3-Bromo-4-hydrazinylpyridine - GEO DataSets

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The following terms were not found in GEO DataSets: hydrazinylpyridine, 3-Bromo-4-hydrazinylpyridine.
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Select item 2002464971.

Spatial targeting of the prostaglandin receptor EP2 is essential in driving a sustained PGE2-mediated cAMP signaling in the human endometrium

(Submitter supplied) In a process known as decidualization, progesterone signaling in the human endometrium converges with local cAMP production to drive morphometric and transcriptomic changes that prepare the endometrium for pregnancy. The source of cAMP has been contentious but the prostaglandin PGE2 signaling through EP2, its G-protein coupled receptor, remains a strong candidate. Cells often employ additional receptor regulation to diversify and prolong the cAMP signal and its down-steam effects, most notably through internalization and trafficking of receptors through endosomes. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
21 Samples

Download data: TXT

Series

Accession:: GSE246497

ID:: 200246497

Select item 2002739712.

Carfilzomib Suppresses SENP1 to Trigger Cardiotoxicity by DDX17 Destabilization

(Submitter supplied) Carfilzomib has a good effect in treating multiple myeloma, but more and more clinical studies have shown that the drug can cause cardiac toxicity during use, but the mechanism of action is unclear. This study aimed to comprehensively elucidate the mechanism of CFZ-induced cardiomyopathy by constructing a C57BL/6 mouse model and combining cell experiments. The research results showed that the hearts of mice treated with CFZ appeared significantly enlarged, and the cardiac function indicators decreased. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30103
4 Samples

Download data: TXT

Series

Accession:: GSE273971

ID:: 200273971

Select item 2002697223.

Scar matrix drives Piezo1 mediated stromal inflammation leading to placenta accreta spectrum

(Submitter supplied) Scar tissue formation is a hallmark of wound repair in adults and can chronically affect tissue architecture and function. To understand the general phenomena, we sought to explore scar-driven imbalance in tissue homeostasis caused by a common, and standardized surgical procedure, the uterine scar due to cesarean surgery. Deep uterine scar is associated with a rapidly increasing condition in pregnant women, placenta accreta spectrum (PAS), characterized by aggressive trophoblast invasion into the uterus, frequently necessitating hysterectomy at parturition. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15433
9 Samples

Download data: XLSX

Series

Accession:: GSE269722

ID:: 200269722

Analyze with GEO2R

Select item 2002431574.

Impaired bone morphogenetic protein signaling pathways perturb decidualization in patients with endometriosis (SMAD1/5 siRNA studies)

(Submitter supplied) It is hypothesized that impaired endometrial decidualization contributes to decreased fertility in endometriosis patients. To identify the molecular defects that underpin defective decidualization in endometriosis, we subjected endometrial stromal cells from healthy individuals or with endometriosis to time course in vitro decidualization with estradiol, progesterone, and 8-bromo-cyclic-AMP (EPC) for 2, 4, 6, or 8 days. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
12 Samples

Download data: CSV

Series

Accession:: GSE243157

ID:: 200243157

Analyze with GEO2R

Select item 2002365985.

BET bromodomain Inhibition Potentiates Radiosensitivity by Reprograming DNA Damage Repair in H3K27M-Mutant Glioma

(Submitter supplied) Diffuse intrinsic pontine glioma (DIPG) is one of the devastating childhood cancers. Radiation therapy remains the only effective treatment yet provides a 5-year survival rate of only1%. Several clinical trials have attempted to enhance radiation anti-tumor activity using radiosensitizing agents, though none have been successful in doing so. Given this, there is a critical need for identifying effective therapeutics to enhance radiation sensitivity for the treatment of DIPG. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL18573 GPL24676
17 Samples

Download data: BIGWIG, CSV

Series

Accession:: GSE236598

ID:: 200236598

Analyze with GEO2R

Select item 2002266706.

The alternative Nucleosome Remodeling Factor complex sustains acute myeloid leukemia by regulating the accessibility of insulator regions (ATAC-seq)

(Submitter supplied) Efficient treatment of Acute Myeloid Leukemia (AML) patients remains a challenge despite recent advances. Here using a CRISPRi screen targeting chromatin factors, we identified BPTF as an essential regulator of AML cell survival. We demonstrate that BPTF forms an alternative NURF chromatin remodeling complex with SMARCA5 and BAP18, which regulates the accessibility of a large set of insulator regions in leukemic cells. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL21697 GPL30173
14 Samples

Download data: BW, TXT, XLSX

Series

Accession:: GSE226670

ID:: 200226670

PubMed Full text in PMC Similar studies

Select item 2002266877.

The alternative Nucleosome Remodeling Factor complex sustains acute myeloid leukemia by regulating the accessibility of insulator regions (RNA-seq)

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
9 Samples

Download data: TXT, XLSX

Series

Accession:: GSE226687

ID:: 200226687

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002266718.

The alternative Nucleosome Remodeling Factor complex sustains acute myeloid leukemia by regulating the accessibility of insulator regions (Cut&Run)

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL21697 GPL30173
31 Samples

Download data: BIGWIG, BW, XLSX

Series

Accession:: GSE226671

ID:: 200226671

PubMed Full text in PMC Similar studies

Select item 2001602329.

hPSC-derived Airway Organoids-based Screen Reveals the Role of HIF1/Glycolysis Axis in SARS-CoV-2 Infection.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
16 Samples

Download data: MTX, TSV

Series

Accession:: GSE160232

ID:: 200160232

Select item 20016023010.

hPSC-derived Airway Organoids-based Screen Reveals the Role of HIF1/Glycolysis Axis in SARS-CoV-2 Infection [bulk RNA-seq]

(Submitter supplied) SARS-CoV-2, the virus causing recently pandemic, primarily infects the respiratory tract. There is an urgent need to develop platforms using disease relevant human cells to dissect the molecular mechanism regulating SARS-CoV-2 infection and perform drug screen. Here, we derived airway organoids from human pluripotent stem cells (hPSC-AO). The hPSC-AOs, particularly ciliated cells, express ACE2 and are permissive to SARS-CoV-2 infection. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
15 Samples

Download data: TXT

Series

Accession:: GSE160230

ID:: 200160230

Analyze with GEO2R SRA Run Selector

Select item 20022739211.

