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Decreased proportion of naive B cells

MedGen UID:
892943
•Concept ID:
C4072911
•
Finding
Synonym: Decreased naive B cell count
 
HPO: HP:0030372

Definition

A reduction below normal proportion of naive B cells (CD19+/CD27-/IgD+/IgM+) relative to total number of B cells. Naive B cells represent one of the subtypes of B cells in the peripheral blood, and are B cells that have not been exposed to antigen. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased proportion of naive B cells

Professional guidelines

PubMed

Peripheral blood cellular dynamics of rheumatoid arthritis treatment informs about efficacy of response to disease modifying drugs.
Hedman ÅK, Winter E, Yoosuf N, Benita Y, Berg L, Brynedal B, Folkersen L, Klareskog L, Maciejewski M, Sirota-Madi A, Spector Y, Ziemek D, Padyukov L, Shen-Orr SS, Jelinsky SA
Sci Rep 2023 Jun 21;13(1):10058. doi: 10.1038/s41598-023-36999-0. PMID: 37344505Free PMC Article
Cladribine treatment specifically affects peripheral blood memory B cell clones and clonal expansion in multiple sclerosis patients.
Ruschil C, Gabernet G, Kemmerer CL, Jarboui MA, Klose F, Poli S, Ziemann U, Nahnsen S, Kowarik MC
Front Immunol 2023;14:1133967. Epub 2023 Mar 7 doi: 10.3389/fimmu.2023.1133967. PMID: 36960053Free PMC Article
Protein-losing Enteropathy as a Complication and/or Differential Diagnosis of Common Variable Immunodeficiency.
Sanges S, Germain N, Vignes S, Séguy D, Stabler S, Etienne N, Terriou L, Launay D, Hachulla É, Huglo D, Dubucquoi S, Labalette M, Lefèvre G
J Clin Immunol 2022 Oct;42(7):1461-1472. Epub 2022 Jun 23 doi: 10.1007/s10875-022-01299-1. PMID: 35737255

Recent clinical studies

Etiology

Single-cell transcriptome analysis reveals functional changes in tumour-infiltrating B lymphocytes after chemotherapy in oesophageal squamous cell carcinoma.
Nakamura S, Ohuchida K, Ohtsubo Y, Yamada Y, Tsutsumi C, Okuda S, Hisano K, Mochida Y, Shinkawa T, Iwamoto C, Torata N, Mizuuchi Y, Shindo K, Nakata K, Moriyama T, Torisu T, Nagai E, Morisaki T, Kitazono T, Oda Y, Nakamura M
Clin Transl Med 2023 Jan;13(1):e1181. doi: 10.1002/ctm2.1181. PMID: 36650114Free PMC Article
Sustained immunotolerance in multiple sclerosis after stem cell transplant.
Visweswaran M, Hendrawan K, Massey JC, Khoo ML, Ford CD, Zaunders JJ, Withers B, Sutton IJ, Ma DDF, Moore JJ
Ann Clin Transl Neurol 2022 Feb;9(2):206-220. Epub 2022 Feb 1 doi: 10.1002/acn3.51510. PMID: 35106961Free PMC Article
Altered B lymphocyte homeostasis and functions in systemic sclerosis.
Forestier A, Guerrier T, Jouvray M, Giovannelli J, Lefèvre G, Sobanski V, Hauspie C, Hachulla E, Hatron PY, Zéphir H, Vermersch P, Labalette M, Launay D, Dubucquoi S
Autoimmun Rev 2018 Mar;17(3):244-255. Epub 2018 Jan 16 doi: 10.1016/j.autrev.2017.10.015. PMID: 29343447
Could Lymphocyte Profiling be Useful to Diagnose Systemic Autoimmune Diseases?
Carvajal Alegria G, Gazeau P, Hillion S, Daïen CI, Cornec DYK
Clin Rev Allergy Immunol 2017 Oct;53(2):219-236. doi: 10.1007/s12016-017-8608-5. PMID: 28474288
Regulatory B and T cell responses in patients with autoimmune thyroid disease and healthy controls.
Kristensen B
Dan Med J 2016 Feb;63(2) PMID: 26836805

