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Abnormality of humoral immunity

MedGen UID:
461860
•Concept ID:
C3150510
•
Finding
Synonym: Defective humoral immunity
 
HPO: HP:0005368

Definition

An abnormality of the humoral immune system, which comprises antibodies produced by B cells as well as the complement system. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormality of humoral immunity

Professional guidelines

PubMed

Pregnancy Associated Granulomatous Mastitis: Clinical Characteristics, Management, and Outcome.
Li SB, Xiong Y, Han XR, Liu ZY, Lv XL, Ning P
Breastfeed Med 2021 Sep;16(9):759-764. Epub 2021 Apr 19 doi: 10.1089/bfm.2021.0023. PMID: 33872053
The use of biologics in the treatment of autoimmune liver disease.
Chang C, Tanaka A, Bowlus C, Gershwin ME
Expert Opin Investig Drugs 2020 Apr;29(4):385-398. Epub 2020 Feb 26 doi: 10.1080/13543784.2020.1733527. PMID: 32102572
Management of bacterial and fungal infections in end stage liver disease and liver transplantation: Current options and future directions.
Righi E
World J Gastroenterol 2018 Oct 14;24(38):4311-4329. doi: 10.3748/wjg.v24.i38.4311. PMID: 30344417Free PMC Article

Recent clinical studies

Etiology

Autoimmunity in narcolepsy.
Bonvalet M, Ollila HM, Ambati A, Mignot E
Curr Opin Pulm Med 2017 Nov;23(6):522-529. doi: 10.1097/MCP.0000000000000426. PMID: 28991006Free PMC Article
Natural Antibodies Against Sialoglycans.
Shilova N, Huflejt ME, Vuskovic M, Obukhova P, Navakouski M, Khasbiullina N, Pazynina G, Galanina O, Bazhenov A, Bovin N
Top Curr Chem 2015;366:169-81. doi: 10.1007/128_2013_469. PMID: 24037491
Reproductive immunology.
Christiansen OB
Mol Immunol 2013 Aug;55(1):8-15. Epub 2012 Oct 9 doi: 10.1016/j.molimm.2012.08.025. PMID: 23062611
Influence of mineral and vitamin supplements on pregnancy outcome.
Hovdenak N, Haram K
Eur J Obstet Gynecol Reprod Biol 2012 Oct;164(2):127-32. Epub 2012 Jul 6 doi: 10.1016/j.ejogrb.2012.06.020. PMID: 22771225
Polyglandular autoimmune syndromes.
Trence DL, Morley JE, Handwerger BS
Am J Med 1984 Jul;77(1):107-16. doi: 10.1016/0002-9343(84)90444-3. PMID: 6377888

Diagnosis

GPCR-autoantibodies in chronic heart failure.
Boivin-Jahns V, Jahns R
Front Biosci (Landmark Ed) 2018 Jun 1;23(11):2065-2081. doi: 10.2741/4690. PMID: 29772546
Autoimmunity in narcolepsy.
Bonvalet M, Ollila HM, Ambati A, Mignot E
Curr Opin Pulm Med 2017 Nov;23(6):522-529. doi: 10.1097/MCP.0000000000000426. PMID: 28991006Free PMC Article
Biliary atresia: A comprehensive review.
Lakshminarayanan B, Davenport M
J Autoimmun 2016 Sep;73:1-9. Epub 2016 Jun 23 doi: 10.1016/j.jaut.2016.06.005. PMID: 27346637
Rubella.
Lambert N, Strebel P, Orenstein W, Icenogle J, Poland GA
Lancet 2015 Jun 6;385(9984):2297-307. Epub 2015 Jan 8 doi: 10.1016/S0140-6736(14)60539-0. PMID: 25576992Free PMC Article
Vitiligo.
Le Poole C, Boissy RE
Semin Cutan Med Surg 1997 Mar;16(1):3-14. doi: 10.1016/s1085-5629(97)80030-2. PMID: 9125760

Therapy

Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine-associated myocarditis.
Barmada A, Klein J, Ramaswamy A, Brodsky NN, Jaycox JR, Sheikha H, Jones KM, Habet V, Campbell M, Sumida TS, Kontorovich A, Bogunovic D, Oliveira CR, Steele J, Hall EK, Pena-Hernandez M, Monteiro V, Lucas C, Ring AM, Omer SB, Iwasaki A, Yildirim I, Lucas CL
Sci Immunol 2023 May 12;8(83):eadh3455. Epub 2023 May 5 doi: 10.1126/sciimmunol.adh3455. PMID: 37146127Free PMC Article
Autoimmunity in narcolepsy.
Bonvalet M, Ollila HM, Ambati A, Mignot E
Curr Opin Pulm Med 2017 Nov;23(6):522-529. doi: 10.1097/MCP.0000000000000426. PMID: 28991006Free PMC Article
Biliary atresia: A comprehensive review.
Lakshminarayanan B, Davenport M
J Autoimmun 2016 Sep;73:1-9. Epub 2016 Jun 23 doi: 10.1016/j.jaut.2016.06.005. PMID: 27346637
Rubella.
Lambert N, Strebel P, Orenstein W, Icenogle J, Poland GA
Lancet 2015 Jun 6;385(9984):2297-307. Epub 2015 Jan 8 doi: 10.1016/S0140-6736(14)60539-0. PMID: 25576992Free PMC Article
Influence of mineral and vitamin supplements on pregnancy outcome.
Hovdenak N, Haram K
Eur J Obstet Gynecol Reprod Biol 2012 Oct;164(2):127-32. Epub 2012 Jul 6 doi: 10.1016/j.ejogrb.2012.06.020. PMID: 22771225

