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    Krba1 KRAB-A domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 77827, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Krba1provided by MGI
    Official Full Name
    KRAB-A domain containing 1provided by MGI
    Primary source
    MGI:MGI:1925077
    See related
    Ensembl:ENSMUSG00000042810 AllianceGenome:MGI:1925077
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A930040G15Rik
    Summary
    Is expressed in several structures, including early conceptus; genitourinary system; and nervous system. Orthologous to human KRBA1 (KRAB-A domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 12.2), adrenal adult (RPKM 11.8) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Krba1 in Genome Data Viewer
    Location:
    6 B2.3; 6 23.36 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48371577..48396789)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48394643..48419855)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 16630 Neighboring gene nuclear encoded tRNA cysteine 19 (anticodon GCA) Neighboring gene retinol dehydrogenase 11 pseudogene Neighboring gene predicted gene, 38803 Neighboring gene predicted gene, 57777 Neighboring gene zinc finger protein 467

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Pilot-Storck F, et al. Mol Cell Proteomics, 2010 Jul. PMID 20368287, Free PMC Article
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    protein KRBA1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347152.1 → NP_001334081.1  protein KRBA1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC153815
      Consensus CDS
      CCDS85037.1
      UniProtKB/TrEMBL
      A0A140T8R3
      Related
      ENSMUSP00000110219.5, ENSMUST00000114572.9

    2. NM_001347153.1 → NP_001334082.1  protein KRBA1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 1. The first difference causes translation initiation at a downstream AUG; the resulting isoform (3) is shorter at the N-terminus and lacks an alternate internal aa compared to isoform 1.
      Source sequence(s)
      AC153815
      Consensus CDS
      CCDS85038.1
      UniProtKB/TrEMBL
      A0A0N4SVV3
      Related
      ENSMUSP00000145256.2, ENSMUST00000203371.3
      Conserved Domains (2) summary
      PTZ00449
      Location:701 → 818
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam15287
      Location:193 → 235
      KRBA1; KRBA1 family repeat

    3. NM_001362144.1 → NP_001349073.1  protein KRBA1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction in the 5' end compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1. Variants 2 and 4 both encode the same isoform (2).
      Source sequence(s)
      AC153815
      Consensus CDS
      CCDS20102.1
      UniProtKB/Swiss-Prot
      E9QNG7, Q69Z85, Q6NXZ1, Q9JJG3
      Related
      ENSMUSP00000076345.6, ENSMUST00000077093.7
      Conserved Domains (2) summary
      pfam15287
      Location:194 → 236
      KRBA1; KRBA1 family repeat
      cl25751
      Location:702 → 819
      DUF4045; Domain of unknown function (DUF4045)

    4. NM_001362145.1 → NP_001349074.1  protein KRBA1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has a longer and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AB041543, AC153815
      Consensus CDS
      CCDS90043.1
      Related
      ENSMUSP00000031815.6, ENSMUST00000031815.12
      Conserved Domains (2) summary
      pfam15287
      Location:249 → 291
      KRBA1; KRBA1 family repeat
      cl25751
      Location:691 → 808
      DUF4045; Domain of unknown function (DUF4045)

    5. NM_133922.3 → NP_598683.3  protein KRBA1 isoform 2

      See identical proteins and their annotated locations for NP_598683.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction in the 5' end compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1. Variants 2 and 4 both encode the same isoform (2).
      Source sequence(s)
      AC153815, AK040525
      Consensus CDS
      CCDS20102.1
      UniProtKB/Swiss-Prot
      E9QNG7, Q69Z85, Q6NXZ1, Q9JJG3
      Related
      ENSMUSP00000110218.3, ENSMUST00000114571.8
      Conserved Domains (2) summary
      pfam15287
      Location:194 → 236
      KRBA1; KRBA1 family repeat
      cl25751
      Location:702 → 819
      DUF4045; Domain of unknown function (DUF4045)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      48371577..48396789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506757.5 → XP_006506820.1  protein KRBA1 isoform X1

      Conserved Domains (2) summary
      PTZ00449
      Location:763 → 880
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam15287
      Location:250 → 292
      KRBA1; KRBA1 family repeat

    2. XM_006506759.5 → XP_006506822.1  protein KRBA1 isoform X3

      Conserved Domains (2) summary
      PTZ00449
      Location:758 → 875
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam15287
      Location:250 → 292
      KRBA1; KRBA1 family repeat

