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Items: 1 to 20 of 602

1.
Full record GDS5826

Multiple myeloma cell lines with acquired resistance to chemotherapeutic agent carfilzomib

Analysis of proteasome inhibitor carfilzomib-resistant multiple myeloma (MM) cell lines KMS-11/Cfz and KMS-34/Cfz, after 1 week of growth in the absence of carfilzomib. Results provide insight into the molecular mechanisms underlying the acquisition of proteasome inhibitor resistance in MM.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 4 cell line, 2 cell type sets
Platform:
GPL570
Series:
GSE69078
12 Samples
Download data: CEL
DataSet
Accession:
GDS5826
ID:
5826

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

2.
Full record GDS5913

SRPIN803 small molecule inhibitor of SRPK1 effect on retinal pigment epithelial cell line

Analysis of retinal pigment epithelial ARPE-19 cells treated with SRPIN803, a small molecule inhibitor of serine-arginine protein kinase 1 SRPK1. SRPK1 inhibition prevents pathological angiogenesis. Results provide insight into the molecular mechanisms underlying the inhibitory activity of SRPIN803.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent sets
Platform:
GPL570
Series:
GSE62947
6 Samples
Download data: CEL
DataSet
Accession:
GDS5913
ID:
5913

PubMed Similar studies GEO Profiles Analyze DataSet

3.
Full record GDS6083

Chronic lymphocytic leukemia cells response to the neutralization of inhibitor of apoptosis proteins

Analysis of chronic lymphocytic leukemia (CLL) cells treated with BV6, a Smac mimetic. CLL is characterized by B-lymphocyte accumulation, which is attributed to defective cell death. Inhibitor of apoptosis (IAP) proteins are highly expressed in CLL cells. Smac binds to and inhibits IAP proteins.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 4 genotype/variation, 4 individual, 2 other, 2 time sets
Platform:
GPL570
Series:
GSE62533
12 Samples
Download data: CEL
DataSet
Accession:
GDS6083
ID:
6083

PubMed Similar studies GEO Profiles Analyze DataSet

4.
Full record GDS5817

Interleukin 17A effect on monocyte-derived dendritic cells

Analysis of in vitro-generated dendritic cells (DCs) cultured with interleukin 17A (IL-17A) in the absence or presence of interferon-γ. IL-17A is involved in chronic inflammatory diseases. Results provide insight into the impact of IL-17A on DCs and the role of these DCs in inflammatory disease.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 protocol, 2 time sets
Platform:
GPL570
Series:
GSE53163
9 Samples
Download data: CEL
DataSet
Accession:
GDS5817
ID:
5817

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

5.
Full record GDS5614

All-trans retinoic acid effect on HL60 myeloid cells overexpressing ecotropic virus integration site 1

Analysis of EVI1-overexpressing HL60 myeloid cells treated with ATRA. EVI1 overexpression is associated with poor prognosis in myeloid leukemias; ATRA is a myeloid differentiation inducing agent. Results provide insight into the potential interplay between EVI1 and ATRA in myeloid cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets
Platform:
GPL570
Series:
GSE66837
12 Samples
Download data: CEL
DataSet
Accession:
GDS5614
ID:
5614

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

6.
Full record GDS5613

All-trans retinoic acid effect on U937 myeloid cells overexpressing ecotropic virus integration site 1

Analysis of EVI1-overexpressing U937 myeloid cells treated with ATRA. EVI1 overexpression is associated with poor prognosis in myeloid leukemias; ATRA is a myeloid differentiation inducing agent. Results provide insight into the potential interplay between EVI1 and ATRA in myeloid cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets
Platform:
GPL570
Series:
GSE66854
12 Samples
Download data: CEL
DataSet
Accession:
GDS5613
ID:
5613

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7.
Full record GDS5804

PI3K/mTOR Inhibitor NVP-BEZ235 and taxotere effects on prostate cancer xenograft tumors

