myositis koelzii - GEO DataSets

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Select item 2002607861.

(Submitter supplied) We performed bulk RNA transcriptomics of skeletal muscle samples from patients with idiopathic inflammatory myopathies.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
29 Samples

Download data: XLSX

Series

Accession:: GSE260786

ID:: 200260786

PubMed Similar studies

Select item 2002433392.

Clues to Drivers of Juvenile Dermatomyositis: Genetic Alterations after Type I Interferon and JAK Inhibitor Treatment in Pediatric Bioengineered Skeletal Muscle

(Submitter supplied) To better understand the pathogenesis of juvenile dermatomyositis (JDM) we examined the genetic alterations that result from exogenous IFN I exposure in pediatric skeletal muscle. We compared untreated healthy pediatric donor-derived myobundles with those treated with IFN I as well as with JAKi baricitinib and tofacitinib. We used bulk mRNA sequencing to evaluate how IFN I and treatment with JAKi influence healthy and JDM skeletal muscle gene expression and show IFNβ leads to a greater pro-inflammatory gene response than IFNα in pediatric skeletal muscle. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
83 Samples

Download data: CSV

Series

Accession:: GSE243339

ID:: 200243339

PubMed Similar studies

Select item 2002453143.

Muscle Inflammation is Regulated by NF-kB From Multiple Cells to Muscle Inflammation is Regulated by NF-kB From Multiple Cells to Control Distinct States of Wasting in Cancer Cachexia

(Submitter supplied) Although cancer cachexia is classically characterized as a systemic inflammatory disorder, emerging evidence indicates that weight loss also associates with local tissue inflammation. We queried the regulation of this inflammation and its causality to cachexia by exploring skeletal muscle, whose atrophy strongly associates with poor outcomes. Using multiple mouse models and patient samples, we show that cachectic muscle is marked by enhanced innate immunity. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
6 Samples

Download data: TXT

Series

Accession:: GSE245314

ID:: 200245314

Select item 2002730944.

Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and remodeling (Zfp697 transduced primary mouse myotubes ChIP-Seq)

(Submitter supplied) Muscle atrophy is a morbidity and mortality risk factor that happens with disuse, chronic disease, and ageing. Recovery from atrophy involves changes in protein synthesis and different cell types such as muscle fibers, and satellite and immune cells. Here we show that the previously uncharacterized gene and protein Zfp697 is a damage-induced regulator of muscle regeneration. Zfp697/ZNF697 expression is transiently elevated during recovery from muscle atrophy or injury in mice and humans. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21626
7 Samples

Download data: BW, TXT

Series

Accession:: GSE273094

ID:: 200273094

Select item 2002730935.

Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and remodeling (Zfp697 transduced primary mouse myotubes RNA-Seq)

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: TXT

Series

Accession:: GSE273093

ID:: 200273093

Select item 2002730926.

Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and remodeling (Zfp697 skeletal muscle knockout RNA-Seq of unloading-reloading protocol)

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
18 Samples

Download data: TXT

Series

Accession:: GSE273092

ID:: 200273092

Select item 2002720477.

Integrative genomic, virulence, and transcriptomic analysis of emergent Streptococcus dysgalactiae subspecies equisimilis (SDSE) emm type stG62647 isolates causing human infections

(Submitter supplied) Streptococcus dysgalactiae subspecies equisimilis (SDSE) is a Gram-positive bacterial pathogen that infects humans and is closely related to group A streptococcus (GAS). Compared to GAS, far less is known about SDSE pathobiology. Increased rates of invasive SDSE infections have recently been reported in many countries. One SDSE emm type, stG62647, is known to cause severe diseases, including necrotizing soft-tissue infections, endocarditis, and osteoarticular infections. more...

Organism:: Streptococcus dysgalactiae subsp. equisimilis

Type:: Expression profiling by high throughput sequencing

Platform:: GPL34696
114 Samples

Download data: TXT, XLSX

Series

Accession:: GSE272047

ID:: 200272047

PubMed Similar studies

Select item 2001564668.

RNA-Seq of peripheral blood in FOP patients

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
11 Samples

Download data

Series

Accession:: GSE156466

ID:: 200156466

Select item 2001564649.

Single cell RNA-sequencing of PBMCs in FOP patients

(Submitter supplied) We described a genetic map of PBMCs in FOP patients by using single-cell RNA sequencing for the first time.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
6 Samples

Download data: RDS

Series

Accession:: GSE156464

ID:: 200156464

SRA Run Selector

Select item 20015645910.

RNA-sequencing of peripheral blood in FOP patients

(Submitter supplied) We combined the results of scRNA-seq of PBMCs with total RNA sequencing of peripheral blood to find out the most remarkable different subgroup and the corresponding DEGs.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
5 Samples

Download data: TXT

Series

Accession:: GSE156459

ID:: 200156459

SRA Run Selector

Select item 20022725311.

Palovarotene action against heterotopic ossification includes the inhibition of local participating activin A-expressing cell populations

(Submitter supplied) Heterotopic ossification (HO) consists of endochondral bone forming at extraskeletal anatomical sites. One form of HO is acquired and instigated by traumas or invasive surgery, and another form is genetic and severe and characterizes patients with Fibrodysplasia Ossificans Progressiva (FOP). Previously, we showed that the synthetic retinoid agonist Palovarotene inhibits both acquired and genetic HO, and we and others subsequently showed that systemic administration of a neutralizing activin A antibody reduces both HO forms as well. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
1 Sample

Download data: MTX, TSV

Series

Accession:: GSE227253

ID:: 200227253

PubMed Full text in PMC Similar studies

Select item 20026235212.

