GEO DataSets

(Submitter supplied) DUX4 is a germline transcription factor and a master regulator of zygotic genome activation. During early embryogenesis, DUX4 is crucial for maternal to zygotic transition at the 8-cell stage in order to overcome silencing of genes and enable transcription from the zygotic genome. In adult somatic cells, DUX4 expression is silenced and its activation in adult muscle cells causes the genetic disorder Facioscapulohumeral Muscular Dystrophy (FSHD). more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing; Other

Platform:

GPL24676

80 Samples

Download data: BW, FA, GTF, TSV, TXT

(Submitter supplied) Attenuating Hypoxia Driven Malignant Behavior in Glioblastoma with a Novel Hypoxia-Inducible Factor 2 Alpha Inhibitor

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL9052

10 Samples

Download data: XLSX

(Submitter supplied) 4plex_maize_2015_02 - cinetique comparison - Delineation of the metabolic pathways involved in maize endosperm vitreousness. - comparaison of vitreous (outer) and floury (inner) endosperm from flint and dent maize inbred lines harvested at 15 and 20 day after pollinisation.

Organism:

Zea mays

Type:

Expression profiling by array

Platform:

GPL22405

16 Samples

Download data: GPR

(Submitter supplied) Analysis of adult retinas from tripartite motif-containing domain 9 knockouts and wild type littermates. Trim9 belongs to the TRIM family of E3 ubiquitin ligases. Results provide insight into possible roles for Trim9 in the retina.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

6 Samples

Download data: CEL, CHP

(Submitter supplied) 4plex_physco_2014-05 - ppmax2 response to gr24 - How does the Ppmax2 moss mutant respond to Strigolactone (GR24)? - Two moss genotypes are used: WT and the Ppmax2 mutant. Moss tissues are fragmented, then plated on medium (Petri dish with cellophane disks) and cultivated for 3 weeks. Moss tissues are then transfered for 6 hours on acetone-containing medium (control treatment, for WT and Ppmax2) or GR24 (1 microM, in acetone)-containing medium (for Ppmax2). more...

Organism:

Physcomitrium patens

Type:

Expression profiling by array

Platform:

GPL21755

8 Samples

Download data: GPR

(Submitter supplied) Among animals at risk for excessive ethanol consumption such as the HDID selected lines, there is considerable individual variation in the amount of ethanol consumed and the associated blood ethanol concentrations (BECs). For the HDID lines, this variation occurs even though the residual genetic variation associated with the DID phenotype has been largely exhausted and thus is most likely associated with epigenetic factors. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

69 Samples

Download data: XLSX

(Submitter supplied) TMPRSS2:ERG (T/E) gene fusions are detectable in approximately 50% of all prostate cancer cases and can be considered as biomarkers for molecular subtypes. Several T/E variants have been identified and expression of specific fusion mRNAs was associated with adverse clinicopathologic parameters. However, the underlying molecular processes induced by distinct T/E variants still remain unclear. We therefore aimed to characterize the molecular and cellular profile and specific transcriptional modulation induced by different T/E gene fusion variants.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

12 Samples

Download data: TXT

(Submitter supplied) 4plex_maize_2015_02 - albumen vitreux vs albumen farineux - Delineation of the metabolic pathways involved in maize endosperm vitreousness. - Comparison of vitreous (outer) and floury (inner) endosperm from flint and dent maize inbred lines harvested at 15 and 20 day after pollination.

Organism:

Zea mays subsp. mays; Zea mays

Type:

Expression profiling by array

Platform:

GPL22405

16 Samples

Download data: GPR

(Submitter supplied) We used RNA sequencing to characterize gene expression of CD4+ CD8α+ double positive (DP), Foxp3+ Treg (TR) and CD4+ single positive (SP) cells in the lamina propria (LP) and intraepithelial compartment (IEL) that had differentiante from the same clonal transnuclear (TN) precursor.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

18 Samples

Download data: TXT

(Submitter supplied) The comparability of gene expression between blood and brain tissues is a central issue in neuropsychiatric research where the analysis of molecular mechanisms in the brain is of high importance for the understanding of the diseases and the discovery of biomarkers. However, the accessibility of brain tissue is limited. Therefore, knowledge about how easily accessible peripheral tissue, e.g. blood, is comparable to and reflects the mechanisms of the brain will help to advance neuropsychiatric research. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6247

