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Items: 4

1.

Response to estradiol-ERalpha, estradiol-Erbeta, and ERE Binding defective mutants

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
36 Samples
Download data: CEL
Series
Accession:
GSE9761
ID:
200009761
2.

Response to estradiol-ERbeta and estradiol-ERbeta ERE binding defective mutant

(Submitter supplied) In addition to the estrogen responsive element (ERE)-dependent gene expression, E2-ERbeta regulates transcription through functional interactions with transfactors bound to their cognate regulatory elements on DNA, hence the ERE-independent signaling pathway. However, the relative importance of the ERE-independent pathway in E2-ERbeta signaling is unclear. Our studies in infected ER-negative cell models with an ERbeta mutant (ERbetaDBD) that functions exclusively at the ERE-independent pathway demonstrated that genomic responses assessed by microarrays from the ERE-independent pathway to E2-ERbeta are not sufficient to alter cellular growth, death or motility. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
18 Samples
Download data: CEL
Series
Accession:
GSE9759
ID:
200009759
3.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...
Organism:
Homo sapiens
602 DataSets
5646 Series
61 Related Platforms
171199 Samples
Download data
Platform
Accession:
GPL570
ID:
100000570
4.

Erb rep 1

Organism:
Homo sapiens
Source name:
infected with recombinant adenovirus bearing cDNA for ERbeta; rep1
Platform:
GPL570
Series:
GSE9759 GSE9761
Download data: CEL
Sample
Accession:
GSM246297
ID:
300246297
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