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Primary Cutaneous Mucinous Carcinoma

MedGen UID:
362690
•Concept ID:
C1879641
•
Neoplastic Process
Synonyms: Adnexal Mucinous Adenocarcinoma; Adnexal Mucinous Carcinoma; Sweat Gland Mucinous Carcinoma

Definition

A rare low-grade carcinoma of the sweat glands. The most common sites are eyelids, scalp, axilla, face and trunk. It is histologically characterized by proliferating ducts until the overproduction of mucin creates islands of tumor cells, essentially floating in mucinous pools (Rosai J. Ackerman''s Surgical Pathology). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrimary Cutaneous Mucinous Carcinoma

Professional guidelines

PubMed

Primary Cutaneous Mucinous Carcinoma: A Review of the Literature.
Freeman T, Russell AJ, Council ML
Dermatol Surg 2023 Dec 1;49(12):1091-1095. Epub 2023 Aug 29 doi: 10.1097/DSS.0000000000003921. PMID: 37643246
Prognostic Factors, Treatment, and Survival in Primary Cutaneous Mucinous Carcinoma: A SEER Database Analysis.
Rismiller KP, Crowe DR, Knackstedt TJ
Dermatol Surg 2020 Sep;46(9):1141-1147. doi: 10.1097/DSS.0000000000002263. PMID: 31702595

Recent clinical studies

Etiology

Cutaneous Neuroendocrine Mucinous Carcinomas Are Low-grade But May Be Associated With Other Cancers.
Adkins KE, Busam K, Pulitzer M
Am J Surg Pathol 2023 Oct 1;47(10):1186-1191. Epub 2023 Aug 3 doi: 10.1097/PAS.0000000000002107. PMID: 37530225Free PMC Article
Prognostic Factors, Treatment, and Survival in Primary Cutaneous Mucinous Carcinoma: A SEER Database Analysis.
Rismiller KP, Crowe DR, Knackstedt TJ
Dermatol Surg 2020 Sep;46(9):1141-1147. doi: 10.1097/DSS.0000000000002263. PMID: 31702595
Renal Cell Carcinoma Antigen Expression in Primary Cutaneous Endocrine Mucinous Carcinomas: A Case Series of 14 Patients and Review of the Literature.
Ansari AN, Bobos M, Shih S, Chen MC, Ardakani NM, Rosales CM, Chen CJ, Savage C, Bracey T, McKee PH, Cerruto CA
Am J Dermatopathol 2019 Aug;41(8):571-577. doi: 10.1097/DAD.0000000000001370. PMID: 31335409
Primary cutaneous mucinous carcinoma: a systematic review and meta-analysis of outcomes after surgery.
Kamalpour L, Brindise RT, Nodzenski M, Bach DQ, Veledar E, Alam M
JAMA Dermatol 2014 Apr;150(4):380-4. doi: 10.1001/jamadermatol.2013.6006. PMID: 24452370
Immunohistochemical stains in Mohs surgery: a review.
Stranahan D, Cherpelis BS, Glass LF, Ladd S, Fenske NA
Dermatol Surg 2009 Jul;35(7):1023-34. Epub 2009 Apr 16 doi: 10.1111/j.1524-4725.2009.01179.x. PMID: 19397647

Diagnosis

Endocrine Mucin-Producing Sweat Gland Carcinoma and Primary Cutaneous Mucinous Carcinoma: A Case Series.
Grushchak S, Barlow T, Palla B, Mannor GE, Greenway HT, Kelley BF
Cutis 2023 Sep;112(3):E6-E10. doi: 10.12788/cutis.0856. PMID: 37903397
Primary Cutaneous Mucinous Carcinoma: A Review of the Literature.
Freeman T, Russell AJ, Council ML
Dermatol Surg 2023 Dec 1;49(12):1091-1095. Epub 2023 Aug 29 doi: 10.1097/DSS.0000000000003921. PMID: 37643246
Double Primary Malignancies Involving Cutaneous Carcinoma.
Sung KY, Lee S, Lee SY
J Craniofac Surg 2022 Nov-Dec 01;33(8):e806-e808. Epub 2022 Jun 29 doi: 10.1097/SCS.0000000000008672. PMID: 36409851
Renal Cell Carcinoma Antigen Expression in Primary Cutaneous Endocrine Mucinous Carcinomas: A Case Series of 14 Patients and Review of the Literature.
Ansari AN, Bobos M, Shih S, Chen MC, Ardakani NM, Rosales CM, Chen CJ, Savage C, Bracey T, McKee PH, Cerruto CA
Am J Dermatopathol 2019 Aug;41(8):571-577. doi: 10.1097/DAD.0000000000001370. PMID: 31335409
Malignant sweat gland tumours: an update.
Cardoso JC, Calonje E
Histopathology 2015 Nov;67(5):589-606. Epub 2015 Jul 21 doi: 10.1111/his.12767. PMID: 26114606

