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Items: 4

1.

The structural basis for cohesin/CTCF anchored loops [Hi-C]

(Submitter supplied) Cohesin catalyses the folding of the genome into loops that are anchored by CTCF. The molecular mechanism of how cohesin and CTCF structure the 3D genome has remained unclear. Here we show that a segment within the CTCF N terminus interacts with the SA2-SCC1 subunits of cohesin. A 2.6 Å crystal structure of SA2-SCC1 in complex with CTCF reveals the molecular basis of the interaction. We demonstrate that this interaction is specifically required for CTCF-anchored loops and contributes to the positioning of cohesin at CTCF-binding sites. more...
Organism:
Homo sapiens
Type:
Other
Platforms:
GPL21697 GPL24676
6 Samples
Download data: TXT
Series
Accession:
GSE126636
ID:
200126636
2.

The structural basis for cohesin/CTCF anchored loops

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
Platforms:
GPL21697 GPL24676 GPL16791
16 Samples
Download data: NARROWPEAK, TXT
Series
Accession:
GSE126637
ID:
200126637
3.

NextSeq 550 (Homo sapiens)

Platform
Accession:
GPL21697
ID:
100021697
4.

Hi-C_WT 2.1

Organism:
Homo sapiens
Source name:
HAP1
Platform:
GPL21697
Series:
GSE126636 GSE126637
Download data
Sample
Accession:
GSM4052982
ID:
304052982
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Supplemental Content

db=gds|term=GSM4052982[Accession]|query=1|qty=2|blobid=MCID_6625816f4c13c13a066d7cd4|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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