GEO DataSets

(Submitter supplied) Serine protease inhibitor Kazal type 3 (Spink3) is a trypsin inhibitor in the pancreas. Spink3-/- pancreatic acinar cells are dead with excessive autophagy at birth (p0.5). To prove the role of nonapoptotic cell death with autophagy, we generated by transgenic technology the pancreas of Spink3-/-;XKI/+ mice contained both normal and dying acinar cells with autophagy. In this new mouse model, chronic inflammation occurred in the pancreas, indicating that some signals from nonapoptotic dead cell induce chronic inflammation in the pancreas.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13912

6 Samples

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(Submitter supplied) Design ID: 028005 Build version: mm9:NCBI37:Jul2007 Arrays of this design have barcodes that begin with 16028005 or 2528005. Orientation: Features are numbered numbered Left-to-Right, Top-to-Bottom as scanned by an Agilent scanner (barcode on the left, DNA on the back surface, scanned through the glass), matching the FeatureNum output from Agilent's Feature Extraction software. The ID column represents the Agilent Feature Extraction feature number. more...

Organism:

Mus musculus

474 Series

1 Related Platform

5711 Samples

Download data: TXT