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Abnormality of humoral immunity

MedGen UID:
461860
Concept ID:
C3150510
Finding
Synonym: Defective humoral immunity
 
HPO: HP:0005368

Definition

An abnormality of the humoral immune system, which comprises antibodies produced by B cells as well as the complement system. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormality of humoral immunity

Professional guidelines

PubMed

Li SB, Xiong Y, Han XR, Liu ZY, Lv XL, Ning P
Breastfeed Med 2021 Sep;16(9):759-764. Epub 2021 Apr 19 doi: 10.1089/bfm.2021.0023. PMID: 33872053
Chang C, Tanaka A, Bowlus C, Gershwin ME
Expert Opin Investig Drugs 2020 Apr;29(4):385-398. Epub 2020 Feb 26 doi: 10.1080/13543784.2020.1733527. PMID: 32102572
Righi E
World J Gastroenterol 2018 Oct 14;24(38):4311-4329. doi: 10.3748/wjg.v24.i38.4311. PMID: 30344417Free PMC Article

Recent clinical studies

Etiology

Xu J, Wang BY, Yu SH, Chen SJ, Yang SS, Liu R, Chen LJ, Hou J, Chen Z, Zhao WH, He AL, Mi JQ, Chen SJ
J Hematol Oncol 2024 Apr 24;17(1):23. doi: 10.1186/s13045-024-01530-z. PMID: 38659046Free PMC Article
Bonvalet M, Ollila HM, Ambati A, Mignot E
Curr Opin Pulm Med 2017 Nov;23(6):522-529. doi: 10.1097/MCP.0000000000000426. PMID: 28991006Free PMC Article
Christiansen OB
Mol Immunol 2013 Aug;55(1):8-15. Epub 2012 Oct 9 doi: 10.1016/j.molimm.2012.08.025. PMID: 23062611
Hovdenak N, Haram K
Eur J Obstet Gynecol Reprod Biol 2012 Oct;164(2):127-32. Epub 2012 Jul 6 doi: 10.1016/j.ejogrb.2012.06.020. PMID: 22771225
Trence DL, Morley JE, Handwerger BS
Am J Med 1984 Jul;77(1):107-16. doi: 10.1016/0002-9343(84)90444-3. PMID: 6377888

Diagnosis

Boivin-Jahns V, Jahns R
Front Biosci (Landmark Ed) 2018 Jun 1;23(11):2065-2081. doi: 10.2741/4690. PMID: 29772546
Bonvalet M, Ollila HM, Ambati A, Mignot E
Curr Opin Pulm Med 2017 Nov;23(6):522-529. doi: 10.1097/MCP.0000000000000426. PMID: 28991006Free PMC Article
Lakshminarayanan B, Davenport M
J Autoimmun 2016 Sep;73:1-9. Epub 2016 Jun 23 doi: 10.1016/j.jaut.2016.06.005. PMID: 27346637
Lambert N, Strebel P, Orenstein W, Icenogle J, Poland GA
Lancet 2015 Jun 6;385(9984):2297-307. Epub 2015 Jan 8 doi: 10.1016/S0140-6736(14)60539-0. PMID: 25576992Free PMC Article
Le Poole C, Boissy RE
Semin Cutan Med Surg 1997 Mar;16(1):3-14. doi: 10.1016/s1085-5629(97)80030-2. PMID: 9125760

Therapy

Barmada A, Klein J, Ramaswamy A, Brodsky NN, Jaycox JR, Sheikha H, Jones KM, Habet V, Campbell M, Sumida TS, Kontorovich A, Bogunovic D, Oliveira CR, Steele J, Hall EK, Pena-Hernandez M, Monteiro V, Lucas C, Ring AM, Omer SB, Iwasaki A, Yildirim I, Lucas CL
Sci Immunol 2023 May 12;8(83):eadh3455. Epub 2023 May 5 doi: 10.1126/sciimmunol.adh3455. PMID: 37146127Free PMC Article
Bonvalet M, Ollila HM, Ambati A, Mignot E
Curr Opin Pulm Med 2017 Nov;23(6):522-529. doi: 10.1097/MCP.0000000000000426. PMID: 28991006Free PMC Article
Lakshminarayanan B, Davenport M
J Autoimmun 2016 Sep;73:1-9. Epub 2016 Jun 23 doi: 10.1016/j.jaut.2016.06.005. PMID: 27346637
Lambert N, Strebel P, Orenstein W, Icenogle J, Poland GA
Lancet 2015 Jun 6;385(9984):2297-307. Epub 2015 Jan 8 doi: 10.1016/S0140-6736(14)60539-0. PMID: 25576992Free PMC Article
Hovdenak N, Haram K
Eur J Obstet Gynecol Reprod Biol 2012 Oct;164(2):127-32. Epub 2012 Jul 6 doi: 10.1016/j.ejogrb.2012.06.020. PMID: 22771225

