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Nasopharyngeal carcinoma, susceptibility to, 3(NPCA3)

MedGen UID:
934696
•Concept ID:
C4310729
•
Finding
Synonym: NPCA3
 
Gene (location): MST1R (3p21.31)
 
Monarch Initiative: MONDO:0014902
OMIM®: 617075

Definition

Nasopharyngeal carcinoma (NPCA) is a malignant tumor that emerges from the epithelium of the nasopharynx. It has a high incidence in southern China, and evidence suggests that there may be a genetic component that underlies familial clustering. Some patients have onset before 20 years of age (summary by Dai et al., 2016) For a general phenotypic description and a discussion of genetic heterogeneity of susceptibility to nasopharyngeal carcinoma, see NPCA1 (607107). [from OMIM]

Clinical features

From HPO
Nasopharyngeal neoplasm
MedGen UID:
6526
•Concept ID:
C0027439
•
Neoplastic Process
A benign or malignant neoplasm affecting the nasopharynx. Representative examples of benign neoplasms include angiofibroma and squamous papilloma. Representative examples of malignant neoplasms include keratinizing squamous cell carcinoma and nonkeratinizing carcinoma.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Host genetic variants, Epstein-Barr virus subtypes, and the risk of nasopharyngeal carcinoma: Assessment of interaction and mediation.
Xu M, Feng R, Liu Z, Zhou X, Chen Y, Cao Y, Valeri L, Li Z, Liu Z, Cao SM, Liu Q, Xie SH, Chang ET, Jia WH, Shen J, Yao Y, Cai YL, Zheng Y, Zhang Z, Huang G, Ernberg I, Tang M, Ye W, Adami HO, Zeng YX, Lin X
Cell Genom 2024 Feb 14;4(2):100474. Epub 2024 Jan 9 doi: 10.1016/j.xgen.2023.100474. PMID: 38359790Free PMC Article
Association of Caspase-8 Genotypes With the Risk for Nasopharyngeal Carcinoma in Taiwan.
Shih LC, Tsai CW, Chang WS, Shen TC, Wang YC, Yang JS, Lin ML, Wang ZH, Bau DT
Anticancer Res 2020 Oct;40(10):5503-5508. doi: 10.21873/anticanres.14562. PMID: 32988873
Current understanding and management of nasopharyngeal carcinoma.
Yoshizaki T, Ito M, Murono S, Wakisaka N, Kondo S, Endo K
Auris Nasus Larynx 2012 Apr;39(2):137-44. Epub 2011 May 17 doi: 10.1016/j.anl.2011.02.012. PMID: 21592702

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

Recent clinical studies

Etiology

Epidemiology of nasopharyngeal carcinoma: current insights and future outlook.
Su ZY, Siak PY, Lwin YY, Cheah SC
Cancer Metastasis Rev 2024 Sep;43(3):919-939. Epub 2024 Mar 2 doi: 10.1007/s10555-024-10176-9. PMID: 38430391
High-throughput identification of regulatory elements and functional assays to uncover susceptibility genes for nasopharyngeal carcinoma.
Wang TM, Xiao RW, He YQ, Zhang WL, Diao H, Tang M, Mai ZM, Xue WQ, Yang DW, Deng CM, Liao Y, Zhou T, Li DH, Wu YX, Chen XY, Zhang J, Li XZ, Zhang PF, Zheng XH, Zhang SD, Hu YZ, Cai Y, Zheng Y, Zhang Z, Zhou Y, Jin G, Bei J, Mai HQ, Sun Y, Ma J, Hu Z, Liu J, Lung ML, Adami HO, Ye W, Lam TH, Shen H, Jia WH
Am J Hum Genet 2023 Jul 6;110(7):1162-1176. Epub 2023 Jun 22 doi: 10.1016/j.ajhg.2023.06.003. PMID: 37352861Free PMC Article
Association of HLA diversity with the risk of 25 cancers in the UK Biobank.
Wang QL, Wang TM, Deng CM, Zhang WL, He YQ, Xue WQ, Liao Y, Yang DW, Zheng MQ, Jia WH
EBioMedicine 2023 Jun;92:104588. Epub 2023 May 4 doi: 10.1016/j.ebiom.2023.104588. PMID: 37148584Free PMC Article
A Phase II Randomized Clinical Trial and Mechanistic Studies Using Improved Probiotics to Prevent Oral Mucositis Induced by Concurrent Radiotherapy and Chemotherapy in Nasopharyngeal Carcinoma.
Xia C, Jiang C, Li W, Wei J, Hong H, Li J, Feng L, Wei H, Xin H, Chen T
Front Immunol 2021;12:618150. Epub 2021 Mar 24 doi: 10.3389/fimmu.2021.618150. PMID: 33841399Free PMC Article
The HLA-DRB1 allele polymorphisms and nasopharyngeal carcinoma.
Yang H, Yu K, Zhang R, Li J, Wei X, Zhang Y, Zhang C, Xiao F, Zhao D, Lin X, Wu H, Yang X
Tumour Biol 2016 Jun;37(6):7119-28. Epub 2016 Apr 8 doi: 10.1007/s13277-016-5051-9. PMID: 27059731

