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Pneumonitis

MedGen UID:
811420
•Concept ID:
C3714636
•
Disease or Syndrome
Synonyms: Inflammation, Lung; Inflammation, Pulmonary; Inflammations, Lung; Inflammations, Pulmonary; Lung Inflammation; Lung Inflammations; Pneumonitides; Pulmonary Inflammation; Pulmonary Inflammations
SNOMED CT: Pneumonitis (205237003)
 
Monarch Initiative: MONDO:0043905

Definition

An inflammatory process affecting the lung parenchyma. It is a milder form of lung inflammation compared to pneumonia. [from NCI]

Professional guidelines

PubMed

Diagnosis of Hypersensitivity Pneumonitis in Adults. An Official ATS/JRS/ALAT Clinical Practice Guideline.
Raghu G, Remy-Jardin M, Ryerson CJ, Myers JL, Kreuter M, Vasakova M, Bargagli E, Chung JH, Collins BF, Bendstrup E, Chami HA, Chua AT, Corte TJ, Dalphin JC, Danoff SK, Diaz-Mendoza J, Duggal A, Egashira R, Ewing T, Gulati M, Inoue Y, Jenkins AR, Johannson KA, Johkoh T, Tamae-Kakazu M, Kitaichi M, Knight SL, Koschel D, Lederer DJ, Mageto Y, Maier LA, Matiz C, Morell F, Nicholson AG, Patolia S, Pereira CA, Renzoni EA, Salisbury ML, Selman M, Walsh SLF, Wuyts WA, Wilson KC
Am J Respir Crit Care Med 2020 Aug 1;202(3):e36-e69. doi: 10.1164/rccm.202005-2032ST. PMID: 32706311Free PMC Article
Immune-Related Adverse Events (irAEs): Diagnosis, Management, and Clinical Pearls.
Darnell EP, Mooradian MJ, Baruch EN, Yilmaz M, Reynolds KL
Curr Oncol Rep 2020 Mar 21;22(4):39. doi: 10.1007/s11912-020-0897-9. PMID: 32200442
Radiation-Induced Lung Injury: Assessment and Management.
Hanania AN, Mainwaring W, Ghebre YT, Hanania NA, Ludwig M
Chest 2019 Jul;156(1):150-162. Epub 2019 Apr 15 doi: 10.1016/j.chest.2019.03.033. PMID: 30998908Free PMC Article

Recent clinical studies

Etiology

Inhalational lung diseases.
Prieto Fernandez A, Palomo Antequera B, Del Castillo Arango K, Blanco Guindel M, Nava Tomas ME, Mesa Alvarez AM
Radiologia (Engl Ed) 2022 Dec;64 Suppl 3:290-300. doi: 10.1016/j.rxeng.2022.10.007. PMID: 36737167
Pooled analysis of drug-related interstitial lung disease and/or pneumonitis in nine trastuzumab deruxtecan monotherapy studies.
Powell CA, Modi S, Iwata H, Takahashi S, Smit EF, Siena S, Chang DY, Macpherson E, Qin A, Singh J, Taitt C, Shire N, Camidge DR
ESMO Open 2022 Aug;7(4):100554. Epub 2022 Aug 11 doi: 10.1016/j.esmoop.2022.100554. PMID: 35963179Free PMC Article
Steroid-refractory PD-(L)1 pneumonitis: incidence, clinical features, treatment, and outcomes.
Balaji A, Hsu M, Lin CT, Feliciano J, Marrone K, Brahmer JR, Forde PM, Hann C, Zheng L, Lee V, Illei PB, Danoff SK, Suresh K, Naidoo J
J Immunother Cancer 2021 Jan;9(1) doi: 10.1136/jitc-2020-001731. PMID: 33414264Free PMC Article
Immune Checkpoint Inhibitor-Related Pneumonitis.
Gomatou G, Tzilas V, Kotteas E, Syrigos K, Bouros D
Respiration 2020;99(11):932-942. Epub 2020 Dec 1 doi: 10.1159/000509941. PMID: 33260191
Radiation-Induced Lung Injury: Assessment and Management.
Hanania AN, Mainwaring W, Ghebre YT, Hanania NA, Ludwig M
Chest 2019 Jul;156(1):150-162. Epub 2019 Apr 15 doi: 10.1016/j.chest.2019.03.033. PMID: 30998908Free PMC Article

