Hutchinson Gilford Progeria Syndrome cell line response to oncogenic challenge
Summary:
Analysis of skin fibroblasts from Hutchinson Gilford Progeria Syndrome (HGPS) patients challenged by retroviral introduction of telomerase reverse transcriptase (TERT), V12-HRAS and SV40 large and small T antigens. Results provide insight into molecular basis of transformation resistance in HGPS.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Fernandez P, Scaffidi P, Markert E, Lee JH et al. Transformation resistance in a premature aging disorder identifies a tumor-protective function of BRD4. Cell Rep 2014 Oct 9;9(1):248-260. PMID: 25284786