Analysis of DU145 xenograft tumors in NOD/SCID mice treated with NVP-BEZ235, taxotere, or both. NVP-BEZ235 targets prostate cancer progenitor cells. Taxotere targets the bulk tumor. Results provide insight into potential biomarkers associated with cancer stem cells in these xenograft tumors.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 agent sets
Platform:
GPL570
Series:
GSE49232
4 Samples
Download data: CEL
DataSet
Accession:
GDS5804
ID:
5804

PubMed Similar studies GEO Profiles Analyze DataSet

8.
Full record GDS5443

Human and chimpanzee TS12KOS vector-generated induced pluripotent stem cells

Analysis of chimpanzee iPSCs generated from blood cells using Sendai virus vector TS12KOS which carries reprogramming factors KLF4, OCT3/4, and SOX2. TS12KOS was also used to establish human iPSCs from fibroblasts. Results examine differentially expressed genes between human and chimpanzee iPSCs.
Organism:
Pan troglodytes; Homo sapiens
Type:
Expression profiling by array, transformed count, 2 cell type, 5 individual, 2 species sets
Platform:
GPL570
Series:
GSE62572
7 Samples
Download data: CEL
DataSet
Accession:
GDS5443
ID:
5443

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

9.
Full record GDS5430

Ethanol effect on lymphoblastoid cell lines from alcoholics

Analysis of lymphoblastoid cell lines (LCLs), obtained from alcoholics, after treatment with ethanol in vitro. Results provide insight into the feasibility of using LCLs to study the molecular consequences of exposure to alcohol.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 disease state, 2 gender, 42 individual sets
Platform:
GPL570
Series:
GSE52553
84 Samples
Download data: CEL, CHP
DataSet
Accession:
GDS5430
ID:
5430

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

10.
Full record GDS5426

Hutchinson Gilford Progeria Syndrome cell line response to oncogenic challenge

Analysis of skin fibroblasts from Hutchinson Gilford Progeria Syndrome (HGPS) patients challenged by retroviral introduction of telomerase reverse transcriptase (TERT), V12-HRAS and SV40 large and small T antigens. Results provide insight into molecular basis of transformation resistance in HGPS.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state, 4 individual, 2 protocol sets
Platform:
GPL570
Series:
GSE60518
8 Samples
Download data: CEL
DataSet
Accession:
GDS5426
ID:
5426

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

11.
Full record GDS5607

A 3-D ex vivo model of oral wound healing: primary gingival fibroblasts

Analysis of gingival fibroblasts populating sponge-type or gel-type collagen scaffolds loaded with platelet-derived growth factor-BB. Collagen scaffolds augment oral soft tissue to support wound repair. Results provide insight into molecular basis of cell population dynamics of collagen scaffolds.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 growth protocol sets
Platform:
GPL570
Series:
GSE61314
4 Samples
Download data: CEL, CHP
DataSet
Accession:
GDS5607
ID:
5607

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

12.
Full record GDS5275

Oral ruxolinitib effect on alopecia areata patients: scalp skin

Analysis of scalp skin from two alopecia areata (AA) patients treated with oral ruxolitinib for 12 weeks. AA is a T-cell mediated autoimmune disease. Ruxolitinib is a small-molecule inhibitor of the JAK1/2 kinases. Results provide insight into molecular mechanisms underlying the pathogenesis of AA.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 disease state, 5 individual, 2 time sets
Platform:
GPL570
Series:
GSE58573
7 Samples
Download data: CEL
DataSet
Accession:
GDS5275
ID:
5275

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

13.
Full record GDS5272

Alopecia areata: scalp skin

Analysis of scalp skin from patients with alopecia areata (AA). AA is a common autoimmune disease resulting from damage of the hair follicle by T cells. Results provide insight into the molecular mechanisms underlying AA pathogenesis.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state sets
Platform:
GPL570
Series:
GSE45512
10 Samples
Download data: CEL
DataSet
Accession:
GDS5272
ID:
5272

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

14.
Full record GDS5324

Beta-catenin depletion effect on pancreatic cancer cell line

Analysis of AsPc1 pancreatic adenocarcinoma cells depleted for beta-catenin. Dysregulation of Wnt/β-catenin signaling is implicated in the pathogenesis of cancers. Results compared to those from AsPC1 cells treated with the CREB-binding protein inhibitor ICG-001 (GDS5323).
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL570
Series:
GSE57728
4 Samples
Download data: CEL
DataSet
Accession:
GDS5324
ID:
5324