Diagnosis

Diabetes can increase the prevalence of EBV infection and worsen the prognosis of nasopharyngeal carcinoma.
Midorikawa S, Mizukami H, Kudoh K, Takeuchi Y, Sasaki T, Kushibiki H, Wang Z, Itakura Y, Murakami K, Kudo N, Nagaki T, Wakasa T, Nakamura Y, Matsubara A
Pathology 2024 Feb;56(1):65-74. Epub 2023 Nov 21 doi: 10.1016/j.pathol.2023.09.013. PMID: 38071160
A Phase II Randomized Clinical Trial and Mechanistic Studies Using Improved Probiotics to Prevent Oral Mucositis Induced by Concurrent Radiotherapy and Chemotherapy in Nasopharyngeal Carcinoma.
Xia C, Jiang C, Li W, Wei J, Hong H, Li J, Feng L, Wei H, Xin H, Chen T
Front Immunol 2021;12:618150. Epub 2021 Mar 24 doi: 10.3389/fimmu.2021.618150. PMID: 33841399Free PMC Article
Microbial etiology, susceptibility profile of postradiation nasopharyngeal necrosis patients with nasopharyngeal carcinoma.
Wang L, Yang J, Peng SY, Li GQ, Tu ZW
Cancer Radiother 2020 Apr;24(2):93-98. Epub 2020 Feb 11 doi: 10.1016/j.canrad.2019.09.008. PMID: 32057645
Radio-Susceptibility of Nasopharyngeal Carcinoma: Focus on Epstein- Barr Virus, MicroRNAs, Long Non-Coding RNAs and Circular RNAs.
Lei F, Lei T, Huang Y, Yang M, Liao M, Huang W
Curr Mol Pharmacol 2020;13(3):192-205. doi: 10.2174/1874467213666191227104646. PMID: 31880267
Nasopharyngeal carcinoma.
Brennan B
Orphanet J Rare Dis 2006 Jun 26;1:23. doi: 10.1186/1750-1172-1-23. PMID: 16800883Free PMC Article

Therapy

A Phase II Randomized Clinical Trial and Mechanistic Studies Using Improved Probiotics to Prevent Oral Mucositis Induced by Concurrent Radiotherapy and Chemotherapy in Nasopharyngeal Carcinoma.
Xia C, Jiang C, Li W, Wei J, Hong H, Li J, Feng L, Wei H, Xin H, Chen T
Front Immunol 2021;12:618150. Epub 2021 Mar 24 doi: 10.3389/fimmu.2021.618150. PMID: 33841399Free PMC Article
Microbial etiology, susceptibility profile of postradiation nasopharyngeal necrosis patients with nasopharyngeal carcinoma.
Wang L, Yang J, Peng SY, Li GQ, Tu ZW
Cancer Radiother 2020 Apr;24(2):93-98. Epub 2020 Feb 11 doi: 10.1016/j.canrad.2019.09.008. PMID: 32057645
Association of ERCC1 polymorphisms and susceptibility to nasopharyngeal carcinoma.
Yang ZH, Dai Q, Kong XL, Yang WL, Zhang L
Mol Carcinog 2009 Mar;48(3):196-201. doi: 10.1002/mc.20468. PMID: 18615480
Nasopharyngeal carcinoma.
Brennan B
Orphanet J Rare Dis 2006 Jun 26;1:23. doi: 10.1186/1750-1172-1-23. PMID: 16800883Free PMC Article
Review of nasopharyngeal carcinoma.
Jeyakumar A, Brickman TM, Jeyakumar A, Doerr T
Ear Nose Throat J 2006 Mar;85(3):168-70, 172-3, 184. PMID: 16615599