Prognosis

Long-term remission and survival in patients with relapsed or refractory multiple myeloma after treatment with LCAR-B38M CAR T cells: 5-year follow-up of the LEGEND-2 trial.
Xu J, Wang BY, Yu SH, Chen SJ, Yang SS, Liu R, Chen LJ, Hou J, Chen Z, Zhao WH, He AL, Mi JQ, Chen SJ
J Hematol Oncol 2024 Apr 24;17(1):23. doi: 10.1186/s13045-024-01530-z. PMID: 38659046Free PMC Article
Compromised immune/inflammatory responses in Rett syndrome.
Pecorelli A, Cervellati C, Cordone V, Hayek J, Valacchi G
Free Radic Biol Med 2020 May 20;152:100-106. Epub 2020 Feb 28 doi: 10.1016/j.freeradbiomed.2020.02.023. PMID: 32119978
Biliary atresia: A comprehensive review.
Lakshminarayanan B, Davenport M
J Autoimmun 2016 Sep;73:1-9. Epub 2016 Jun 23 doi: 10.1016/j.jaut.2016.06.005. PMID: 27346637
Multiple myeloma.
Singhal S, Mehta J
Clin J Am Soc Nephrol 2006 Nov;1(6):1322-30. Epub 2006 Oct 11 doi: 10.2215/CJN.03060906. PMID: 17699365
Polyglandular autoimmune syndromes.
Trence DL, Morley JE, Handwerger BS
Am J Med 1984 Jul;77(1):107-16. doi: 10.1016/0002-9343(84)90444-3. PMID: 6377888

Clinical prediction guides

Long-term remission and survival in patients with relapsed or refractory multiple myeloma after treatment with LCAR-B38M CAR T cells: 5-year follow-up of the LEGEND-2 trial.
Xu J, Wang BY, Yu SH, Chen SJ, Yang SS, Liu R, Chen LJ, Hou J, Chen Z, Zhao WH, He AL, Mi JQ, Chen SJ
J Hematol Oncol 2024 Apr 24;17(1):23. doi: 10.1186/s13045-024-01530-z. PMID: 38659046Free PMC Article
Natural Antibodies Against Sialoglycans.
Shilova N, Huflejt ME, Vuskovic M, Obukhova P, Navakouski M, Khasbiullina N, Pazynina G, Galanina O, Bazhenov A, Bovin N
Top Curr Chem 2015;366:169-81. doi: 10.1007/128_2013_469. PMID: 24037491
Multiple myeloma.
Singhal S, Mehta J
Clin J Am Soc Nephrol 2006 Nov;1(6):1322-30. Epub 2006 Oct 11 doi: 10.2215/CJN.03060906. PMID: 17699365
Vitiligo.
Le Poole C, Boissy RE
Semin Cutan Med Surg 1997 Mar;16(1):3-14. doi: 10.1016/s1085-5629(97)80030-2. PMID: 9125760
Polyglandular autoimmune syndromes.
Trence DL, Morley JE, Handwerger BS
Am J Med 1984 Jul;77(1):107-16. doi: 10.1016/0002-9343(84)90444-3. PMID: 6377888

Recent systematic reviews

Systematic Review: Safety and Efficacy of mRNA COVID-19 Vaccines in Pregnant Women.
Lam JN, Nehira J, Phung O, Deng B
J Pharm Pract 2024 Aug;37(4):967-976. Epub 2023 Aug 22 doi: 10.1177/08971900231196065. PMID: 37605626
Immunomodulation as Treatment for Severe Coronavirus Disease 2019: A Systematic Review of Current Modalities and Future Directions.
Meyerowitz EA, Sen P, Schoenfeld SR, Neilan TG, Frigault MJ, Stone JH, Kim AY, Mansour MK
Clin Infect Dis 2021 Jun 15;72(12):e1130-e1143. doi: 10.1093/cid/ciaa1759. PMID: 33216852Free PMC Article
Chronic Lymphocytic Leukemia-Induced Humoral Immunosuppression: A Systematic Review.
Grywalska E, Zaborek M, Łyczba J, Hrynkiewicz R, Bębnowska D, Becht R, Sosnowska-Pasiarska B, Smok-Kalwat J, Pasiarski M, Góźdź S, Roliński J, Niedźwiedzka-Rystwej P
Cells 2020 Nov 2;9(11) doi: 10.3390/cells9112398. PMID: 33147729Free PMC Article
Consequences of HIV infection on malaria and therapeutic implications: a systematic review.
Flateau C, Le Loup G, Pialoux G
Lancet Infect Dis 2011 Jul;11(7):541-56. doi: 10.1016/S1473-3099(11)70031-7. PMID: 21700241

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