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Germ cell neoplasia

MedGen UID:
867599
•Concept ID:
C4021985
•
Neoplastic Process
HPO: HP:0100728

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGerm cell neoplasia

Conditions with this feature

Testicular germ cell tumor 1
MedGen UID:
337402
•Concept ID:
C1846164
•
Neoplastic Process
See: Condition Record
Testicular germ cell tumor 1

Professional guidelines

PubMed

Testicular Germ Cell Tumors: Classification, Pathologic Features, Imaging Findings, and Management.
Katabathina VS, Vargas-Zapata D, Monge RA, Nazarullah A, Ganeshan D, Tammisetti V, Prasad SR
Radiographics 2021 Oct;41(6):1698-1716. doi: 10.1148/rg.2021210024. PMID: 34597218
Diagnosis and Management of Intratubular Germ Cell Neoplasia In Situ: A Systematic Review.
Gupta M, Cheaib JG, Patel HD, Sharma R, Zhang A, Bass EB, Pierorazio PM
J Urol 2020 Jul;204(1):33-41. Epub 2020 Jan 22 doi: 10.1097/JU.0000000000000758. PMID: 31967523
Difficult differential diagnoses in testicular pathology.
Ye H, Ulbright TM
Arch Pathol Lab Med 2012 Apr;136(4):435-46. doi: 10.5858/arpa.2011-0475-RA. PMID: 22458906

Recent clinical studies

Etiology

The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.
Moch H, Amin MB, Berney DM, Compérat EM, Gill AJ, Hartmann A, Menon S, Raspollini MR, Rubin MA, Srigley JR, Hoon Tan P, Tickoo SK, Tsuzuki T, Turajlic S, Cree I, Netto GJ
Eur Urol 2022 Nov;82(5):458-468. Epub 2022 Jul 16 doi: 10.1016/j.eururo.2022.06.016. PMID: 35853783
Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Testicular cancer.
Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, Looijenga LHJ
Nat Rev Dis Primers 2018 Oct 5;4(1):29. doi: 10.1038/s41572-018-0029-0. PMID: 30291251
The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.
Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM
Eur Urol 2016 Jul;70(1):93-105. Epub 2016 Feb 28 doi: 10.1016/j.eururo.2016.02.029. PMID: 26935559
Pathogenesis of germ cell neoplasia in testicular dysgenesis and disorders of sex development.
Jørgensen A, Lindhardt Johansen M, Juul A, Skakkebaek NE, Main KM, Rajpert-De Meyts E
Semin Cell Dev Biol 2015 Sep;45:124-37. Epub 2015 Sep 26 doi: 10.1016/j.semcdb.2015.09.013. PMID: 26410164

Diagnosis

The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.
Moch H, Amin MB, Berney DM, Compérat EM, Gill AJ, Hartmann A, Menon S, Raspollini MR, Rubin MA, Srigley JR, Hoon Tan P, Tickoo SK, Tsuzuki T, Turajlic S, Cree I, Netto GJ
Eur Urol 2022 Nov;82(5):458-468. Epub 2022 Jul 16 doi: 10.1016/j.eururo.2022.06.016. PMID: 35853783
An introduction to the WHO 5th edition 2022 classification of testicular tumours.
Berney DM, Cree I, Rao V, Moch H, Srigley JR, Tsuzuki T, Amin MB, Comperat EM, Hartmann A, Menon S, Netto GJ, Rubin MA, Turajlic S, Raspollini MR, Tickoo SK
Histopathology 2022 Oct;81(4):459-466. Epub 2022 Jul 1 doi: 10.1111/his.14675. PMID: 35502823Free PMC Article
Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Testicular cancer.
Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, Looijenga LHJ
Nat Rev Dis Primers 2018 Oct 5;4(1):29. doi: 10.1038/s41572-018-0029-0. PMID: 30291251
Idiopathic granulomatous orchitis.
Roy S, Hooda S, Parwani AV
Pathol Res Pract 2011 May 15;207(5):275-8. Epub 2011 Apr 1 doi: 10.1016/j.prp.2011.02.005. PMID: 21458170

Therapy

Pathologic findings and clinical outcomes in patients who required neoadjuvant chemotherapy before orchiectomy for testicular germ cell tumors.
Stump JA, Acosta AM, Whaley RD, Cheng L, Fang AM, Rais-Bahrami S, Gordetsky JB
Hum Pathol 2022 Oct;128:48-55. Epub 2022 Jul 9 doi: 10.1016/j.humpath.2022.06.026. PMID: 35817140
The relationship between testicular tumour characteristics and azoospermia: a systematic review.
Pang KH, Osman NI, Muneer A, Alnajjar HM
Int J Impot Res 2022 Sep;34(6):543-551. Epub 2021 Nov 6 doi: 10.1038/s41443-021-00492-x. PMID: 34743192
Current knowledge of risk factors for testicular germ cell tumors.
Fukawa T, Kanayama HO
Int J Urol 2018 Apr;25(4):337-344. Epub 2018 Jan 17 doi: 10.1111/iju.13519. PMID: 29345008
Postchemotherapy changes in testicular germ cell tumours: biology and morphology.
Berney DM, Lu YJ, Shamash J, Idrees M
Histopathology 2017 Jan;70(1):26-39. doi: 10.1111/his.13078. PMID: 27960240
Long-Term Follow-Up after Treatment of Cryptorchidism.
Thorup J, Cortes D
Eur J Pediatr Surg 2016 Oct;26(5):427-431. Epub 2016 Sep 2 doi: 10.1055/s-0036-1592138. PMID: 27589079