Prognosis

Epidemiology of nasopharyngeal carcinoma: current insights and future outlook.
Su ZY, Siak PY, Lwin YY, Cheah SC
Cancer Metastasis Rev 2024 Sep;43(3):919-939. Epub 2024 Mar 2 doi: 10.1007/s10555-024-10176-9. PMID: 38430391
Diabetes can increase the prevalence of EBV infection and worsen the prognosis of nasopharyngeal carcinoma.
Midorikawa S, Mizukami H, Kudoh K, Takeuchi Y, Sasaki T, Kushibiki H, Wang Z, Itakura Y, Murakami K, Kudo N, Nagaki T, Wakasa T, Nakamura Y, Matsubara A
Pathology 2024 Feb;56(1):65-74. Epub 2023 Nov 21 doi: 10.1016/j.pathol.2023.09.013. PMID: 38071160
High-throughput identification of regulatory elements and functional assays to uncover susceptibility genes for nasopharyngeal carcinoma.
Wang TM, Xiao RW, He YQ, Zhang WL, Diao H, Tang M, Mai ZM, Xue WQ, Yang DW, Deng CM, Liao Y, Zhou T, Li DH, Wu YX, Chen XY, Zhang J, Li XZ, Zhang PF, Zheng XH, Zhang SD, Hu YZ, Cai Y, Zheng Y, Zhang Z, Zhou Y, Jin G, Bei J, Mai HQ, Sun Y, Ma J, Hu Z, Liu J, Lung ML, Adami HO, Ye W, Lam TH, Shen H, Jia WH
Am J Hum Genet 2023 Jul 6;110(7):1162-1176. Epub 2023 Jun 22 doi: 10.1016/j.ajhg.2023.06.003. PMID: 37352861Free PMC Article
Microbial etiology, susceptibility profile of postradiation nasopharyngeal necrosis patients with nasopharyngeal carcinoma.
Wang L, Yang J, Peng SY, Li GQ, Tu ZW
Cancer Radiother 2020 Apr;24(2):93-98. Epub 2020 Feb 11 doi: 10.1016/j.canrad.2019.09.008. PMID: 32057645
Nasopharyngeal carcinoma.
Brennan B
Orphanet J Rare Dis 2006 Jun 26;1:23. doi: 10.1186/1750-1172-1-23. PMID: 16800883Free PMC Article

Clinical prediction guides

Association of HLA diversity with the risk of 25 cancers in the UK Biobank.
Wang QL, Wang TM, Deng CM, Zhang WL, He YQ, Xue WQ, Liao Y, Yang DW, Zheng MQ, Jia WH
EBioMedicine 2023 Jun;92:104588. Epub 2023 May 4 doi: 10.1016/j.ebiom.2023.104588. PMID: 37148584Free PMC Article
Low vitamin D exposure and risk of nasopharyngeal carcinoma: Observational and genetic evidence from a multicenter case-control study.
Mai ZM, Ngan RK, Ng WT, Lin JH, Kwong DL, Yuen KT, Lee CK, Leung JN, Ip DK, Chan YH, Lee AW, Lung ML, Lam TH, Ho SY
Clin Nutr 2021 Sep;40(9):5180-5188. Epub 2021 Aug 8 doi: 10.1016/j.clnu.2021.07.034. PMID: 34464857
Genetic variants in NKG2D axis and susceptibility to Epstein-Barr virus-induced nasopharyngeal carcinoma.
Viet NH, Trung NQ, Dong LT, Trung LQ, Espinoza JL
J Cancer Res Clin Oncol 2021 Mar;147(3):713-723. Epub 2021 Jan 3 doi: 10.1007/s00432-020-03475-5. PMID: 33392659
Elevated antibodies against Epstein-Barr virus among individuals predicted to carry nasopharyngeal carcinoma susceptibility variants.
Coghill AE, Hsu WL, Yang Q, Wang CP, Lou PJ, Yu KJ, Yu G, Diehl SR, Chen CJ, Goldstein AM, Hildesheim A
J Gen Virol 2018 Sep;99(9):1268-1273. Epub 2018 Jul 5 doi: 10.1099/jgv.0.001115. PMID: 29975184Free PMC Article
HLA-DRB1 allele polymorphism and nasopharyngeal carcinoma risk: a meta-analysis.
Yao K, Yang S, Shen J, Zhang R, Li L
Eur Arch Otorhinolaryngol 2017 Jan;274(1):297-303. Epub 2016 Aug 17 doi: 10.1007/s00405-016-4264-2. PMID: 27535842

Recent systematic reviews

Glutathione S-transferase theta 1 (GSTT1) deletion polymorphism and susceptibility to head and neck carcinoma: a systematic review with five analyses.
Sadafi S, Choubsaz P, Kazemeini SMM, Imani MM, Sadeghi M
BMC Cancer 2024 Jul 22;24(1):885. doi: 10.1186/s12885-024-12618-7. PMID: 39039477Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • Gene
      Related information in NCBI Gene
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

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