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Acute myeloblastic leukemia with maturation

MedGen UID:
361829
Concept ID:
C1879321
Neoplastic Process
Synonym: Acute myeloid leukemia with maturation
SNOMED CT: Acute myeloid leukemia with maturation (103691009); Acute myeloblastic leukemia with maturation (103691009); Acute granulocytic leukemia with maturation (103691009); Acute myelogenous leukemia with maturation (103691009); Acute myelocytic leukemia with maturation (103691009); FAB M2 (103691009); M2 - Acute myeloblastic leukemia with maturation (359648001); Acute myeloid leukemia with maturation, FAB M2 (359648001)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0020320
Orphanet: ORPHA98834

Definition

A rare, acute myeloid leukemia characterized by evidence of granulocytic maturation and more than 20% of blast cells in the bone marrow and/or peripheral blood. The maturing non-blast granulocytic cells account for greater than or equal to 10% and monocytic cells less than or equal to 20% of the bone marrow cells. Various degrees of anemia, thrombocytopenia, or pancytopenia are present. Frequent clinical manifestations include fatigue, fever, bleeding disorders, and organomegaly, especially hepatosplenomegaly. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Acute myeloblastic leukemia with maturation

Professional guidelines

PubMed

Garcia-Manero G
Am J Hematol 2023 Aug;98(8):1307-1325. Epub 2023 Jun 8 doi: 10.1002/ajh.26984. PMID: 37288607
Shimony S, Stahl M, Stone RM
Am J Hematol 2023 Mar;98(3):502-526. Epub 2023 Jan 13 doi: 10.1002/ajh.26822. PMID: 36594187
Sekeres MA, Taylor J
JAMA 2022 Sep 6;328(9):872-880. doi: 10.1001/jama.2022.14578. PMID: 36066514

Recent clinical studies

Etiology

Zeremski V, Savić A
Med Pregl 2014 Mar-Apr;67(3-4):83-90. PMID: 24961049

Diagnosis

Consoli ML, Romano A, Parrinello NL, Tambè L, Romeo MA, Salemi D, Santoro A, DI Raimondo F
Anticancer Res 2019 Aug;39(8):4329-4332. doi: 10.21873/anticanres.13599. PMID: 31366525
Gmidène A, Frikha R, Sennana H, Elghezal H, Elloumi M, Saad A
Med Oncol 2011 Dec;28 Suppl 1:S509-12. Epub 2010 Oct 14 doi: 10.1007/s12032-010-9703-0. PMID: 20949334
Lu G, Yin CC, Medeiros LJ, Abruzzo LV
Cancer Genet Cytogenet 2009 Jan 15;188(2):118-23. doi: 10.1016/j.cancergencyto.2008.09.006. PMID: 19100517
Wong KF, Kwong YL, So CC
Cancer Genet Cytogenet 1998 Feb;101(1):39-41. doi: 10.1016/s0165-4608(97)00033-2. PMID: 9460498
Dalton WT Jr, Ahearn MJ, McCredie KB, Freireich EJ, Stass SA, Trujillo JM
Blood 1988 Jan;71(1):242-7. PMID: 3422031

Therapy

Zeremski V, Savić A
Med Pregl 2014 Mar-Apr;67(3-4):83-90. PMID: 24961049
Rowley JD
Ann Clin Lab Sci 1983 Mar-Apr;13(2):87-94. PMID: 6602585

Prognosis

Zeremski V, Savić A
Med Pregl 2014 Mar-Apr;67(3-4):83-90. PMID: 24961049
Lu G, Yin CC, Medeiros LJ, Abruzzo LV
Cancer Genet Cytogenet 2009 Jan 15;188(2):118-23. doi: 10.1016/j.cancergencyto.2008.09.006. PMID: 19100517
Berger R, Bernheim A, Daniel MT, Valensi F, Sigaux F, Flandrin G
Blood 1982 Jan;59(1):171-8. PMID: 6947830

Clinical prediction guides

Fujita N, Shimazaki C, Murakami S, Oku N, Itoh K, Takeda N, Nakanishi S, Haruyama H, Nishio A, Nakagawa M
Acta Haematol 1990;84(1):45-8. doi: 10.1159/000205027. PMID: 2117329
Rowley JD
Ann Clin Lab Sci 1983 Mar-Apr;13(2):87-94. PMID: 6602585
Berger R, Bernheim A, Daniel MT, Valensi F, Sigaux F, Flandrin G
Blood 1982 Jan;59(1):171-8. PMID: 6947830

Supplemental Content

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