Diagnosis

Integrative Analysis Reveals STC2 as a Prognostic Biomarker of Laryngeal Squamous Cell Carcinoma.
Zhong R, Zhan J, Zhang S
Appl Biochem Biotechnol 2024 Jul;196(7):3891-3913. Epub 2023 Oct 4 doi: 10.1007/s12010-023-04727-z. PMID: 37792175
Protein-losing Enteropathy as a Complication and/or Differential Diagnosis of Common Variable Immunodeficiency.
Sanges S, Germain N, Vignes S, Séguy D, Stabler S, Etienne N, Terriou L, Launay D, Hachulla É, Huglo D, Dubucquoi S, Labalette M, Lefèvre G
J Clin Immunol 2022 Oct;42(7):1461-1472. Epub 2022 Jun 23 doi: 10.1007/s10875-022-01299-1. PMID: 35737255
Proportion versus absolute counts of B cell populations in the assessment of immunological profiles of kidney transplant recipients.
Gama A, Désy O, Béland S, Bouchard-Boivin F, Marcoux M, De Serres SA
Transpl Immunol 2022 Feb;70:101519. Epub 2021 Dec 24 doi: 10.1016/j.trim.2021.101519. PMID: 34958918
Immune Cell Landscape in Gastric Cancer.
Yang Y, He W, Wang ZR, Wang YJ, Li LL, Lu JZ, Tao Y, Zhang J, Fu SJ, Wang ZP, Liu SH
Biomed Res Int 2021;2021:1930706. Epub 2021 Jan 9 doi: 10.1155/2021/1930706. PMID: 33575321Free PMC Article
Could Lymphocyte Profiling be Useful to Diagnose Systemic Autoimmune Diseases?
Carvajal Alegria G, Gazeau P, Hillion S, Daïen CI, Cornec DYK
Clin Rev Allergy Immunol 2017 Oct;53(2):219-236. doi: 10.1007/s12016-017-8608-5. PMID: 28474288

Therapy

mTOR inhibition attenuates cTfh cell dysregulation and chronic T-cell activation in multilineage immune cytopenias.
Kumar D, Nguyen TH, Bennett CM, Prince C, Lucas L, Park S, Lawrence T, Chappelle K, Ishaq M, Waller EK, Prahalad S, Briones M, Chandrakasan S
Blood 2023 Jan 19;141(3):238-243. doi: 10.1182/blood.2022015966. PMID: 36206504Free PMC Article
Sustained immunotolerance in multiple sclerosis after stem cell transplant.
Visweswaran M, Hendrawan K, Massey JC, Khoo ML, Ford CD, Zaunders JJ, Withers B, Sutton IJ, Ma DDF, Moore JJ
Ann Clin Transl Neurol 2022 Feb;9(2):206-220. Epub 2022 Feb 1 doi: 10.1002/acn3.51510. PMID: 35106961Free PMC Article
Efficacy of tocilizumab therapy in a patient with severe pancytopenia associated with a STAT3 gain-of-function mutation.
Wang W, Liu L, Hui X, Wang Y, Ying W, Zhou Q, Hou J, Yang M, Sun B, Sun J, Wang X
BMC Immunol 2021 Mar 17;22(1):19. doi: 10.1186/s12865-021-00411-1. PMID: 33731004Free PMC Article
Effect of Ocrelizumab in Blood Leukocytes of Patients With Primary Progressive MS.
Fernández-Velasco JI, Kuhle J, Monreal E, Meca-Lallana V, Meca-Lallana J, Izquierdo G, Gascón-Giménez F, Sainz de la Maza S, Walo-Delgado PE, Maceski A, Rodríguez-Martín E, Roldán E, Villarrubia N, Saiz A, Blanco Y, Sánchez P, Carreón-Guarnizo E, Aladro Y, Brieva L, Íñiguez C, González-Suárez I, Rodríguez de Antonio LA, Masjuan J, Costa-Frossard L, Villar LM
Neurol Neuroimmunol Neuroinflamm 2021 Mar 4;8(2) Epub 2021 Jan 6 doi: 10.1212/NXI.0000000000000940. PMID: 33408167Free PMC Article
Effect of Antiretroviral Therapy on the Memory and Activation Profiles of B Cells in HIV-Infected African Women.
Tanko RF, Soares AP, Müller TL, Garrett NJ, Samsunder N, Abdool Karim Q, Abdool Karim SS, Riou C, Burgers WA
J Immunol 2017 Feb 1;198(3):1220-1228. Epub 2016 Dec 30 doi: 10.4049/jimmunol.1601560. PMID: 28039305Free PMC Article

