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Diminished neutrophil myeloperoxidase activity

MedGen UID:
1052532
•Concept ID:
CN377344
•
Finding
HPO: HP:6000513

Definition

Activity of the enzyme myeloperoxidase (EC 1.11.1.7) in neutrophils below the lower limit of normal. This feature can be measured by peroxidase cytochemistry or biochemical assays. Myeloperoxidase is a lysosomal hemoprotein located in the azurophilic granules of polymorphonuclear leukocytes and monocytes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiminished neutrophil myeloperoxidase activity

Conditions with this feature

Myeloperoxidase deficiency
MedGen UID:
96015
•Concept ID:
C0398595
•
Disease or Syndrome
A rare primary immunodeficiency due to a defect in innate immunity characterized by a marked decrease or absence of myeloperoxidase activity in neutrophils and monocytes. Clinically, most patients are asymptomatic. Occasionally, severe infectious complications may occur, particularly recurrent candida infections, being especially severe in the setting of comorbid diabetes mellitus.
See: Condition Record
Myeloperoxidase deficiency

Professional guidelines

PubMed

Elevated Systemic Levels of Eosinophil, Neutrophil, and Mast Cell Granular Proteins in Strongyloides Stercoralis Infection that Diminish following Treatment.
Rajamanickam A, Munisankar S, Bhootra Y, Dolla CK, Nutman TB, Babu S
Front Immunol 2018;9:207. Epub 2018 Feb 9 doi: 10.3389/fimmu.2018.00207. PMID: 29479356Free PMC Article

Recent clinical studies

Etiology

Comparing the oxidative functions of neutrophil myeloperoxidase and cytochrome P450 enzymes in drug metabolism.
Tran NH, Mosa FES, Barakat K, El-Kadi AOS, Whittal R, Siraki AG
Chem Biol Interact 2024 Apr 1;392:110942. Epub 2024 Mar 7 doi: 10.1016/j.cbi.2024.110942. PMID: 38458309
Increase of Neutrophil Activation Markers in Venous Thrombosis-Contribution of Circulating Activated Protein C.
Martos L, Oto J, Fernández-Pardo Á, Plana E, Solmoirago MJ, Cana F, Hervás D, Bonanad S, Ferrando F, España F, Navarro S, Medina P
Int J Mol Sci 2020 Aug 6;21(16) doi: 10.3390/ijms21165651. PMID: 32781781Free PMC Article
Aerobic Exercise Protects from Pseudomonas aeruginosa-Induced Pneumonia in Elderly Mice.
Stravinskas Durigon T, MacKenzie B, Carneiro Oliveira-Junior M, Santos-Dias A, De Angelis K, Malfitano C, Kelly da Palma R, Moreno Guerra J, Damaceno-Rodrigues NR, Garcia Caldini E, de Almeida FM, Aquino-Santos HC, Rigonato-Oliveira NC, Leal de Oliveira DB, Aimbire F, Ligeiro de Oliveira AP, Franco de Oliveira LV, Durigon EL, Hiemstra PS, Vieira RP
J Innate Immun 2018;10(4):279-290. Epub 2018 May 29 doi: 10.1159/000488953. PMID: 29843140Free PMC Article
Myeloperoxidase deficiency preserves vasomotor function in humans.
Rudolph TK, Wipper S, Reiter B, Rudolph V, Coym A, Detter C, Lau D, Klinke A, Friedrichs K, Rau T, Pekarova M, Russ D, Knöll K, Kolk M, Schroeder B, Wegscheider K, Andresen H, Schwedhelm E, Boeger R, Ehmke H, Baldus S
Eur Heart J 2012 Jul;33(13):1625-34. Epub 2011 Jun 30 doi: 10.1093/eurheartj/ehr193. PMID: 21724624Free PMC Article
Recombinant factor XIII mitigates hemorrhagic shock-induced organ dysfunction.
Zaets SB, Xu DZ, Lu Q, Feketova E, Berezina TL, Malinina IV, Deitch EA, Olsen EH
J Surg Res 2011 Apr;166(2):e135-42. Epub 2010 Dec 31 doi: 10.1016/j.jss.2010.12.001. PMID: 21276979Free PMC Article

Diagnosis

Eosinophils oxidize damage-associated molecular pattern molecules derived from stressed cells.
Lotfi R, Herzog GI, DeMarco RA, Beer-Stolz D, Lee JJ, Rubartelli A, Schrezenmeier H, Lotze MT
J Immunol 2009 Oct 15;183(8):5023-31. Epub 2009 Sep 30 doi: 10.4049/jimmunol.0900504. PMID: 19794066
Effects of ion composition and tonicity on human neutrophil antibacterial activity.
Verghese MW, Boucher RC
Am J Respir Cell Mol Biol 1998 Dec;19(6):920-8. doi: 10.1165/ajrcmb.19.6.3290. PMID: 9843926
Myeloperoxidase isoform activities released by human neutrophils in response to dental and periodontal bacteria.
Miyasaki KT, Nemirovskiy E
Oral Microbiol Immunol 1997 Feb;12(1):27-32. doi: 10.1111/j.1399-302x.1997.tb00363.x. PMID: 9151641
Lower respiratory tract abnormalities in rheumatoid interstitial lung disease. Potential role of neutrophils in lung injury.
Garcia JG, James HL, Zinkgraf S, Perlman MB, Keogh BA
Am Rev Respir Dis 1987 Oct;136(4):811-7. doi: 10.1164/ajrccm/136.4.811. PMID: 2821854
Immunosuppression by activated human neutrophils. Dependence on the myeloperoxidase system.
el-Hag A, Clark RA
J Immunol 1987 Oct 1;139(7):2406-13. PMID: 2821114

