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Items: 4

1.

Runx1 targets in early B-cell progenitors

(Submitter supplied) The t(12;21) chromosomal translocation, targeting the gene encoding the RUNX1 transcription factor, is observed in 25% of pediatric acute lymphoblastic leukemia (ALL) and is an initiating event in the disease. To elucidate the mechanism by which RUNX1 disruption initiates leukemogenesis, we investigated its normal role in murine B-cell development. Gene expression analysis and genome-wide Runx1-occupancy studies support the hypothesis that Runx1 reinforces the transcription factor network in B-cell progenitors governing early B-cell survival and development .
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array
Platforms:
GPL11202 GPL11002 GPL7202
10 Samples
Download data: TXT
Series
Accession:
GSE45425
ID:
200045425
2.

Gene expression analysis to identify Runx1 target genes in B-cell progenitors

(Submitter supplied) The t(12;21) chromosomal translocation, targeting the gene encoding the RUNX1 transcription factor, is observed in 25% of pediatric acute lymphoblastic leukemia (ALL) and is an initiating event in the disease. To elucidate the mechanism by which RUNX1 disruption initiates leukemogenesis, we investigated its normal role in murine B-cell development. Gene expression analysis and genome-wide Runx1-occupancy studies support the hypothesis that Runx1 reinforces the transcription factor network in B-cell progenitors governing early B-cell survival and development .
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL7202 GPL11202
8 Samples
Download data: TXT
Series
Accession:
GSE45424
ID:
200045424
3.

Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)

(Submitter supplied) Designed to truly represent all known genes in the mouse genome and their resulting transcripts, Agilent's Whole Mouse Genome Oligo – 4X44K microarray is comprised of 41,534 60-mer oligonucleotide probes representing over 41,000 mouse genes and transcripts. Content for this microarray was generated from leading public databases, including RefSeq, RIKEN, NIA, Ensembl, RIKEN, UCSC Goldenpath, and Unigene. more...
Organism:
Mus musculus
16 DataSets
652 Series
1 Related Platform
10662 Samples
Download data
Platform
Accession:
GPL7202
ID:
100007202
4.

sorted proB_k.o._rep2

Organism:
Mus musculus
Source name:
sorted proB_knockout mice_replicate2
Platform:
GPL7202
Series:
GSE45424 GSE45425
Download data: TXT
Sample
Accession:
GSM1104073
ID:
301104073
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