Prognosis

Single-cell transcriptome analysis reveals functional changes in tumour-infiltrating B lymphocytes after chemotherapy in oesophageal squamous cell carcinoma.
Nakamura S, Ohuchida K, Ohtsubo Y, Yamada Y, Tsutsumi C, Okuda S, Hisano K, Mochida Y, Shinkawa T, Iwamoto C, Torata N, Mizuuchi Y, Shindo K, Nakata K, Moriyama T, Torisu T, Nagai E, Morisaki T, Kitazono T, Oda Y, Nakamura M
Clin Transl Med 2023 Jan;13(1):e1181. doi: 10.1002/ctm2.1181. PMID: 36650114Free PMC Article
Regulatory T and B cells in transient hypogammaglobulinemia of infancy.
Emsen A, Uçaryılmaz H, Güler T, Artaç H
Turk J Pediatr 2022;64(2):228-238. doi: 10.24953/turkjped.2021.83. PMID: 35611411
Sustained immunotolerance in multiple sclerosis after stem cell transplant.
Visweswaran M, Hendrawan K, Massey JC, Khoo ML, Ford CD, Zaunders JJ, Withers B, Sutton IJ, Ma DDF, Moore JJ
Ann Clin Transl Neurol 2022 Feb;9(2):206-220. Epub 2022 Feb 1 doi: 10.1002/acn3.51510. PMID: 35106961Free PMC Article
Immune Cell Landscape in Gastric Cancer.
Yang Y, He W, Wang ZR, Wang YJ, Li LL, Lu JZ, Tao Y, Zhang J, Fu SJ, Wang ZP, Liu SH
Biomed Res Int 2021;2021:1930706. Epub 2021 Jan 9 doi: 10.1155/2021/1930706. PMID: 33575321Free PMC Article
Could Lymphocyte Profiling be Useful to Diagnose Systemic Autoimmune Diseases?
Carvajal Alegria G, Gazeau P, Hillion S, Daïen CI, Cornec DYK
Clin Rev Allergy Immunol 2017 Oct;53(2):219-236. doi: 10.1007/s12016-017-8608-5. PMID: 28474288

Clinical prediction guides

Human umbilical cord-derived mesenchymal stem cell transplantation improves the long COVID.
Tang Y, Zou X, Liu P, Dai Y, Wang S, Su X, Yu Y, Tang W, Zhou J, Li C, Mei H, Xiao N, Ou Y, Wang J, Lu G, Lin G, Cheng L
J Med Virol 2024 Jun;96(6):e29757. doi: 10.1002/jmv.29757. PMID: 38899432
Regulatory T and B cells in transient hypogammaglobulinemia of infancy.
Emsen A, Uçaryılmaz H, Güler T, Artaç H
Turk J Pediatr 2022;64(2):228-238. doi: 10.24953/turkjped.2021.83. PMID: 35611411
Abnormalities of bone marrow B cells and plasma cells in primary immune thrombocytopenia.
Yu TS, Wang HY, Zhao YJ, Yu YF, Hou Y, Liu S, Han PP, Ni XF, Ji XB, Peng J, Liu XG, Hou M
Blood Adv 2021 Oct 26;5(20):4087-4101. doi: 10.1182/bloodadvances.2020003860. PMID: 34507351Free PMC Article
Altered B lymphocyte homeostasis and functions in systemic sclerosis.
Forestier A, Guerrier T, Jouvray M, Giovannelli J, Lefèvre G, Sobanski V, Hauspie C, Hachulla E, Hatron PY, Zéphir H, Vermersch P, Labalette M, Launay D, Dubucquoi S
Autoimmun Rev 2018 Mar;17(3):244-255. Epub 2018 Jan 16 doi: 10.1016/j.autrev.2017.10.015. PMID: 29343447
Could Lymphocyte Profiling be Useful to Diagnose Systemic Autoimmune Diseases?
Carvajal Alegria G, Gazeau P, Hillion S, Daïen CI, Cornec DYK
Clin Rev Allergy Immunol 2017 Oct;53(2):219-236. doi: 10.1007/s12016-017-8608-5. PMID: 28474288

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