Therapy

Esculin alleviates LPS-induced acute lung injury via inhibiting neutrophil recruitment and migration.
Ni J, Li G, Dai N, Quan Z, Tong H, Liu Y
Int Immunopharmacol 2023 Jun;119:110177. Epub 2023 Apr 15 doi: 10.1016/j.intimp.2023.110177. PMID: 37068336Free PMC Article
Aerobic Exercise Protects from Pseudomonas aeruginosa-Induced Pneumonia in Elderly Mice.
Stravinskas Durigon T, MacKenzie B, Carneiro Oliveira-Junior M, Santos-Dias A, De Angelis K, Malfitano C, Kelly da Palma R, Moreno Guerra J, Damaceno-Rodrigues NR, Garcia Caldini E, de Almeida FM, Aquino-Santos HC, Rigonato-Oliveira NC, Leal de Oliveira DB, Aimbire F, Ligeiro de Oliveira AP, Franco de Oliveira LV, Durigon EL, Hiemstra PS, Vieira RP
J Innate Immun 2018;10(4):279-290. Epub 2018 May 29 doi: 10.1159/000488953. PMID: 29843140Free PMC Article
Elevated Systemic Levels of Eosinophil, Neutrophil, and Mast Cell Granular Proteins in Strongyloides Stercoralis Infection that Diminish following Treatment.
Rajamanickam A, Munisankar S, Bhootra Y, Dolla CK, Nutman TB, Babu S
Front Immunol 2018;9:207. Epub 2018 Feb 9 doi: 10.3389/fimmu.2018.00207. PMID: 29479356Free PMC Article
Mast Cell Stabilization Ameliorates Autoimmune Anti-Myeloperoxidase Glomerulonephritis.
Gan PY, O'Sullivan KM, Ooi JD, Alikhan MA, Odobasic D, Summers SA, Kitching AR, Holdsworth SR
J Am Soc Nephrol 2016 May;27(5):1321-33. Epub 2015 Sep 15 doi: 10.1681/ASN.2014090906. PMID: 26374606Free PMC Article
Effects of ion composition and tonicity on human neutrophil antibacterial activity.
Verghese MW, Boucher RC
Am J Respir Cell Mol Biol 1998 Dec;19(6):920-8. doi: 10.1165/ajrcmb.19.6.3290. PMID: 9843926

Prognosis

Role of membrane vitamin E and cytoplasmic glutathione in the regulation of phagocytic functions of neutrophils and monocytes.
Baehner RL, Boxer LA
Am J Pediatr Hematol Oncol 1979 Spring;1(1):71-6. PMID: 396794
Granulocyte function in chronic granulocytic leukaemia. I. Bactericidal and metabolic capabilities during phagocytosis in isolated granulocytes.
Odeberg H, Olofsson T, Olsson I
Br J Haematol 1975 Mar;29(3):427-41. doi: 10.1111/j.1365-2141.1975.tb01840.x. PMID: 172109

Clinical prediction guides

Comparing the oxidative functions of neutrophil myeloperoxidase and cytochrome P450 enzymes in drug metabolism.
Tran NH, Mosa FES, Barakat K, El-Kadi AOS, Whittal R, Siraki AG
Chem Biol Interact 2024 Apr 1;392:110942. Epub 2024 Mar 7 doi: 10.1016/j.cbi.2024.110942. PMID: 38458309
Esculin alleviates LPS-induced acute lung injury via inhibiting neutrophil recruitment and migration.
Ni J, Li G, Dai N, Quan Z, Tong H, Liu Y
Int Immunopharmacol 2023 Jun;119:110177. Epub 2023 Apr 15 doi: 10.1016/j.intimp.2023.110177. PMID: 37068336Free PMC Article
Microbial-derived indoles inhibit neutrophil myeloperoxidase to diminish bystander tissue damage.
Alexeev EE, Dowdell AS, Henen MA, Lanis JM, Lee JS, Cartwright IM, Schaefer REM, Ornelas A, Onyiah JC, Vögeli B, Colgan SP
FASEB J 2021 May;35(5):e21552. doi: 10.1096/fj.202100027R. PMID: 33826788Free PMC Article
Mast Cell Stabilization Ameliorates Autoimmune Anti-Myeloperoxidase Glomerulonephritis.
Gan PY, O'Sullivan KM, Ooi JD, Alikhan MA, Odobasic D, Summers SA, Kitching AR, Holdsworth SR
J Am Soc Nephrol 2016 May;27(5):1321-33. Epub 2015 Sep 15 doi: 10.1681/ASN.2014090906. PMID: 26374606Free PMC Article
Myeloperoxidase deficiency preserves vasomotor function in humans.
Rudolph TK, Wipper S, Reiter B, Rudolph V, Coym A, Detter C, Lau D, Klinke A, Friedrichs K, Rau T, Pekarova M, Russ D, Knöll K, Kolk M, Schroeder B, Wegscheider K, Andresen H, Schwedhelm E, Boeger R, Ehmke H, Baldus S
Eur Heart J 2012 Jul;33(13):1625-34. Epub 2011 Jun 30 doi: 10.1093/eurheartj/ehr193. PMID: 21724624Free PMC Article

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