2IPF,1AFS,1IHI,1J96,1LWI,1MRQ,1Q13,1Q5M,1RAL,1RY0,1S1P,1XJB,2FVL,2HE5,5HNU,2IPG,2IPJ,3C3U,3CV6,3FJN,3GUG,3LN3,3R43,3UWE,4DZ5,4JQ1,4L1X,4YVV,5JM5,5UXF,6F2U,6F78


Conserved Protein Domain Family
AKR_AKR1C1-35
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cd19108: AKR_AKR1C1-35 
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AKR1C family of aldo-keto reductase (AKR)
The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.
Links
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Statistics
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PSSM-Id: 381334
Aligned: 118 rows
Threshold Bit Score: 590.741
Created: 9-Mar-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic
Conserved site includes 38 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2IPF: Mus musculus 17alpha-hydroxysteroid dehydrogenase (AKR1C21) in complex with cofactor NADP+ and epi-testosterone, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                        ###                         #   ##                            # 
2IPF_A         1 HCVILNDGNfIPVLGFGTALPLEcPKSKAKELTKIAIDAGFHHFDSASVYnTEDHVGEAIRSKIADGtvRREDIFYTSKV 80  house mouse
2008147B       6 RSVKLNDPHlMPVLGFGTFASKEiPKSKAAEATKVAIDVGFRHIDAAYFYqNEEEVGQALRDKMADGtvKREDLFYTTKI 85  Norway rat
P02532         7 TRVTLNDGNmMPILGLGTYASPHvPKSLAEEAVKIAIDVGYRHIDCAFITgNEMHIGNGIRSKISDGtvKREDIFYTGKL 86  common frog
P17264         7 TRVTLNDGNmMPILGLGTYAAPDvPKSLAEEAVKTAIDVGYRHIDCAFITgNEMHIGNGIRSKISDGtvKREDIFYTGKL 86  American bullfrog
NP_001012344   7 RSVKLNDGLsMPPLGFGTSAPSKvPKTEVEEAVKRAIDVGYRHFDSAYMYlNEEEIGRAIQRKIADGtvKREDIFYTSKV 86  dog
NP_001038083   8 FSLKMNDGHtIPMLGLGTSAPSQvLKSETEMAIKRAIDIGYRHIDSAHLYqNEEEIGRAIQMKIADGtvKRDDIFHTTKV 87  pig
NP_001039264   7 SCVELSDGHkMPVLGFGTYAPQKsPKHLAEEGTKVAIDVGYRHIDCAFIYgNEVEVGRAIGAKIADGtvKREDVFYTGKL 86  western clawed ...
EAW86451       9 HSVRLNDGPfMPVLGFGTYAPDHtPKSQAAEATKVAIDVGFRHIDSAYLYqNEEEVGQAIWEKIADGtvKREEIFYTIKL 88  human
XP_018426641   7 PTLLMNDGNkIPVIGFGTYAPEYiPVSLSEEATEVAIEVGYRHIDGAHLYqNEKEVGRAIQKKIADGtvKREDLFYTGKL 86  Nanorana parkeri
PIO35006       7 TRLPLNDGNtIPILGLGTYASPDvPKSTGEEATKVAIELGYRHIDCAYIYgNEVQIGSAIRAKIADGtvKREDIFYTGKL 86  bullfrog

Feature 1        #                              ## #        ##                                   
2IPF_A        81 WCtslhPELVRASLERSLQKLQfDYVDLYLIHYPMa-lKPGEENFPVDEHGKLIfdRVDLCATWEAMEKCKDAGLTKSIG 159 house mouse
2008147B      86 WItflrPELVRQCLERSLKKLGlDYVDLCIIHIPIa-mKPGEELLPKPANGKFIfdTVDIRDTWEALEKCKDAGLSKSIG 164 Norway rat
P02532        87 WCtyfsPEMVRKGLERSLRDVGmDYLDLFLMHWPVs-lKPSGASDPSDKDKPFIydNVDLCATWEALEARKDAGLVRSLG 165 common frog
P17264        87 WCtyfsPDMVRKGLERSLRDVGmDYLDLFLMHWPVs-lKPSGASDPSDKDKPFIydNVDLCATWEALEARKDAGLVRSLG 165 American bullfrog
NP_001012344  87 WVtflrPELVQTNLEMSLKKLGfSYVDLYLIHFPVp-lKPGEELFPKDKDGKIIfdRVDLCATWEAMEKCKDSGLAKSIG 165 dog
NP_001038083  88 WGtffrPELVQTNLERSLKKLQmSYVDLYLLHHPEa-lQAGEDFFPKDTHGNIIfdTVDLCTTWEAMEKCKNEGLTRSIG 166 pig
NP_001039264  87 WSsfhtPERVRVCLEKSLKDLQlDYMDLFIIHNPMe-fKPGDDPLPLDENGKLIyhNTDIRDTWKALEKCKDAGLVRSIG 165 western clawed ...
EAW86451      89 WAtffrAELVHPALERSLKKLGpDYVDLFIIHVPFa-mKPGKELLPKDASGEIIleTVELCDTWEALEKCKEAGLTRSIG 167 human
XP_018426641  87 WStfhsPELVEPNVKHSLETLQlDYMDLFLIHWPFslkPGGDLIPMDENGKPQLdtTTDLCALWEAIEKCKDAGLVKSIG 166 Nanorana parkeri
PIO35006      87 WPtffsPDLVRKGLEKSLSDVGlEYLDLFIMHWPFs-lKHEGAEKPANSDKPFAydDVDFCSTWEALEACKDAGLVKSIG 165 bullfrog