PHDs-seq: A Large-scale Phenotypic Screening Method for Drug Discovery through Parallel Multi-readout Quantification

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20795
146 Samples

Download data

Series

Accession:: GSE227392

ID:: 200227392

PubMed Full text in PMC Similar studies

Select item 20022739112.

PHDs-seq: A Large-scale Phenotypic Screening Method for Drug Discovery through Parallel Multi-readout Quantification [Targeted RNA-seq: KF-b3_0723]

(Submitter supplied) High-throughput phenotypic screening is a cornerstone of drug development and the main technical approach for stem cell research. However, simultaneous detection of activated core factors responsible for cell fate determination and accurate assessment of directional cell transition are difficult using conventional screening methods that focus on changes in only a few biomarkers. The PHDs-seq (Probe Hybridization based Drug screening by sequencing) platform was developed to evaluate compound function based on their transcriptional effects in a wide range of signature biomarkers. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20795
131 Samples

Download data: CSV

Series

Accession:: GSE227391

ID:: 200227391

PubMed Full text in PMC Similar studies

Select item 20021709913.

Evaluation of broad anti-coronavirus activity of autophagy-related compounds using human airway organoids

(Submitter supplied) To deal with the broad spectrum of coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), that threatens human health, it is essential to develop not only drugs that target viral proteins but also consider drugs that target host proteins/cellular processes to protect them from being hijacked for viral infection and replication. To this end, it has been reported that autophagy is deeply involved in coronavirus infection. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21697
12 Samples

Download data: TXT

Series

Accession:: GSE217099

ID:: 200217099

Select item 20020320714.

Mitigating reprogramming stress with dominant negative BET deletion fragments

(Submitter supplied) The iPSC reprogramming is very inefficient and has an early stochastic stage. The cause of the low efficiency and stochastic nature are poorly understood. The bromo- and extra-terminal domain (BET) proteins have impacts on cellular reprogramming, but the molecular mechanisms are elusive. Here we show that the reprogramming factors cause dramatic reprogramming stresses including massive transcriptional turbulence, massive and random dysregulation of stress response genes, cell cycle impairment, and cytotoxicity. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL29480 GPL16791
54 Samples

Download data: XLSX

Series

Accession:: GSE203207

ID:: 200203207

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013123115.

Next Generation Sequencing (NGS) Facilitates Quantitative Analysis of Non-silencing Control and EP300 Knockdown Transcriptomes

(Submitter supplied) Purpose: The goal of this study is to identify p300-regulated genes.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
4 Samples

Download data: TXT

Series

Accession:: GSE131231

ID:: 200131231

Analyze with GEO2R SRA Run Selector

Select item 20016299616.

scRNA profiles on hESC-derived lung cells and lung-macrophage co-cultured cells

(Submitter supplied) We established a co-culture model using cells derived from hPSC and studied the transcriptomes on the lung cells and the co-cultures using scRNA-seq.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
3 Samples

Download data: MTX, TSV

Series

Accession:: GSE162996

ID:: 200162996

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016856417.

NanoString PanCancer Immune Profiling of 4′‐bromo‐resveratrol treated BrafV600E/PtenNULL melanoma mice

(Submitter supplied) We performed differential gene expression analysis using high throughput multiplex analysis via NanoString nCounter PanCancer Immune Profiling panel, which analyzes 770 genes related to cancer-immune pathways (cancer progression, chemokines and cytokines and their receptors, and innate and adaptive immune response). nSolver software was used to analyze the data and a heat map was generated to show differential expression of 770 genes. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL22364
6 Samples

Download data: TXT, XLSX

Series

Accession:: GSE168564

ID:: 200168564

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007562418.

Multivalent histone and DNA engagement by the triple reader module of ZMYND8 directs the recruitment of a transcriptional network to genes to regulate gene expression

(Submitter supplied) Elucidation of multivalent interactions involving both DNA and histone post-translational-modifications (PTMs) is essential for providing insight into complex biological functions. We report here the high resolution crystal structure of the N-terminal triple reader module (PHD-Bromo-PWWP) of ZMYND8, which forms a stable unit, capable of simultaneously recognizing histone PTMs and providing a charged platform for DNA interaction. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
15 Samples

Download data: TXT

Series

Accession:: GSE75624

ID:: 200075624

Analyze with GEO2R

Select item 20012806019.

Large-scale Generation of Functional and Transplantable Hepatocytes and Cholangiocytes from Human Endoderm Stem Cells

(Submitter supplied) The ever-increasing therapeutic and pharmaceutical demand for liver cells calls for systems that enable mass production of hepatic cells. Here we describe a large-scale suspension system that uses human endoderm stem cells (hEnSCs) as precursors to generate functional and transplantable hepatocytes (E-heps) or cholangiocytes (E-chos). hEnSC-derived hepatic populations are characterized by single-cell transcriptomic analyses and compared with hESC-derived counterparts, in-vitro-maintained or -expanded primary hepatocytes and adult cells, which reveals that hepatic differentiation of hEnSCs recapitulates in vivo development and that the heterogeneities of the resultant populations can be manipulated by regulating the EGF and MAPK signaling pathways. more...