Prognosis

An introduction to the WHO 5th edition 2022 classification of testicular tumours.
Berney DM, Cree I, Rao V, Moch H, Srigley JR, Tsuzuki T, Amin MB, Comperat EM, Hartmann A, Menon S, Netto GJ, Rubin MA, Turajlic S, Raspollini MR, Tickoo SK
Histopathology 2022 Oct;81(4):459-466. Epub 2022 Jul 1 doi: 10.1111/his.14675. PMID: 35502823Free PMC Article
Testicular cancer.
Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, Looijenga LHJ
Nat Rev Dis Primers 2018 Oct 5;4(1):29. doi: 10.1038/s41572-018-0029-0. PMID: 30291251
Perspectives on testicular germ cell neoplasms.
Cheng L, Lyu B, Roth LM
Hum Pathol 2017 Jan;59:10-25. Epub 2016 Aug 26 doi: 10.1016/j.humpath.2016.08.002. PMID: 27569298
Long-Term Follow-Up after Treatment of Cryptorchidism.
Thorup J, Cortes D
Eur J Pediatr Surg 2016 Oct;26(5):427-431. Epub 2016 Sep 2 doi: 10.1055/s-0036-1592138. PMID: 27589079
Intratubular Germ Cell Neoplasia of the Testis, Bilateral Testicular Cancer, and Aberrant Histologies.
Sharma P, Dhillon J, Sexton WJ
Urol Clin North Am 2015 Aug;42(3):277-85. Epub 2015 Jun 6 doi: 10.1016/j.ucl.2015.04.002. PMID: 26216815

Clinical prediction guides

Application of miRNAs in the diagnosis and monitoring of testicular germ cell tumours.
Almstrup K, Lobo J, Mørup N, Belge G, Rajpert-De Meyts E, Looijenga LHJ, Dieckmann KP
Nat Rev Urol 2020 Apr;17(4):201-213. Epub 2020 Mar 10 doi: 10.1038/s41585-020-0296-x. PMID: 32157202
Perspectives on testicular germ cell neoplasms.
Cheng L, Lyu B, Roth LM
Hum Pathol 2017 Jan;59:10-25. Epub 2016 Aug 26 doi: 10.1016/j.humpath.2016.08.002. PMID: 27569298
Germ cell neoplasia in situ (GCNIS): evolution of the current nomenclature for testicular pre-invasive germ cell malignancy.
Berney DM, Looijenga LH, Idrees M, Oosterhuis JW, Rajpert-De Meyts E, Ulbright TM, Skakkebaek NE
Histopathology 2016 Jul;69(1):7-10. Epub 2016 Apr 12 doi: 10.1111/his.12958. PMID: 26918959
Gonadal maldevelopment as risk factor for germ cell cancer: towards a clinical decision model.
van der Zwan YG, Biermann K, Wolffenbuttel KP, Cools M, Looijenga LH
Eur Urol 2015 Apr;67(4):692-701. Epub 2014 Sep 18 doi: 10.1016/j.eururo.2014.07.011. PMID: 25240975
Difficult differential diagnoses in testicular pathology.
Ye H, Ulbright TM
Arch Pathol Lab Med 2012 Apr;136(4):435-46. doi: 10.5858/arpa.2011-0475-RA. PMID: 22458906

Recent systematic reviews

Testis-sparing Surgery in Adult Patients with Germ Cell Tumors: Systematic Search of the Literature and Focused Review.
Heidenreich A, Seelemeyer F, Altay B, Laguna MP
Eur Urol Focus 2023 Mar;9(2):244-247. Epub 2022 Nov 21 doi: 10.1016/j.euf.2022.11.001. PMID: 36418210
Oncological and functional outcomes after testis-sparing surgery in patients with germ cell tumors: a systematic review of 285 cases.
Grogg JB, Dursun ZH, Beyer J, Eberli D, Poyet C, Hermanns T, Fankhauser CD
World J Urol 2022 Sep;40(9):2293-2303. Epub 2022 Jul 12 doi: 10.1007/s00345-022-04048-6. PMID: 35821265Free PMC Article
The relationship between testicular tumour characteristics and azoospermia: a systematic review.
Pang KH, Osman NI, Muneer A, Alnajjar HM
Int J Impot Res 2022 Sep;34(6):543-551. Epub 2021 Nov 6 doi: 10.1038/s41443-021-00492-x. PMID: 34743192
Diagnosis and Management of Intratubular Germ Cell Neoplasia In Situ: A Systematic Review.
Gupta M, Cheaib JG, Patel HD, Sharma R, Zhang A, Bass EB, Pierorazio PM
J Urol 2020 Jul;204(1):33-41. Epub 2020 Jan 22 doi: 10.1097/JU.0000000000000758. PMID: 31967523
Germ Cell Tumors in Dysgenetic Gonads.
Piazza MJ, Urbanetz AA
Clinics (Sao Paulo) 2019;74:e408. Epub 2019 Nov 11 doi: 10.6061/clinics/2019/e408. PMID: 31721911Free PMC Article

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