    3. XM_006506766.5 → XP_006506829.1  protein KRBA1 isoform X9

      Conserved Domains (2) summary
      PTZ00449
      Location:697 → 814
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam15287
      Location:250 → 292
      KRBA1; KRBA1 family repeat

    4. XM_006506767.5 → XP_006506830.1  protein KRBA1 isoform X10

      Conserved Domains (2) summary
      PTZ00449
      Location:692 → 809
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam15287
      Location:250 → 292
      KRBA1; KRBA1 family repeat

    5. XM_006506758.5 → XP_006506821.1  protein KRBA1 isoform X2

      Conserved Domains (2) summary
      PTZ00449
      Location:762 → 879
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam15287
      Location:249 → 291
      KRBA1; KRBA1 family repeat

    6. XM_030255674.2 → XP_030111534.1  protein KRBA1 isoform X13

      Conserved Domains (2) summary
      PTZ00449
      Location:257 → 374
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam15287
      Location:48 → 69
      KRBA1; KRBA1 family repeat

    7. XM_006506763.5 → XP_006506826.1  protein KRBA1 isoform X6

      See identical proteins and their annotated locations for XP_006506826.1

      Conserved Domains (2) summary
      PTZ00449
      Location:707 → 824
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam15287
      Location:194 → 236
      KRBA1; KRBA1 family repeat

    8. XM_030255672.2 → XP_030111532.1  protein KRBA1 isoform X11

      Conserved Domains (2) summary
      PTZ00449
      Location:636 → 753
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam15287
      Location:194 → 236
      KRBA1; KRBA1 family repeat

    9. XM_030255671.2 → XP_030111531.1  protein KRBA1 isoform X7

      Conserved Domains (2) summary
      PTZ00449
      Location:706 → 823
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam15287
      Location:193 → 235
      KRBA1; KRBA1 family repeat

    10. XM_006506760.5 → XP_006506823.1  protein KRBA1 isoform X4

      Conserved Domains (3) summary
      PTZ00449
      Location:742 → 859
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam01352
      Location:6 → 47
      KRAB; KRAB box
      pfam15287
      Location:229 → 271
      KRBA1; KRBA1 family repeat

    11. XM_017321832.3 → XP_017177321.1  protein KRBA1 isoform X12

      Conserved Domains (2) summary
      PTZ00449
      Location:395 → 512
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam15287
      Location:61 → 103
      KRBA1; KRBA1 family repeat

    12. XM_036152396.1 → XP_036008289.1  protein KRBA1 isoform X11

      Conserved Domains (2) summary
      PTZ00449
      Location:636 → 753
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam15287
      Location:194 → 236
      KRBA1; KRBA1 family repeat

    13. XM_030255670.2 → XP_030111530.1  protein KRBA1 isoform X5

      Conserved Domains (3) summary
      PTZ00449
      Location:736 → 853
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam01352
      Location:6 → 47
      KRAB; KRAB box
      pfam15287
      Location:228 → 270
      KRBA1; KRBA1 family repeat

    14. XM_006506762.5 → XP_006506825.1  protein KRBA1 isoform X6

      See identical proteins and their annotated locations for XP_006506825.1

      Conserved Domains (2) summary
      PTZ00449
      Location:707 → 824
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam15287
      Location:194 → 236
      KRBA1; KRBA1 family repeat

    15. XM_036152397.1 → XP_036008290.1  protein KRBA1 isoform X13

      Conserved Domains (2) summary
      PTZ00449
      Location:257 → 374
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam15287
      Location:48 → 69
      KRBA1; KRBA1 family repeat

    16. XM_036152395.1 → XP_036008288.1  protein KRBA1 isoform X8

      UniProtKB/TrEMBL
      A0A0N4SVV3
      Conserved Domains (2) summary
      PTZ00449
      Location:701 → 818
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam15287
      Location:193 → 235
      KRBA1; KRBA1 family repeat

    17. XM_036152398.1 → XP_036008291.1  protein KRBA1 isoform X13

      Conserved Domains (2) summary
      PTZ00449
      Location:257 → 374
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam15287
      Location:48 → 69
      KRBA1; KRBA1 family repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NXZ1.2 GenPept UniProtKB/Swiss-Prot:Q6NXZ1

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