U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Infant Acute Undifferentiated Leukemia

MedGen UID:
926424
•Concept ID:
C4288892
•
Neoplastic Process

Definition

An acute undifferentiated leukemia that occurs in infancy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfant Acute Undifferentiated Leukemia

Professional guidelines

PubMed

Treatment including anthracyclines versus treatment not including anthracyclines for childhood cancer.
van Dalen EC, Raphaël MF, Caron HN, Kremer LC
Cochrane Database Syst Rev 2014 Sep 4;2014(9):CD006647. doi: 10.1002/14651858.CD006647.pub4. PMID: 25188452Free PMC Article
Treatment including anthracyclines versus treatment not including anthracyclines for childhood cancer.
van Dalen EC, Raphaël MF, Caron HN, Kremer LC
Cochrane Database Syst Rev 2011 Jan 19;(1):CD006647. doi: 10.1002/14651858.CD006647.pub3. PMID: 21249679
Treatment of relapsed or refractory acute leukemia in childhood with bisantrene combined with high dose aracytine.
Leblanc T, Deméocq F, Leverger G, Baruchel A, Lemerle S, Vannier JP, Nelken B, Guillot T, Schaison G
Med Pediatr Oncol 1994;22(2):119-24. doi: 10.1002/mpo.2950220211. PMID: 8259097

Recent clinical studies

Etiology

Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia.
Isobe T, Takagi M, Sato-Otsubo A, Nishimura A, Nagae G, Yamagishi C, Tamura M, Tanaka Y, Asada S, Takeda R, Tsuchiya A, Wang X, Yoshida K, Nannya Y, Ueno H, Akazawa R, Kato I, Mikami T, Watanabe K, Sekiguchi M, Seki M, Kimura S, Hiwatari M, Kato M, Fukuda S, Tatsuno K, Tsutsumi S, Kanai A, Inaba T, Shiozawa Y, Shiraishi Y, Chiba K, Tanaka H, Kotecha RS, Cruickshank MN, Ishikawa F, Morio T, Eguchi M, Deguchi T, Kiyokawa N, Arakawa Y, Koh K, Aoki Y, Ishihara T, Tomizawa D, Miyamura T, Ishii E, Mizutani S, Wilson NK, Göttgens B, Miyano S, Kitamura T, Goyama S, Yokoyama A, Aburatani H, Ogawa S, Takita J
Nat Commun 2022 Aug 30;13(1):4501. doi: 10.1038/s41467-022-32266-4. PMID: 36042201Free PMC Article
CD2 and CD7 are sensitive flow cytometry screening markers for T-lineage acute leukemia(s): a study of 465 acute leukemia cases.
Rozenova KA, Jevremovic D, Reichard KK, Nguyen P, Otteson GE, Timm MM, Horna P, Olteanu H, Shi M
Hum Pathol 2021 Aug;114:66-73. Epub 2021 May 18 doi: 10.1016/j.humpath.2021.05.007. PMID: 34019867
Acute undifferentiated leukemia: data on incidence and outcomes from a large population-based database.
Qasrawi A, Gomes V, Chacko CA, Mansour A, Kesler M, Arora R, Wei S, Ramlal R, Munker R
Leuk Res 2020 Feb;89:106301. Epub 2020 Jan 17 doi: 10.1016/j.leukres.2020.106301. PMID: 31982153
Treatment including anthracyclines versus treatment not including anthracyclines for childhood cancer.
van Dalen EC, Raphaël MF, Caron HN, Kremer LC
Cochrane Database Syst Rev 2014 Sep 4;2014(9):CD006647. doi: 10.1002/14651858.CD006647.pub4. PMID: 25188452Free PMC Article
Clinical presentations of acute leukemia.
Shahab F, Raziq F
J Coll Physicians Surg Pak 2014 Jul;24(7):472-6. PMID: 25052968

