GSM1104073[Accession] - GEO DataSets

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Items: 4

Select item 2000454251.

Runx1 targets in early B-cell progenitors

(Submitter supplied) The t(12;21) chromosomal translocation, targeting the gene encoding the RUNX1 transcription factor, is observed in 25% of pediatric acute lymphoblastic leukemia (ALL) and is an initiating event in the disease. To elucidate the mechanism by which RUNX1 disruption initiates leukemogenesis, we investigated its normal role in murine B-cell development. Gene expression analysis and genome-wide Runx1-occupancy studies support the hypothesis that Runx1 reinforces the transcription factor network in B-cell progenitors governing early B-cell survival and development .

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL11202 GPL7202 GPL11002
10 Samples

Download data: TXT

Series

Accession:: GSE45425

ID:: 200045425

Select item 2000454242.

Gene expression analysis to identify Runx1 target genes in B-cell progenitors

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL11202 GPL7202
8 Samples

Download data: TXT

Series

Accession:: GSE45424

ID:: 200045424

Select item 1000072023.

Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)

(Submitter supplied) Designed to truly represent all known genes in the mouse genome and their resulting transcripts, Agilent's Whole Mouse Genome Oligo – 4X44K microarray is comprised of 41,534 60-mer oligonucleotide probes representing over 41,000 mouse genes and transcripts. Content for this microarray was generated from leading public databases, including RefSeq, RIKEN, NIA, Ensembl, RIKEN, UCSC Goldenpath, and Unigene. more...