9 Samples

Download data: CEL

(Submitter supplied) The four mammalian Argonaute family members are thought to share redundant functions in the microRNA pathway, yet only AGO2 possesses the catalytic "slicer" function required for RNA interference. Whether AGO1, AGO3, or AGO4 possess specialized functions remains unclear. Here, we Series_summary = show that AGO4 localizes to spermatocyte nuclei during meiotic prophase I, specifically at sites of asynapsis and in the transcriptionally silenced XY sub-domain, the sex body. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL15103 GPL9250

10 Samples

Download data: TXT

(Submitter supplied) Barley florets (cv. Morex) were treated with 2.0 microgram deoxynivalenol per floret via a 10 microliter solution or mock inoculated with water. Samples were collected at 1, 12, 24, and 48 hours after inoculation. ****[PLEXdb(http://www.plexdb.org) has submitted this series at GEO on behalf of the original contributor, Stephanie A. Gardiner. The equivalent experiment is BB62 at PLEXdb.]

Organism:

Hordeum vulgare

Type:

Expression profiling by array

Platform:

GPL1340

24 Samples

Download data: CEL

(Submitter supplied) This study was designed to identify changes in gene expression when corn was placed under various related stresses including being grown with a competing weed (canola) to the V4 or V8 stage, or when 40% shade cloth was present to the V4 or V8 stage, or under low nitrogen (no added nitrogen fertilizer), or under weed/shade free fertilized control conditions. In all 5 treatments and the control, samples were harvested at V8. more...

Organism:

Zea mays

Type:

Expression profiling by array

Platform:

GPL6438

36 Samples

Download data: TXT

(Submitter supplied) To learn more about the global effects of phosphatidylcholine (PC)-deficiency in A. tumefaciens, we performed transcriptomic studies comparing the wild type and a PC-deficient DpmtA Dpcs mutant. We expanded the number of affected virulence genes and showed that the loss of PC was correlated with altered expression of multiple genes encoding membrane or membrane-associated proteins and proteins which fulfil their function at the membrane. more...

Organism:

Agrobacterium fabrum str. C58

Type:

Expression profiling by array

Platform:

GPL10294

12 Samples

Download data: TXT

(Submitter supplied) Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness and attacks of muscle atonia triggered by strong emotions (cataplexy). The best biological marker of narcolepsy is orexin deficiency with dramatic loss in hypothalamic orexin-producing neurons. Together with a tight HLA and T-cell receptor alpha(5) association, narcolepsy is believed to be autoimmune although all attempts to prove it have failed.To characterize orexin specific peptides we produced a transgenic mouse model to access to the orexin neurons transcription profile. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

18 Samples

Download data: CEL

(Submitter supplied) We sought to confirm the genetic influence in the development of Ventilation-Associated Lung Injury (VALI) and, in the process, identify potential candidate genes involved in the disease by integrating differential gene expression profiling on rat lungs to a traditional strain survey analysis of the parental rat strains, VALI-sensitive Brown Norway rats versus VALI-resistant Dahl Salt Sensitive rats, comparing control (under room air ventilation) versus under high tidal volume (HTV) ventilation. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2709

Platform:

GPL1355

12 Samples

Download data: CEL

Analysis of lungs from 2 strains exposed to high tidal volume mechanical ventilation. Examined strains consist of one that is resistant to ventilator-associated lung injury (VALI) and another that is sensitive. Results provide insight into the genetic basis of susceptibility to VALI.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol, 2 strain sets

Platform:

GPL1355

Series:

GSE7041

12 Samples

Download data: CEL

(Submitter supplied) This study aims to identify all genes expressed in primary mouse megakaryocytes Keywords: Megakaryocyte, SAGE, transcriptome analysis

Organism:

Mus musculus

Type:

Expression profiling by SAGE

Platform:

GPL1349

1 Sample

Download data

(Submitter supplied) In rodent models, phthalate exposure alters both the fetal and pubertal testis, but the resulting histopathological changes are divergent. This suggests that the underlying molecular and cellular phthalate mechanism may be age-dependent. Using genome-wide expression profiling of acutely-exposed rats, the initial molecular response in pubertal rat testis following in vivo phthalate exposure was determined. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1881

Platform:

GPL1355

30 Samples

Download data

Analysis of testes of postnatal day 28 animals at various time points up to 12 hrs after acute exposure to mono-(2-ethylhexyl) phthalate. Phthalate plasticizers can damage fetal and prepubertal testis. Results provide insight into mechanisms of prepubertal phthalate-induced testicular injury.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 5 time sets

Platform:

GPL1355

Series:

GSE4514

30 Samples

Download data