Diagnosis

CD2 and CD7 are sensitive flow cytometry screening markers for T-lineage acute leukemia(s): a study of 465 acute leukemia cases.
Rozenova KA, Jevremovic D, Reichard KK, Nguyen P, Otteson GE, Timm MM, Horna P, Olteanu H, Shi M
Hum Pathol 2021 Aug;114:66-73. Epub 2021 May 18 doi: 10.1016/j.humpath.2021.05.007. PMID: 34019867
Acute undifferentiated leukemia: data on incidence and outcomes from a large population-based database.
Qasrawi A, Gomes V, Chacko CA, Mansour A, Kesler M, Arora R, Wei S, Ramlal R, Munker R
Leuk Res 2020 Feb;89:106301. Epub 2020 Jan 17 doi: 10.1016/j.leukres.2020.106301. PMID: 31982153
Survival of patients with mixed phenotype acute leukemias: A large population-based study.
Shi R, Munker R
Leuk Res 2015 Jun;39(6):606-16. Epub 2015 Mar 28 doi: 10.1016/j.leukres.2015.03.012. PMID: 25858895
Clinical presentations of acute leukemia.
Shahab F, Raziq F
J Coll Physicians Surg Pak 2014 Jul;24(7):472-6. PMID: 25052968
Immunophenotypic profile of acute leukemia: critical analysis and insights gained at a tertiary care center in India.
Gujral S, Badrinath Y, Kumar A, Subramanian PG, Raje G, Jain H, Pais A, Amre Kadam PS, Banavali SD, Arora B, Kumar P, Hari Menon VG, Kurkure PA, Parikh PM, Mahadik S, Chogule AB, Shinde SC, Nair CN
Cytometry B Clin Cytom 2009 May;76(3):199-205. doi: 10.1002/cyto.b.20451. PMID: 18803279

Therapy

Parental occupational exposure to benzene and the risk of childhood and adolescent acute lymphoblastic leukaemia: a population-based study.
Heck JE, He D, Contreras ZA, Ritz B, Olsen J, Hansen J
Occup Environ Med 2019 Aug;76(8):527-529. Epub 2019 May 28 doi: 10.1136/oemed-2019-105738. PMID: 31138675Free PMC Article
Treatment including anthracyclines versus treatment not including anthracyclines for childhood cancer.
van Dalen EC, Raphaël MF, Caron HN, Kremer LC
Cochrane Database Syst Rev 2014 Sep 4;2014(9):CD006647. doi: 10.1002/14651858.CD006647.pub4. PMID: 25188452Free PMC Article
Treatment including anthracyclines versus treatment not including anthracyclines for childhood cancer.
van Dalen EC, Raphaël MF, Caron HN, Kremer LC
Cochrane Database Syst Rev 2011 Jan 19;(1):CD006647. doi: 10.1002/14651858.CD006647.pub3. PMID: 21249679
Heterogeneity of acute "undifferentiated" leukemia of childhood: ultrastructural, immunophenotypic, and karyotypic analyses.
Stork L, Wilson H, Mierau G, Hays T, Morse H, Jamieson B, Barczuk L, Berry R, Odom L
Am J Pediatr Hematol Oncol 1990 Spring;12(1):34-44. doi: 10.1097/00043426-199021000-00007. PMID: 2309978
Non-Hodgkin's lymphoma in children.
Pinkel D, Johnson W, Aur RJ
Br J Cancer Suppl 1975 Mar;2:298-323. PMID: 1101924Free PMC Article

Prognosis

Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia.
Isobe T, Takagi M, Sato-Otsubo A, Nishimura A, Nagae G, Yamagishi C, Tamura M, Tanaka Y, Asada S, Takeda R, Tsuchiya A, Wang X, Yoshida K, Nannya Y, Ueno H, Akazawa R, Kato I, Mikami T, Watanabe K, Sekiguchi M, Seki M, Kimura S, Hiwatari M, Kato M, Fukuda S, Tatsuno K, Tsutsumi S, Kanai A, Inaba T, Shiozawa Y, Shiraishi Y, Chiba K, Tanaka H, Kotecha RS, Cruickshank MN, Ishikawa F, Morio T, Eguchi M, Deguchi T, Kiyokawa N, Arakawa Y, Koh K, Aoki Y, Ishihara T, Tomizawa D, Miyamura T, Ishii E, Mizutani S, Wilson NK, Göttgens B, Miyano S, Kitamura T, Goyama S, Yokoyama A, Aburatani H, Ogawa S, Takita J
Nat Commun 2022 Aug 30;13(1):4501. doi: 10.1038/s41467-022-32266-4. PMID: 36042201Free PMC Article
CD2 and CD7 are sensitive flow cytometry screening markers for T-lineage acute leukemia(s): a study of 465 acute leukemia cases.
Rozenova KA, Jevremovic D, Reichard KK, Nguyen P, Otteson GE, Timm MM, Horna P, Olteanu H, Shi M
Hum Pathol 2021 Aug;114:66-73. Epub 2021 May 18 doi: 10.1016/j.humpath.2021.05.007. PMID: 34019867
Acute undifferentiated leukemia: data on incidence and outcomes from a large population-based database.
Qasrawi A, Gomes V, Chacko CA, Mansour A, Kesler M, Arora R, Wei S, Ramlal R, Munker R
Leuk Res 2020 Feb;89:106301. Epub 2020 Jan 17 doi: 10.1016/j.leukres.2020.106301. PMID: 31982153
Survival of patients with mixed phenotype acute leukemias: A large population-based study.
Shi R, Munker R
Leuk Res 2015 Jun;39(6):606-16. Epub 2015 Mar 28 doi: 10.1016/j.leukres.2015.03.012. PMID: 25858895
Clinical presentations of acute leukemia.
Shahab F, Raziq F
J Coll Physicians Surg Pak 2014 Jul;24(7):472-6. PMID: 25052968

