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Adult myxoid chondrosarcoma

MedGen UID:
312875
•Concept ID:
C1706731
•
Neoplastic Process
Synonyms: Adult Extraosseous Myxoid Chondrosarcoma; Adult Extraskeletal Myxoid Chondrosarcoma; Adult Myxoid Chondrosarcoma; adult myxoid chondrosarcoma; myxoid chondrosarcoma of adults
 
Monarch Initiative: MONDO:0003899

Definition

An extraskeletal myxoid chondrosarcoma occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult myxoid chondrosarcoma

Professional guidelines

PubMed

Differential diagnosis of myxoid soft tissue tumors. Experience in the Clinical University Hospital of Valencia.
Alfaro-Cervelló C, Nieto G, Navarro S
Rev Esp Patol 2022 Jul-Sep;55(3):185-191. Epub 2019 Nov 4 doi: 10.1016/j.patol.2019.07.005. PMID: 35779885
Prognostic Factors and Treatment Options for Patients with High-Grade Chondrosarcoma.
Gao Z, Lu T, Song H, Gao Z, Ren F, Ouyang P, Wang Y, Zhu J, Zhou S, He X
Med Sci Monit 2019 Nov 25;25:8952-8967. doi: 10.12659/MSM.917959. PMID: 31765367Free PMC Article
The value of fine-needle aspiration biopsy in the differential diagnosis of adult myxoid sarcoma.
Kilpatrick SE, Ward WG, Bos GD
Cancer 2000 Jun 25;90(3):167-77. doi: 10.1002/1097-0142(20000625)90:3<167::aid-cncr5>3.0.co;2-z. PMID: 10896330

Recent clinical studies

Etiology

Extraskeletal myxoid chondrosarcoma: Clinical features and overall survival.
Brown JM, Rakoczy K, Pretell-Mazzini J
Cancer Treat Res Commun 2022;31:100530. Epub 2022 Feb 5 doi: 10.1016/j.ctarc.2022.100530. PMID: 35144048
INSM1 Expression in Chordomas.
Dridi M, Boutonnat J, Dumollard JM, Peoc'h M, Karpathiou G
Am J Clin Pathol 2021 Aug 4;156(3):334-339. doi: 10.1093/ajcp/aqaa250. PMID: 33629710
Sarcoma Stem Cell Heterogeneity.
Hatina J, Kripnerova M, Houfkova K, Pesta M, Kuncova J, Sana J, Slaby O, Rodríguez R
Adv Exp Med Biol 2019;1123:95-118. doi: 10.1007/978-3-030-11096-3_7. PMID: 31016597
Emerging therapies for adult soft tissue sarcoma.
Radaelli S, Stacchiotti S, Casali PG, Gronchi A
Expert Rev Anticancer Ther 2014 Jun;14(6):689-704. Epub 2014 Feb 20 doi: 10.1586/14737140.2014.885840. PMID: 24555529
Extraskeletal myxoid chondrosarcoma.
McGrory JE, Rock MG, Nascimento AG, Oliveira AM
Clin Orthop Relat Res 2001 Jan;(382):185-90. doi: 10.1097/00003086-200101000-00025. PMID: 11153986

Diagnosis

Expanding the Spectrum of NR4A3 Fusion-Positive Gynecologic Leiomyosarcomas.
Momeni-Boroujeni A, Mullaney K, DiNapoli SE, Leitao MM Jr, Hensley ML, Katabi N, Allison DHR, Park KJ, Antonescu CR, Chiang S
Mod Pathol 2024 May;37(5):100474. Epub 2024 Mar 18 doi: 10.1016/j.modpat.2024.100474. PMID: 38508521
PRAME immunohistochemistry in soft tissue tumors and mimics: a study of 350 cases highlighting its imperfect specificity but potentially useful diagnostic applications.
Cammareri C, Beltzung F, Michal M, Vanhersecke L, Coindre JM, Velasco V, Le Loarer F, Vergier B, Perret R
Virchows Arch 2023 Aug;483(2):145-156. Epub 2023 Jul 21 doi: 10.1007/s00428-023-03606-6. PMID: 37477762
Extraskeletal myxoid chondrosarcoma: Clinical features and overall survival.
Brown JM, Rakoczy K, Pretell-Mazzini J
Cancer Treat Res Commun 2022;31:100530. Epub 2022 Feb 5 doi: 10.1016/j.ctarc.2022.100530. PMID: 35144048
INSM1 Expression in Chordomas.
Dridi M, Boutonnat J, Dumollard JM, Peoc'h M, Karpathiou G
Am J Clin Pathol 2021 Aug 4;156(3):334-339. doi: 10.1093/ajcp/aqaa250. PMID: 33629710
Extra-axial chordoma.
DiFrancesco LM, Davanzo Castillo CA, Temple WJ
Arch Pathol Lab Med 2006 Dec;130(12):1871-4. doi: 10.5858/2006-130-1871-EC. PMID: 17149966

