I (HTLV-1). ATL cells constitutively activate anti-apoptotic signals through nuclear factor kappaB (NF-κB)-mediated gene expression. The molecular chaperon heat shock protein 90 (HSP90) plays a crucial role on NF-κB-mediated anti-apoptotic activity in ATL cells and HSP90 inhibitors, such as 17-DMAG and NVP-AUY922, have demonstrated their anti-ATL activities. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16699
6 Samples
Download data: TXT
Series
Accession:
GSE168557
ID:
200168557

PubMed Full text in PMC Similar studies Analyze with GEO2R

18.

Highly selective HSP90 inhibitor, pimitespib, demonstrates its potent growth suppressive activity to adult T-cell leukemia in preclinical models (OATL4).

(Submitter supplied) Adult T-cell leukaemia-lymphoma (ATL) is a highly chemoresistant malignancy of peripheral T lymphocytes caused by human T-lymphotropic virus type I (HTLV-1). ATL cells constitutively activate anti-apoptotic signals through nuclear factor kappaB (NF-κB)-mediated gene expression. The molecular chaperon heat shock protein 90 (HSP90) plays a crucial role on NF-κB-mediated anti-apoptotic activity in ATL cells and HSP90 inhibitors, such as 17-DMAG and NVP-AUY922, have demonstrated their anti-ATL activities. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17077
6 Samples
Download data: TXT
Series
Accession:
GSE168556
ID:
200168556

PubMed Full text in PMC Similar studies Analyze with GEO2R

19.

Highly selective HSP90 inhibitor, pimitespib, demonstrates its potent growth suppressive activity to adult T-cell leukemia in preclinical models (LYM1, KK1).

(Submitter supplied) Adult T-cell leukaemia-lymphoma (ATL) is a highly chemoresistant malignancy of peripheral T lymphocytes caused by human T-lymphotropic virus type I (HTLV-1). ATL cells constitutively activate anti-apoptotic signals through nuclear factor kappaB (NF-κB)-mediated gene expression. The molecular chaperon heat shock protein 90 (HSP90) plays a crucial role on NF-κB-mediated anti-apoptotic activity in ATL cells and HSP90 inhibitors, such as 17-DMAG and NVP-AUY922, have demonstrated their anti-ATL activities. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16699
14 Samples
Download data: TXT
Series
Accession:
GSE168555
ID:
200168555

PubMed Full text in PMC Similar studies Analyze with GEO2R

20.

Highly selective HSP90 inhibitor, pimitespib, demonstrates its potent growth suppressive activity to adult T-cell leukemia in preclinical models (HuT102).

(Submitter supplied) Adult T-cell leukaemia-lymphoma (ATL) is a highly chemoresistant malignancy of peripheral T lymphocytes caused by human T-lymphotropic virus type I (HTLV-1). ATL cells constitutively activate anti-apoptotic signals through nuclear factor kappaB (NF-κB)-mediated gene expression. The molecular chaperon heat shock protein 90 (HSP90) plays a crucial role on NF-κB-mediated anti-apoptotic activity in ATL cells and HSP90 inhibitors, such as 17-DMAG and NVP-AUY922, have demonstrated their anti-ATL activities. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17077
6 Samples
Download data: TXT
Series
Accession:
GSE168554
ID:
200168554

PubMed Full text in PMC Similar studies Analyze with GEO2R

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