Clinical prediction guides

Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia.
Isobe T, Takagi M, Sato-Otsubo A, Nishimura A, Nagae G, Yamagishi C, Tamura M, Tanaka Y, Asada S, Takeda R, Tsuchiya A, Wang X, Yoshida K, Nannya Y, Ueno H, Akazawa R, Kato I, Mikami T, Watanabe K, Sekiguchi M, Seki M, Kimura S, Hiwatari M, Kato M, Fukuda S, Tatsuno K, Tsutsumi S, Kanai A, Inaba T, Shiozawa Y, Shiraishi Y, Chiba K, Tanaka H, Kotecha RS, Cruickshank MN, Ishikawa F, Morio T, Eguchi M, Deguchi T, Kiyokawa N, Arakawa Y, Koh K, Aoki Y, Ishihara T, Tomizawa D, Miyamura T, Ishii E, Mizutani S, Wilson NK, Göttgens B, Miyano S, Kitamura T, Goyama S, Yokoyama A, Aburatani H, Ogawa S, Takita J
Nat Commun 2022 Aug 30;13(1):4501. doi: 10.1038/s41467-022-32266-4. PMID: 36042201Free PMC Article
CD2 and CD7 are sensitive flow cytometry screening markers for T-lineage acute leukemia(s): a study of 465 acute leukemia cases.
Rozenova KA, Jevremovic D, Reichard KK, Nguyen P, Otteson GE, Timm MM, Horna P, Olteanu H, Shi M
Hum Pathol 2021 Aug;114:66-73. Epub 2021 May 18 doi: 10.1016/j.humpath.2021.05.007. PMID: 34019867
Acute undifferentiated leukemia: data on incidence and outcomes from a large population-based database.
Qasrawi A, Gomes V, Chacko CA, Mansour A, Kesler M, Arora R, Wei S, Ramlal R, Munker R
Leuk Res 2020 Feb;89:106301. Epub 2020 Jan 17 doi: 10.1016/j.leukres.2020.106301. PMID: 31982153
Clinical presentations of acute leukemia.
Shahab F, Raziq F
J Coll Physicians Surg Pak 2014 Jul;24(7):472-6. PMID: 25052968
Immunophenotype of adult and childhood acute lymphoblastic leukemia: changes at first relapse and clinico-prognostic implications.
Guglielmi C, Cordone I, Boecklin F, Masi S, Valentini T, Vegna ML, Ferrari A, Testi AM, Foa R
Leukemia 1997 Sep;11(9):1501-7. doi: 10.1038/sj.leu.2400772. PMID: 9305605

Recent systematic reviews

Treatment including anthracyclines versus treatment not including anthracyclines for childhood cancer.
van Dalen EC, Raphaël MF, Caron HN, Kremer LC
Cochrane Database Syst Rev 2014 Sep 4;2014(9):CD006647. doi: 10.1002/14651858.CD006647.pub4. PMID: 25188452Free PMC Article
Treatment including anthracyclines versus treatment not including anthracyclines for childhood cancer.
van Dalen EC, Raphaël MF, Caron HN, Kremer LC
Cochrane Database Syst Rev 2011 Jan 19;(1):CD006647. doi: 10.1002/14651858.CD006647.pub3. PMID: 21249679

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...