Spatial transcriptome analysis of muscle sections from Icos-/- NOD mice with established myositis

(Submitter supplied) Icos-/- NOD mice are a model of spontaneous myositis. By using Nanostring GeoMx technology (Mouse WTA), we aimed to investigate the differences in gene expression between myofibers of Icos+/+ NOD (WT) mice and myofibers from Icos-/- NOD mice either in direct contact or not with large infiltrate clusters.

Organism:: Mus musculus

Type:: Other

Platform:: GPL24247
26 Samples

Download data: DCC, PKC, XLSX

Series

Accession:: GSE262352

ID:: 200262352

PubMed Full text in PMC Similar studies

Select item 20023751213.

PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification

(Submitter supplied) Heterotopic ossification (HO) occurs following mechanical trauma, burns, or congenitally in patients suffering from fibrodysplasia ossificans progressiva (FOP). Recently, we demonstrated that inhibitors of phosphatidyl-inositol 3-kinase alpha (PI3Kα), including the already marketed BYL719/Alpelisib/Piqray, may become a useful therapy for patients undergoing HO. In this study, we have confirmed these results and optimized the timing of administration of BYL719. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
39 Samples

Download data: CSV

Series

Accession:: GSE237512

ID:: 200237512

Analyze with GEO2R

Select item 20022614714.

Modeling of Clinical Phenotypes in Systemic Lupus Erythematosus Based on the Platelet Transcriptome and FCGR2a Genotype

(Submitter supplied) Background: The clinical heterogeneity of SLE with its complex pathogenesis remains challenging as we strive to provide optimal management. The contribution of platelets to endovascular homeostasis, inflammation and immune regulation highlights their potential importance in SLE. Prior work from our group showed that the Fcγ receptor type IIa (FcγRIIa)–R/H131 biallelic polymorphism is associated with increased platelet activity and cardiovascular risk in SLE. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
69 Samples

Download data: TXT

Series

Accession:: GSE226147

ID:: 200226147

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20022112815.

Oxidative phosphorylation is a pivotal therapeutic target of fibrodysplasia ossificans progressiva

(Submitter supplied) Heterotopic ossification (HO) is a non-physiological process of bone formation in which progenitor cells in soft tissues differentiate into chondrogenic cells. In the case of fibrodysplasia ossificans progressiva (FOP), a rare genetic disease characterized by progressive and systemic HO, the Activin A/mutated-ACVR1/mTORC1 cascade induces HO in progenitors, one of which is the fibro/adipogenic progenitors (FAPs) in muscle tissues. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21697
11 Samples

Download data: TXT

Series

Accession:: GSE221128

ID:: 200221128

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20022072516.

Oxidative phosphorylation is a pivotal therapeutic target of fibrodysplasia ossificans progressiva

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
21 Samples

Download data: TXT

Series

Accession:: GSE220725

ID:: 200220725

PubMed Full text in PMC Similar studies

Select item 20024862517.

Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8 Develop Severe Myocarditis and Myositis in Response to Anti–PD-1 Immune Checkpoint Inhibitor Cancer Therapy

(Submitter supplied) Myocarditis has emerged as an immune-related adverse event of immune-checkpoint inhibitor (ICI) cancer therapy associated with significant mortality. Our new NOD-cMHCI/II-/-.DQ8 mouse strain expresses human HLA-DQ8 in the absence of classical murine MHC class I and II. These mice are highly susceptible to myocarditis and acute heart failure following anti-PD-1 ICI-induced treatment. Additionally, anti-PD-1 administration accelerates skeletal muscle myositis development. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
13 Samples

Download data: TXT

Series

Accession:: GSE248625

ID:: 200248625

PubMed Similar studies

Select item 20025187218.

Deep phenotyping of Post-infectious Myalgic Encephalomyelitis/Chronic Fatigue Syndrome [PBMC RNA-Seq]

(Submitter supplied) Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling disorder that may occur following an infection, yet the clinical phenotype is poorly defined, the pathophysiology is unknown, and no disease-modifying treatments are available. We used rigorous criteria to recruit a cohort of post-infectious ME/CFS (PI-ME/CFS) volunteers (n=17) with matched healthy controls (n=21) to conduct deep clinical and biological phenotyping using an extensive battery of tests. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL21290
27 Samples

Download data: TXT

Series

Accession:: GSE251872

ID:: 200251872

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20024329119.

Spatial transcriptomics reveal signatures of histopathological changes in muscular sarcoidosis

(Submitter supplied) Sarcoidosis is a multisystemic disease characterized by non-caseating granuloma infiltrating various organs. The form with symptomatic muscular involvement is called muscular sarcoidosis. The impact of immune cells composing the granuloma on the skeletal muscle is misunderstood. Here, we investigated the granuloma-skeletal muscle interactions through spatial transcriptomics. Five major transcriptomic clusters corresponding to perigranuloma, granuloma, and three successive muscle tissue areas (proximal, intermediate and distal) around the granuloma were identified. more...