GSE107854[Accession] - GEO DataSets - NCBI

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Items: 17

Select item 2001078541.

PRMT5 regulates the homologous recombination DNA repair pathway by controlling the alternative splicing of key epigenetic factors

(Submitter supplied) We found that PRMT5 deletion or inhibition impairs homologous recombination (HR) DNA repair, leading to DNA damage accumulation, p53 activation, cell cycle arrest and cell death through missplicing of KAT5. We show that PRMT5 inhibitors and PARP inhibitors have synergistic effects on human acute leukemia cell lines, demonstrating the advantages of combining targeted epigenetic and non-epigenetic inhibitors.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL19057 GPL13112
14 Samples

Download data: TXT

Series

Accession:: GSE107854

ID:: 200107854

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 1000190572.

Illumina NextSeq 500 (Mus musculus)

Organism:: Mus musculus

10286 Series
295783 Samples

Platform

Accession:: GPL19057

ID:: 100019057

Select item 1000131123.

Illumina HiSeq 2000 (Mus musculus)

Organism:: Mus musculus

8349 Series
188710 Samples

Platform

Accession:: GPL13112

ID:: 100013112

Select item 3028818574.

Ter119pos_PRMT5_WT_B

Organism:: Mus musculus

Source name:: E14.5 Fetal Liver Cells

Platform:: GPL19057
Series:: GSE107854

Sample

Accession:: GSM2881857

ID:: 302881857

SRA Run Selector

Select item 3028818565.

Ter119pos_PRMT5_WT_A

Organism:: Mus musculus

Source name:: E14.5 Fetal Liver Cells

Platform:: GPL19057
Series:: GSE107854

Sample

Accession:: GSM2881856

ID:: 302881856

SRA Run Selector

Select item 3028818556.

Ter119pos_PRMT5_KO_B

Organism:: Mus musculus

Source name:: E14.5 Fetal Liver Cells

Platform:: GPL19057
Series:: GSE107854

Sample

Accession:: GSM2881855

ID:: 302881855

SRA Run Selector

Select item 3028818547.

Ter119pos_PRMT5_KO_A

Organism:: Mus musculus

Source name:: E14.5 Fetal Liver Cells

Platform:: GPL19057
Series:: GSE107854

Sample

Accession:: GSM2881854

ID:: 302881854

SRA Run Selector

Select item 3028818538.

Ter119neg_PRMT5_WT_B

Organism:: Mus musculus

Source name:: E14.5 Fetal Liver Cells

Platform:: GPL19057
Series:: GSE107854

Sample

Accession:: GSM2881853

ID:: 302881853

SRA Run Selector

Select item 3028818529.

Ter119neg_PRMT5_WT_A

Organism:: Mus musculus

Source name:: E14.5 Fetal Liver Cells

Platform:: GPL19057
Series:: GSE107854

Sample

Accession:: GSM2881852

ID:: 302881852

SRA Run Selector

Select item 30288185110.

Ter119neg_PRMT5_KO_B

Organism:: Mus musculus

Source name:: E14.5 Fetal Liver Cells

Platform:: GPL19057
Series:: GSE107854

Sample

Accession:: GSM2881851

ID:: 302881851

SRA Run Selector

Select item 30288185011.

Ter119neg_PRMT5_KO_A

Organism:: Mus musculus

Source name:: E14.5 Fetal Liver Cells

Platform:: GPL19057
Series:: GSE107854

Sample

Accession:: GSM2881850

ID:: 302881850

SRA Run Selector

Select item 30289408212.

Organism:: Mus musculus

Source name:: sorted LK cells from Mx1-cre;PRMT5fl/fl (KO)

Platform:: GPL13112
Series:: GSE107854

Sample

Accession:: GSM2894082

ID:: 302894082

SRA Run Selector

Select item 30289408113.

Organism:: Mus musculus

Source name:: sorted LK cells from Mx1-cre;PRMT5fl/fl (KO)

Platform:: GPL13112
Series:: GSE107854

Sample

Accession:: GSM2894081

ID:: 302894081

SRA Run Selector

Select item 30289408014.

Organism:: Mus musculus

Source name:: sorted LK cells from Mx1-cre;PRMT5fl/fl (KO)

Platform:: GPL13112
Series:: GSE107854

Sample

Accession:: GSM2894080

ID:: 302894080

SRA Run Selector

Select item 30289407915.

Organism:: Mus musculus

Source name:: sorted LK cells from PRMT5fl/fl (WT)

Platform:: GPL13112
Series:: GSE107854

Sample

Accession:: GSM2894079

ID:: 302894079

SRA Run Selector

Select item 30289407816.

Organism:: Mus musculus

Source name:: sorted LK cells from PRMT5fl/fl (WT)

Platform:: GPL13112
Series:: GSE107854

Sample

Accession:: GSM2894078

ID:: 302894078

SRA Run Selector

Select item 30289407717.

Organism:: Mus musculus

Source name:: sorted LK cells from PRMT5fl/fl (WT)

Platform:: GPL13112
Series:: GSE107854

Sample

Accession:: GSM2894077

ID:: 302894077

SRA Run Selector

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GSE107854[Accession] (17)
GEO DataSets
Saccharomyces cerevisiae S288C DNA repair protein RAD14 (RAD14), partial mRNA
Saccharomyces cerevisiae S288C DNA repair protein RAD14 (RAD14), partial mRNA
gi|296147320|ref|NM_001182708.1|

Nucleotide
uncharacterized protein Dere_GG26506, isoform B [Drosophila erecta]
uncharacterized protein Dere_GG26506, isoform B [Drosophila erecta]
gi|945212764|gb|KQS71089.1||gnl|WGS |GG26506-PB

Protein
Stelis lilliputana (0)
PopSet
Macaranga grandifolia internal transcribed spacer 1, partial sequence; 5.8S ribo...
Macaranga grandifolia internal transcribed spacer 1, partial sequence; 5.8S ribosomal RNA gene and internal transcribed spacer 2, complete sequence; and 28S ribosomal RNA gene, partial sequence
gi|114704123|gb|DQ866554.1|

Nucleotide

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