Therapy

Mohs micrographic surgery for the treatment of primary cutaneous mucinous carcinoma.
Kelly Á, Anand R, Natkunarajah J, Samarasinghe V, Craythorne E
Clin Exp Dermatol 2023 Jul 7;48(7):778-780. doi: 10.1093/ced/llad057. PMID: 36787279
Expression of hormone receptors, adipophilin, and GCDFP-15 in mucinous carcinoma of the skin.
Sung YN, Park CS, Roh J, Choi JW, Choi SH, Lee Y, Cho KJ
J Cutan Pathol 2018 Dec;45(12):886-890. Epub 2018 Oct 4 doi: 10.1111/cup.13349. PMID: 30178542
Cutaneous mucinous carcinoma arising in extramammary Paget disease of the perineum.
Matin RN, Gibbon K, Rizvi H, Harwood CA, Cerio R
Am J Dermatopathol 2011 Oct;33(7):705-9. doi: 10.1097/DAD.0b013e3181f9c83d. PMID: 21885944

Prognosis

Primary Cutaneous Mucinous Carcinoma: A Review of the Literature.
Freeman T, Russell AJ, Council ML
Dermatol Surg 2023 Dec 1;49(12):1091-1095. Epub 2023 Aug 29 doi: 10.1097/DSS.0000000000003921. PMID: 37643246
Cutaneous Neuroendocrine Mucinous Carcinomas Are Low-grade But May Be Associated With Other Cancers.
Adkins KE, Busam K, Pulitzer M
Am J Surg Pathol 2023 Oct 1;47(10):1186-1191. Epub 2023 Aug 3 doi: 10.1097/PAS.0000000000002107. PMID: 37530225Free PMC Article
Prognostic Factors, Treatment, and Survival in Primary Cutaneous Mucinous Carcinoma: A SEER Database Analysis.
Rismiller KP, Crowe DR, Knackstedt TJ
Dermatol Surg 2020 Sep;46(9):1141-1147. doi: 10.1097/DSS.0000000000002263. PMID: 31702595
Renal Cell Carcinoma Antigen Expression in Primary Cutaneous Endocrine Mucinous Carcinomas: A Case Series of 14 Patients and Review of the Literature.
Ansari AN, Bobos M, Shih S, Chen MC, Ardakani NM, Rosales CM, Chen CJ, Savage C, Bracey T, McKee PH, Cerruto CA
Am J Dermatopathol 2019 Aug;41(8):571-577. doi: 10.1097/DAD.0000000000001370. PMID: 31335409
Primary cutaneous mucinous carcinoma: a systematic review and meta-analysis of outcomes after surgery.
Kamalpour L, Brindise RT, Nodzenski M, Bach DQ, Veledar E, Alam M
JAMA Dermatol 2014 Apr;150(4):380-4. doi: 10.1001/jamadermatol.2013.6006. PMID: 24452370

Clinical prediction guides

Analysis of Head and Neck Primary Cutaneous Mucinous Carcinoma: An Indolent Tumor of the Eccrine Sweat Glands.
Behbahani S, Pinto JO, Wassef D, Povolotskiy R, Paskhover B
J Craniofac Surg 2021 May 1;32(3):e244-e247. doi: 10.1097/SCS.0000000000006968. PMID: 32890173
Renal Cell Carcinoma Antigen Expression in Primary Cutaneous Endocrine Mucinous Carcinomas: A Case Series of 14 Patients and Review of the Literature.
Ansari AN, Bobos M, Shih S, Chen MC, Ardakani NM, Rosales CM, Chen CJ, Savage C, Bracey T, McKee PH, Cerruto CA
Am J Dermatopathol 2019 Aug;41(8):571-577. doi: 10.1097/DAD.0000000000001370. PMID: 31335409
Expression of hormone receptors, adipophilin, and GCDFP-15 in mucinous carcinoma of the skin.
Sung YN, Park CS, Roh J, Choi JW, Choi SH, Lee Y, Cho KJ
J Cutan Pathol 2018 Dec;45(12):886-890. Epub 2018 Oct 4 doi: 10.1111/cup.13349. PMID: 30178542
Primary cutaneous mucinous carcinoma: a systematic review and meta-analysis of outcomes after surgery.
Kamalpour L, Brindise RT, Nodzenski M, Bach DQ, Veledar E, Alam M
JAMA Dermatol 2014 Apr;150(4):380-4. doi: 10.1001/jamadermatol.2013.6006. PMID: 24452370
Primary cutaneous mucinous carcinoma of the cheek. Case report.
Scilletta A, Soma PF, Grasso G, Scilletta R, Pompili G, Tarico MS, Perrotta RE
G Chir 2011 Jun-Jul;32(6-7):323-5. PMID: 21771401

Recent systematic reviews

Primary cutaneous mucinous carcinoma: a systematic review and meta-analysis of outcomes after surgery.
Kamalpour L, Brindise RT, Nodzenski M, Bach DQ, Veledar E, Alam M
JAMA Dermatol 2014 Apr;150(4):380-4. doi: 10.1001/jamadermatol.2013.6006. PMID: 24452370

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