Prognosis

Xu J, Wang BY, Yu SH, Chen SJ, Yang SS, Liu R, Chen LJ, Hou J, Chen Z, Zhao WH, He AL, Mi JQ, Chen SJ
J Hematol Oncol 2024 Apr 24;17(1):23. doi: 10.1186/s13045-024-01530-z. PMID: 38659046Free PMC Article
Pecorelli A, Cervellati C, Cordone V, Hayek J, Valacchi G
Free Radic Biol Med 2020 May 20;152:100-106. Epub 2020 Feb 28 doi: 10.1016/j.freeradbiomed.2020.02.023. PMID: 32119978
Lakshminarayanan B, Davenport M
J Autoimmun 2016 Sep;73:1-9. Epub 2016 Jun 23 doi: 10.1016/j.jaut.2016.06.005. PMID: 27346637
Singhal S, Mehta J
Clin J Am Soc Nephrol 2006 Nov;1(6):1322-30. Epub 2006 Oct 11 doi: 10.2215/CJN.03060906. PMID: 17699365
Trence DL, Morley JE, Handwerger BS
Am J Med 1984 Jul;77(1):107-16. doi: 10.1016/0002-9343(84)90444-3. PMID: 6377888

Clinical prediction guides

Xu J, Wang BY, Yu SH, Chen SJ, Yang SS, Liu R, Chen LJ, Hou J, Chen Z, Zhao WH, He AL, Mi JQ, Chen SJ
J Hematol Oncol 2024 Apr 24;17(1):23. doi: 10.1186/s13045-024-01530-z. PMID: 38659046Free PMC Article
Shilova N, Huflejt ME, Vuskovic M, Obukhova P, Navakouski M, Khasbiullina N, Pazynina G, Galanina O, Bazhenov A, Bovin N
Top Curr Chem 2015;366:169-81. doi: 10.1007/128_2013_469. PMID: 24037491
Singhal S, Mehta J
Clin J Am Soc Nephrol 2006 Nov;1(6):1322-30. Epub 2006 Oct 11 doi: 10.2215/CJN.03060906. PMID: 17699365
Le Poole C, Boissy RE
Semin Cutan Med Surg 1997 Mar;16(1):3-14. doi: 10.1016/s1085-5629(97)80030-2. PMID: 9125760
Trence DL, Morley JE, Handwerger BS
Am J Med 1984 Jul;77(1):107-16. doi: 10.1016/0002-9343(84)90444-3. PMID: 6377888

Recent systematic reviews

Lam JN, Nehira J, Phung O, Deng B
J Pharm Pract 2024 Aug;37(4):967-976. Epub 2023 Aug 22 doi: 10.1177/08971900231196065. PMID: 37605626
Meyerowitz EA, Sen P, Schoenfeld SR, Neilan TG, Frigault MJ, Stone JH, Kim AY, Mansour MK
Clin Infect Dis 2021 Jun 15;72(12):e1130-e1143. doi: 10.1093/cid/ciaa1759. PMID: 33216852Free PMC Article
Grywalska E, Zaborek M, Łyczba J, Hrynkiewicz R, Bębnowska D, Becht R, Sosnowska-Pasiarska B, Smok-Kalwat J, Pasiarski M, Góźdź S, Roliński J, Niedźwiedzka-Rystwej P
Cells 2020 Nov 2;9(11) doi: 10.3390/cells9112398. PMID: 33147729Free PMC Article
Flateau C, Le Loup G, Pialoux G
Lancet Infect Dis 2011 Jul;11(7):541-56. doi: 10.1016/S1473-3099(11)70031-7. PMID: 21700241

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