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Decreased circulating complement C9 concentration

MedGen UID:: 866744
•Concept ID:: C4021093
•: Finding

Synonyms:	Decreased serum C9; Decreased serum complement C9

HPO:	HP:0012308

Definition

Concentration of the complement component C9 in the blood circulation below the lower limit of normal. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVDecreased circulating complement C9 concentration

Abnormality of the immune system
- Abnormality of immune system physiology
  - Abnormality of humoral immunity
    - Abnormality of complement system
      - Reduced circulating complement concentration
        Decreased circulating terminal complement component concentration
        Decreased circulating complement C9 concentration

Conditions with this feature

Complement component 9 deficiency

MedGen UID:: 462539
•Concept ID:: C3151189
•: Disease or Syndrome

Any classic complement early component deficiency in which the cause of the disease is a mutation in the C9 gene.

See: Condition Record

Complement component 9 deficiency

Recent clinical studies

Etiology

Proteomic analysis of intraluminal thrombus highlights complement activation in human abdominal aortic aneurysms.

Martinez-Pinna R, Madrigal-Matute J, Tarin C, Burillo E, Esteban-Salan M, Pastor-Vargas C, Lindholt JS, Lopez JA, Calvo E, de Ceniga MV, Meilhac O, Egido J, Blanco-Colio LM, Michel JB, Martin-Ventura JL
Arterioscler Thromb Vasc Biol 2013 Aug;33(8):2013-20. Epub 2013 May 23 doi: 10.1161/ATVBAHA.112.301191. PMID: 23702661

Immunological evaluation of late complement component-deficient individuals.

Platonov AE, Beloborodov VB, Gabrilovitch DI, Khabarova VV, Serebrovskaya LV
Clin Immunol Immunopathol 1992 Aug;64(2):98-105. doi: 10.1016/0090-1229(92)90186-r. PMID: 1643749

Clinical prediction guides

Proteomic analysis of intraluminal thrombus highlights complement activation in human abdominal aortic aneurysms.

Martinez-Pinna R, Madrigal-Matute J, Tarin C, Burillo E, Esteban-Salan M, Pastor-Vargas C, Lindholt JS, Lopez JA, Calvo E, de Ceniga MV, Meilhac O, Egido J, Blanco-Colio LM, Michel JB, Martin-Ventura JL
Arterioscler Thromb Vasc Biol 2013 Aug;33(8):2013-20. Epub 2013 May 23 doi: 10.1161/ATVBAHA.112.301191. PMID: 23702661

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Decreased circulating complement C9 concentration
Decreased circulating complement C9 concentration

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C4021093[conceptid] (1)
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