Feature 1         ##                      #                         ####### #  #        #        
2IPF_A       160 VSNFNYRQLEMILNKPGLKyKPVCNQVECHPYlNQMKLLDFCKSKdIVLVAYGVLGTQRYggWVDQNSPVLLDEPVLGSM 239 house mouse
2008147B     165 VSNFNLKQLELILNKPGLKyKPTCNQVECHPYlNQSKLLEFCKSKdIVLVAYSALGSHRDssWVSSDSPYLLEDPVLMTI 244 Norway rat
P02532       166 VSNFNRRQLERILNKPGLKyKPVCNQVECHVYlNQNKLHSYCKSKdIVLVTYSVLGSHRDrnWVDLSLPVLLDDPILNKV 245 common frog
P17264       166 VSNFNRRQLERILNKPGLKyKPVCNQVECHVYlNQNKLHSYCKSKdIVLVTYSVLGSHRDrnWVDLSLPVLLDDPILNKI 245 American bullfrog
NP_001012344 166 VSNFNRRQLERILSKPRLKyKPVCNQVECHLYfNQSKLLEFCKSKdIILTAYGALGSDFGkeWVNQDAPVLLKDPVLNAV 245 dog
NP_001038083 167 VSNFNCKQLERILNKPGLKyKPVCNQVECHPYlNQSKLLEFCRSHdILLVAYATLGSDARkkWVIKNKPSLLQDPVLNAI 246 pig
NP_001039264 166 VSNFNHKQLELILNMPGLKyKPVCNQVECHIYlNQSKLLEFCKSKdIVLVGYSVLGSSRDerWIDQNSPVLLEDPVLNVI 245 western clawed ...
EAW86451     168 VSNFNHKLLELILNKPGLKyKPTCNQVECHPYlNQSKLLEFFKSKdIVLVAYSALGSQRDpqWVDPDCPHLLEEPILKSI 247 human
XP_018426641 167 VSNFNRRQLEKIFNKPGLKyKPVCNQVECQPYlNQSKLLEFCKSHdILLTAYSVLGSHRHkdWVDQNSPVLLEDPLLAKI 246 Nanorana parkeri
PIO35006     166 VSNFNRRQLERLLNKQGLKyKPVCNQVECHIYlGQSKLQAYCKSKdIILVAYSVLGSHRDkdWVDLSLPVLLEDPILGEV 245 bullfrog

Feature 1                #              ######  #  ##                         # #
2IPF_A       240 AKKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQvfefqLSSEDMKVLDGLNRNMRYIPA 303 house mouse
2008147B     245 AKKHNQTPGQVALRYQLQRGVVVLAKSFNEKRIIENFQvfdfeLTPEDMKTIDSLNRNFRYSQM 308 Norway rat
P02532       246 AAKYNRTSAEIAMRFILQKGIVVLAKSFTPARIKQNLGvfefeLKPEDMKSLESLDRNLHYGPF 309 common frog
P17264       246 AAKYNRTSAEVAMRFILQKGIVVLAKSFTPARIKQNLGvfefeLKPEDMKTLESLDRNLHYGPF 309 American bullfrog
NP_001012344 246 AARHGRTPAQVALRFQLQRGVVALAKSFNEKRIRENFQvfdfqLTPEDMETLSSLNKNIRYFSD 309 dog
NP_001038083 247 AEKHRRTPAQVALRYQLQRGVVALAKSFSEQRIKENFQvfefeLTPEDMESLDGLNRNMCYLQD 310 pig
NP_001039264 246 AKKLNRTPAQVAMRYLLQRGVVVLAKSFTPARIQQNFQvfdfqLDAEDMKSLDGLNRHLRYVDT 309 western clawed frog
EAW86451     248 AKKHSRSPGQVALRYQLQRGVVVLAKSFSQERIKENFQifdfeLTPEDMKAIDGLNRNLRYDKL 311 human
XP_018426641 247 GKKYNKTPANIAIRYQIQRGVVAITKSYNPDRIKENFKvfdfeLTPEDMKAIDGLNKNLRYVDI 310 Nanorana parkeri
PIO35006     246 AAKYNRTPAEVAMRFVLQKGIVVLAKSFSTARLKQNLGvfdfeLKPEDMKTLESLDKNLHYGPF 309 bullfrog

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