Diagnosis

Hypersensitivity pneumonitis: new concepts and classifications.
Churg A
Mod Pathol 2022 Jan;35(Suppl 1):15-27. Epub 2021 Sep 16 doi: 10.1038/s41379-021-00866-y. PMID: 34531525
Radiation-induced lung injury: current evidence.
Arroyo-Hernández M, Maldonado F, Lozano-Ruiz F, Muñoz-Montaño W, Nuñez-Baez M, Arrieta O
BMC Pulm Med 2021 Jan 6;21(1):9. doi: 10.1186/s12890-020-01376-4. PMID: 33407290Free PMC Article
Immune Checkpoint Inhibitor-Related Pneumonitis.
Gomatou G, Tzilas V, Kotteas E, Syrigos K, Bouros D
Respiration 2020;99(11):932-942. Epub 2020 Dec 1 doi: 10.1159/000509941. PMID: 33260191
Radiation-Induced Lung Injury: Assessment and Management.
Hanania AN, Mainwaring W, Ghebre YT, Hanania NA, Ludwig M
Chest 2019 Jul;156(1):150-162. Epub 2019 Apr 15 doi: 10.1016/j.chest.2019.03.033. PMID: 30998908Free PMC Article
Radiation Pneumonitis.
Bledsoe TJ, Nath SK, Decker RH
Clin Chest Med 2017 Jun;38(2):201-208. Epub 2017 Mar 1 doi: 10.1016/j.ccm.2016.12.004. PMID: 28477633

Therapy

Optimizing treatment management of trastuzumab deruxtecan in clinical practice of breast cancer.
Rugo HS, Bianchini G, Cortes J, Henning JW, Untch M
ESMO Open 2022 Aug;7(4):100553. Epub 2022 Aug 11 doi: 10.1016/j.esmoop.2022.100553. PMID: 35964548Free PMC Article
Trastuzumab deruxtecan for HER2+ advanced breast cancer.
Lee J, Park YH
Future Oncol 2022 Jan;18(1):7-19. Epub 2021 Nov 26 doi: 10.2217/fon-2021-0550. PMID: 34823373
Adjuvant Nivolumab versus Placebo in Muscle-Invasive Urothelial Carcinoma.
Bajorin DF, Witjes JA, Gschwend JE, Schenker M, Valderrama BP, Tomita Y, Bamias A, Lebret T, Shariat SF, Park SH, Ye D, Agerbaek M, Enting D, McDermott R, Gajate P, Peer A, Milowsky MI, Nosov A, Neif Antonio J Jr, Tupikowski K, Toms L, Fischer BS, Qureshi A, Collette S, Unsal-Kacmaz K, Broughton E, Zardavas D, Koon HB, Galsky MD
N Engl J Med 2021 Jun 3;384(22):2102-2114. doi: 10.1056/NEJMoa2034442. PMID: 34077643Free PMC Article
Efficacy and Safety of Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib: The CheckMate 040 Randomized Clinical Trial.
Yau T, Kang YK, Kim TY, El-Khoueiry AB, Santoro A, Sangro B, Melero I, Kudo M, Hou MM, Matilla A, Tovoli F, Knox JJ, Ruth He A, El-Rayes BF, Acosta-Rivera M, Lim HY, Neely J, Shen Y, Wisniewski T, Anderson J, Hsu C
JAMA Oncol 2020 Nov 1;6(11):e204564. Epub 2020 Nov 12 doi: 10.1001/jamaoncol.2020.4564. PMID: 33001135Free PMC Article
Tumour- and class-specific patterns of immune-related adverse events of immune checkpoint inhibitors: a systematic review.
Khoja L, Day D, Wei-Wu Chen T, Siu LL, Hansen AR
Ann Oncol 2017 Oct 1;28(10):2377-2385. doi: 10.1093/annonc/mdx286. PMID: 28945858

Prognosis

Aspiration syndromes and associated lung injury: incidence, pathophysiology and management.
Košutova P, Mikolka P
Physiol Res 2021 Dec 30;70(Suppl4):S567-S583. doi: 10.33549/physiolres.934767. PMID: 35199544Free PMC Article
COVID-19 Legacy.
Ladani AP, Loganathan M, Kolikonda MK, Lippmann S
South Med J 2021 Dec;114(12):751-759. doi: 10.14423/SMJ.0000000000001337. PMID: 34853850Free PMC Article
Steroid-refractory PD-(L)1 pneumonitis: incidence, clinical features, treatment, and outcomes.
Balaji A, Hsu M, Lin CT, Feliciano J, Marrone K, Brahmer JR, Forde PM, Hann C, Zheng L, Lee V, Illei PB, Danoff SK, Suresh K, Naidoo J
J Immunother Cancer 2021 Jan;9(1) doi: 10.1136/jitc-2020-001731. PMID: 33414264Free PMC Article
Hypersensitivity pneumonitis.
Costabel U, Miyazaki Y, Pardo A, Koschel D, Bonella F, Spagnolo P, Guzman J, Ryerson CJ, Selman M
Nat Rev Dis Primers 2020 Aug 6;6(1):65. doi: 10.1038/s41572-020-0191-z. PMID: 32764620
Concurrent once-daily versus twice-daily chemoradiotherapy in patients with limited-stage small-cell lung cancer (CONVERT): an open-label, phase 3, randomised, superiority trial.
Faivre-Finn C, Snee M, Ashcroft L, Appel W, Barlesi F, Bhatnagar A, Bezjak A, Cardenal F, Fournel P, Harden S, Le Pechoux C, McMenemin R, Mohammed N, O'Brien M, Pantarotto J, Surmont V, Van Meerbeeck JP, Woll PJ, Lorigan P, Blackhall F; CONVERT Study Team
Lancet Oncol 2017 Aug;18(8):1116-1125. Epub 2017 Jun 20 doi: 10.1016/S1470-2045(17)30318-2. PMID: 28642008Free PMC Article