Therapy

Pazopanib for treatment of advanced extraskeletal myxoid chondrosarcoma: a multicentre, single-arm, phase 2 trial.
Stacchiotti S, Ferrari S, Redondo A, Hindi N, Palmerini E, Vaz Salgado MA, Frezza AM, Casali PG, Gutierrez A, Lopez-Pousa A, Grignani G, Italiano A, LeCesne A, Dumont S, Blay JY, Penel N, Bernabeu D, de Alava E, Karanian M, Morosi C, Brich S, Dagrada GP, Vallacchi V, Castelli C, Brenca M, Racanelli D, Maestro R, Collini P, Cruz J, Martin-Broto J
Lancet Oncol 2019 Sep;20(9):1252-1262. Epub 2019 Jul 19 doi: 10.1016/S1470-2045(19)30319-5. PMID: 31331701
Clinical benefit of antiangiogenic therapy in advanced and metastatic chondrosarcoma.
Jones RL, Katz D, Loggers ET, Davidson D, Rodler ET, Pollack SM
Med Oncol 2017 Aug 29;34(10):167. doi: 10.1007/s12032-017-1030-2. PMID: 28852958Free PMC Article
Activity of sunitinib in extraskeletal myxoid chondrosarcoma.
Stacchiotti S, Pantaleo MA, Astolfi A, Dagrada GP, Negri T, Dei Tos AP, Indio V, Morosi C, Gronchi A, Colombo C, Conca E, Toffolatti L, Tazzari M, Crippa F, Maestro R, Pilotti S, Casali PG
Eur J Cancer 2014 Jun;50(9):1657-64. Epub 2014 Apr 2 doi: 10.1016/j.ejca.2014.03.013. PMID: 24703573
Emerging therapies for adult soft tissue sarcoma.
Radaelli S, Stacchiotti S, Casali PG, Gronchi A
Expert Rev Anticancer Ther 2014 Jun;14(6):689-704. Epub 2014 Feb 20 doi: 10.1586/14737140.2014.885840. PMID: 24555529
Correlation between clinicopathological features and karyotype in 100 cartilaginous and chordoid tumours. A report from the Chromosomes and Morphology (CHAMP) Collaborative Study Group.
Tallini G, Dorfman H, Brys P, Dal Cin P, De Wever I, Fletcher CD, Jonson K, Mandahl N, Mertens F, Mitelman F, Rosai J, Rydholm A, Samson I, Sciot R, Van den Berghe H, Vanni R, Willén H
J Pathol 2002 Feb;196(2):194-203. doi: 10.1002/path.1023. PMID: 11793371

Prognosis

Surgical outcomes of extraskeletal myxoid chondrosarcoma.
Ulucaköy C, Atalay İB, Yapar A, Kaptan AY, Bingöl İ, Doğan M, Ekşioğlu MF
Turk J Med Sci 2022 Aug;52(4):1183-1189. Epub 2022 Aug 10 doi: 10.55730/1300-0144.5422. PMID: 36326382Free PMC Article
Extraskeletal myxoid chondrosarcoma: Clinical features and overall survival.
Brown JM, Rakoczy K, Pretell-Mazzini J
Cancer Treat Res Commun 2022;31:100530. Epub 2022 Feb 5 doi: 10.1016/j.ctarc.2022.100530. PMID: 35144048
Survival and Prognosis of Chondrosarcoma Subtypes: SEER Database Analysis.
Amer KM, Munn M, Congiusta D, Abraham JA, Basu Mallick A
J Orthop Res 2020 Feb;38(2):311-319. Epub 2019 Sep 22 doi: 10.1002/jor.24463. PMID: 31498474
Extra-axial chordoma.
DiFrancesco LM, Davanzo Castillo CA, Temple WJ
Arch Pathol Lab Med 2006 Dec;130(12):1871-4. doi: 10.5858/2006-130-1871-EC. PMID: 17149966
Extraskeletal myxoid chondrosarcoma.
McGrory JE, Rock MG, Nascimento AG, Oliveira AM
Clin Orthop Relat Res 2001 Jan;(382):185-90. doi: 10.1097/00003086-200101000-00025. PMID: 11153986

Clinical prediction guides

Expanding the Spectrum of NR4A3 Fusion-Positive Gynecologic Leiomyosarcomas.
Momeni-Boroujeni A, Mullaney K, DiNapoli SE, Leitao MM Jr, Hensley ML, Katabi N, Allison DHR, Park KJ, Antonescu CR, Chiang S
Mod Pathol 2024 May;37(5):100474. Epub 2024 Mar 18 doi: 10.1016/j.modpat.2024.100474. PMID: 38508521
Extraskeletal myxoid chondrosarcoma: Clinicopathological features and outcomes from the United States sarcoma collaborative database.
Gusho CA, King D, Ethun CG, Cardona K, Harrison Howard J, Tran TB, Poultsides G, Tseng J, Roggin KK, Fields RC, Cullinan DR, Chouliaras K, Votanopoulos K, Grignol VP, Bedi M
J Surg Oncol 2022 Dec;126(8):1533-1542. Epub 2022 Aug 13 doi: 10.1002/jso.27062. PMID: 35962783
Extraskeletal myxoid chondrosarcoma: Clinical features and overall survival.
Brown JM, Rakoczy K, Pretell-Mazzini J
Cancer Treat Res Commun 2022;31:100530. Epub 2022 Feb 5 doi: 10.1016/j.ctarc.2022.100530. PMID: 35144048
Laryngeal Chondrosarcoma Characteristics and Survival Analysis in the National Cancer Database.
Talati VM, Urban MJ, Patel TR, Wojcik C, Tajudeen BA, Stenson K, Bhayani MK, Al-Khudari S, Husain IA
Otolaryngol Head Neck Surg 2022 Jan;166(1):101-108. Epub 2021 Apr 13 doi: 10.1177/01945998211004578. PMID: 33848444
Myxoid and round cell liposarcoma: a spectrum of myxoid adipocytic neoplasia.
Orvieto E, Furlanetto A, Laurino L, Dei Tos AP
Semin Diagn Pathol 2001 Nov;18(4):267-73. PMID: 11757867

Recent systematic reviews

Chondrosarcomas of the hands and feet: A case series and systematic review of the literature.
Fayad LM, Ahlawat S, Khan MS, McCarthy E
Eur J Radiol 2015 Oct;84(10):2004-12. Epub 2015 Jul 2 doi: 10.1016/j.ejrad.2015.06.026. PMID: 26189572

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