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

15.
Full record GDS5323

CREB-Binding Protein Inhibitor ICG-001 effect on pancreatic cancer cell line: time course

Analysis of AsPC1 pancreatic adenocarcinoma (PDAC) cells treated with IGC-001 up to 24 hours. IGC-001 binds to CREB-binding protein to disrupt its interaction with β-catenin. Results compared to β-catenin depletion (GDS5324) and provide insight into the therapeutic potential of IGC-001 in PDAC.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 time sets
Platform:
GPL570
Series:
GSE57728
12 Samples
Download data: CEL
DataSet
Accession:
GDS5323
ID:
5323

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

16.
Full record GDS5211

Turner syndrome: second trimester amniotic fluid

Analysis of second trimester amniotic fluid from Turner syndrome and euploid female fetuses. Turner syndrome is a sex chromosome aneuploidy generally due to monosomy X. Results provide insight into molecular mechanisms underlying Turner syndrome pathogenesis.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state, 2 genotype/variation sets
Platform:
GPL570
Series:
GSE58435
10 Samples
Download data: CEL
DataSet
Accession:
GDS5211
ID:
5211

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

17.
Full record GDS5298

miR-28 expression effect on Burkitt lymphoma cell line: time course

Analysis of P3HR1 Burkitt lymphoma (BL) cells expressing miR-28 for 12 and 24 hours. BL is a highly aggressive B-cell non-Hodgkin lymphoma. miR-28 is downregulated in BL. Results provide insight into the role of miR-28 in the pathogenesis of BL.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 protocol, 2 time sets
Platform:
GPL570
Series:
GSE56268
24 Samples
Download data: CEL, CHP
DataSet
Accession:
GDS5298
ID:
5298

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18.
Full record GDS4951

Lysophosphatidic acid effect on breast and prostate cancer cell lines

Analysis of MDA-MB-231, MCF7 and PC3 cells treated with lysophosphatidic acid (LPA). LPA activates six different G protein-coupled receptors (LPA receptors 1-6). Results provide insight into LPA-induced genes among three unrelated cancer cell lines expressing different patterns of LPA receptors.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 3 cell line sets
Platform:
GPL570
Series:
GSE56265
12 Samples
Download data: CEL, CHP
DataSet
Accession:
GDS4951
ID:
4951

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19.
Full record GDS4994

IFNβ-1a in vivo treatment effect on CIS multiple sclerosis patients: peripheral blood mononuclear cells

Analysis of PBMCs from patients with clinically isolated syndrome suggestive of multiple sclerosis (CIS) after 12 months of IFNβ-1a treatment. All patients exhibited a favorable response to IFN-β-1a treatment. Results provide insight into the role of endogenous IFN-β in the pathogenesis of MS.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 6 individual, 2 protocol sets
Platform:
GPL570
Series:
GSE53716
12 Samples
Download data: CEL
DataSet
Accession:
GDS4994
ID:
4994

PubMed Similar studies GEO Profiles Analyze DataSet

20.
Full record GDS5059

Acute myeloid leukemia fusion oncogenes in vitro effect on primary CD34+ cells: time course

Analysis of CD34+ cells nucleofected (6h) or transduced (3d, 8d) with AML leukemia fusion oncogenes: AML1-ETO, MLL-AF9, PML-RARA or NUP98-HOXA9. Results provide insight into molecular mechanisms of fusion oncogene-driven leukemogenesis and early temporal patterns of gene deregulation in AML.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 10 protocol, 3 time sets
Platform:
GPL570
Series:
GSE57194
30 Samples
Download data: CEL
DataSet
Accession:
GDS5059
ID:
5059

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

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  • Homologene neighbors for GEO Profiles (Select 125639158) (0)
    GEO Profiles
  • dickkopf-related protein 3 isoform 2 precursor [Homo sapiens]
    dickkopf-related protein 3 isoform 2 precursor [Homo sapiens]
    gi|1057503110|ref|NP_001317149.1|
    Protein

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