Clinical prediction guides

Radiation-induced lung injury: current evidence.
Arroyo-Hernández M, Maldonado F, Lozano-Ruiz F, Muñoz-Montaño W, Nuñez-Baez M, Arrieta O
BMC Pulm Med 2021 Jan 6;21(1):9. doi: 10.1186/s12890-020-01376-4. PMID: 33407290Free PMC Article
Radiation-induced lung toxicity - cellular and molecular mechanisms of pathogenesis, management, and literature review.
Käsmann L, Dietrich A, Staab-Weijnitz CA, Manapov F, Behr J, Rimner A, Jeremic B, Senan S, De Ruysscher D, Lauber K, Belka C
Radiat Oncol 2020 Sep 10;15(1):214. doi: 10.1186/s13014-020-01654-9. PMID: 32912295Free PMC Article
Presentation, diagnosis and clinical course of the spectrum of progressive-fibrosing interstitial lung diseases.
Cottin V, Hirani NA, Hotchkin DL, Nambiar AM, Ogura T, Otaola M, Skowasch D, Park JS, Poonyagariyagorn HK, Wuyts W, Wells AU
Eur Respir Rev 2018 Dec 31;27(150) Epub 2018 Dec 21 doi: 10.1183/16000617.0076-2018. PMID: 30578335Free PMC Article
Pulmonary manifestations of Sjögren's syndrome.
Flament T, Bigot A, Chaigne B, Henique H, Diot E, Marchand-Adam S
Eur Respir Rev 2016 Jun;25(140):110-23. doi: 10.1183/16000617.0011-2016. PMID: 27246587Free PMC Article
Prediction of postoperative pulmonary complications in a population-based surgical cohort.
Canet J, Gallart L, Gomar C, Paluzie G, Vallès J, Castillo J, Sabaté S, Mazo V, Briones Z, Sanchis J; ARISCAT Group
Anesthesiology 2010 Dec;113(6):1338-50. doi: 10.1097/ALN.0b013e3181fc6e0a. PMID: 21045639

Recent systematic reviews

Stereotactic body radiotherapy for Ultra-Central lung Tumors: A systematic review and Meta-Analysis and International Stereotactic Radiosurgery Society practice guidelines.
Yan M, Louie AV, Kotecha R, Ashfaq Ahmed M, Zhang Z, Guckenberger M, Kim MS, Lo SS, Scorsetti M, Tree AC, Sahgal A, Slotman BJ
Lung Cancer 2023 Aug;182:107281. Epub 2023 Jun 21 doi: 10.1016/j.lungcan.2023.107281. PMID: 37393758
Comparative safety of immune checkpoint inhibitors in cancer: systematic review and network meta-analysis.
Xu C, Chen YP, Du XJ, Liu JQ, Huang CL, Chen L, Zhou GQ, Li WF, Mao YP, Hsu C, Liu Q, Lin AH, Tang LL, Sun Y, Ma J
BMJ 2018 Nov 8;363:k4226. doi: 10.1136/bmj.k4226. PMID: 30409774Free PMC Article
Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-analysis.
Wang DY, Salem JE, Cohen JV, Chandra S, Menzer C, Ye F, Zhao S, Das S, Beckermann KE, Ha L, Rathmell WK, Ancell KK, Balko JM, Bowman C, Davis EJ, Chism DD, Horn L, Long GV, Carlino MS, Lebrun-Vignes B, Eroglu Z, Hassel JC, Menzies AM, Sosman JA, Sullivan RJ, Moslehi JJ, Johnson DB
JAMA Oncol 2018 Dec 1;4(12):1721-1728. doi: 10.1001/jamaoncol.2018.3923. PMID: 30242316Free PMC Article
Immune-related adverse events for anti-PD-1 and anti-PD-L1 drugs: systematic review and meta-analysis.
Baxi S, Yang A, Gennarelli RL, Khan N, Wang Z, Boyce L, Korenstein D
BMJ 2018 Mar 14;360:k793. doi: 10.1136/bmj.k793. PMID: 29540345Free PMC Article
Tumour- and class-specific patterns of immune-related adverse events of immune checkpoint inhibitors: a systematic review.
Khoja L, Day D, Wei-Wu Chen T, Siu LL, Hansen AR
Ann Oncol 2017 Oct 1;28(10):2377-2385. doi: 10.1093/annonc/mdx286. PMID: 28945858

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