Definition

An abnormal form or size of neutrophils. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal neutrophil morphology

Abnormal immune system morphology
- Abnormal cellular immune system morphology
  - Abnormal leukocyte morphology
    - Abnormal myeloid leukocyte morphology
      - Abnormal granulocyte morphology
        Abnormality of neutrophils
        Abnormal neutrophil morphology
        Absent neutrophil specific granules
        Absent neutrophil lactoferrin
        Diminished neutrophil myeloperoxidase activity
        Giant neutrophil granules
        Hypersegmentation of neutrophil nuclei
        Hyposegmentation of neutrophil nuclei
        Increased neutrophil mitochondria
        Increased neutrophil nuclear projections
        Increased neutrophil ribosomes
        Neutrophil inclusion bodies
        Leukocyte inclusion bodies
        Pyknotic bone marrow neutrophils

Professional guidelines

PubMed

Essential thrombocythemia: 2024 update on diagnosis, risk stratification, and management.

Tefferi A, Vannucchi AM, Barbui T
Am J Hematol 2024 Apr;99(4):697-718. Epub 2024 Jan 25 doi: 10.1002/ajh.27216. PMID: 38269572

The 2021 European Alliance of Associations for Rheumatology/American College of Rheumatology points to consider for diagnosis and management of autoinflammatory type I interferonopathies: CANDLE/PRAAS, SAVI and AGS.

Cetin Gedik K, Lamot L, Romano M, Demirkaya E, Piskin D, Torreggiani S, Adang LA, Armangue T, Barchus K, Cordova DR, Crow YJ, Dale RC, Durrant KL, Eleftheriou D, Fazzi EM, Gattorno M, Gavazzi F, Hanson EP, Lee-Kirsch MA, Montealegre Sanchez GA, Neven B, Orcesi S, Ozen S, Poli MC, Schumacher E, Tonduti D, Uss K, Aletaha D, Feldman BM, Vanderver A, Brogan PA, Goldbach-Mansky R
Ann Rheum Dis 2022 May;81(5):601-613. Epub 2022 Jan 27 doi: 10.1136/annrheumdis-2021-221814. PMID: 35086813 Free PMC Article

Autoimmune Neutropenia Updates: Etiology, Pathology, and Treatment.

Afzal W, Owlia MB, Hasni S, Newman KA
South Med J 2017 Apr;110(4):300-307. doi: 10.14423/SMJ.0000000000000637. PMID: 28376530

See all (54)

Recent clinical studies

Diagnosis

A Novel CEBPE Variant Causes Severe Infections and Profound Neutropenia.

Banday AZ, Kaur A, Akagi T, Bhattarai D, Muraoka M, Dev D, Das J, Sachdeva MUS, Karmakar I, Arora K, Kaur G, Pandiarajan V, Jindal AK, Wada T, Koeffler HP, Suri D, Ahluwalia J, Kanegane H, Bhatia P, Rawat A, Singh S
J Clin Immunol 2022 Oct;42(7):1434-1450. Epub 2022 Jun 20 doi: 10.1007/s10875-022-01304-7. PMID: 35726044

See all (1)

Clinical prediction guides

A Novel CEBPE Variant Causes Severe Infections and Profound Neutropenia.

Banday AZ, Kaur A, Akagi T, Bhattarai D, Muraoka M, Dev D, Das J, Sachdeva MUS, Karmakar I, Arora K, Kaur G, Pandiarajan V, Jindal AK, Wada T, Koeffler HP, Suri D, Ahluwalia J, Kanegane H, Bhatia P, Rawat A, Singh S
J Clin Immunol 2022 Oct;42(7):1434-1450. Epub 2022 Jun 20 doi: 10.1007/s10875-022-01304-7. PMID: 35726044

See all (1)

Synonym:	Abnormality of neutrophil morphology

HPO:	HP:0011992

MedGen

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Abnormal neutrophil morphology

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Diagnosis

Clinical prediction guides

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