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Dentinogenic Ghost Cell Tumor

MedGen UID:
352813
•Concept ID:
C1704219
•
Neoplastic Process
Synonyms: Calcifying Ghost Cell Odontogenic Tumor; Dentinoameloblastoma; Dentinogenic ghost cell neoplasm; Dentinogenic ghost cell tumor; Dentinoma; Odontogenic ghost cell neoplasm; Odontogenic Ghost Cell Tumor; Odontogenic ghost cell tumor
SNOMED CT: Dentinogenic ghost cell tumor (788592003); Odontogenic ghost cell neoplasm (788592003); Dentinogenic ghost cell neoplasm (788592003); Odontogenic ghost cell tumor (788592003)

Definition

A benign but locally infiltrating neoplasm arising from tooth-forming tissues. It is more often intraosseous and less frequently extraosseous and occurs in the jaw. It is characterized by the presence of ameloblastoma-like epithelium, connective tissue stroma, ghost cells, and dysplastic dentin. Wide local resection is recommended for intraosseous neoplasms and enucleation for extraosseous neoplasms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDentinogenic Ghost Cell Tumor

Professional guidelines

PubMed

The diagnosis and treatment of dentinogenic ghost cell tumor.
Sun G, Huang X, Hu Q, Yang X, Tang E
Int J Oral Maxillofac Surg 2009 Nov;38(11):1179-83. Epub 2009 Jul 19 doi: 10.1016/j.ijom.2009.06.016. PMID: 19619984

Recent clinical studies

Etiology

Proceedings of the 2023 North American Society of Head and Neck Pathology Companion Meeting, New Orleans, LA, March 12, 2023: Odontogenic Tumors: Have We Achieved an Evidence-Based Classification.
Magliocca KR
Head Neck Pathol 2023 Jun;17(2):313-324. Epub 2023 Jun 6 doi: 10.1007/s12105-023-01561-x. PMID: 37278887Free PMC Article
Calcifying epithelial odontogenic cyst.
Manohar B, Baidya D, Shetty N, Mathur A, Makhijani B
J Exp Ther Oncol 2017 Nov;12(2):151-156. PMID: 29161784
Histologic Variants of Calcifying Odontogenic Cyst: A Study of 52 Cases.
Irani S, Foroughi F
J Contemp Dent Pract 2017 Aug 1;18(8):688-694. doi: 10.5005/jp-journals-10024-2108. PMID: 28816191
Central Dentinogenic Ghost Cell Tumor: An Update on a Rare Aggressive Odontogenic Tumor.
Buchner A, Akrish SJ, Vered M
J Oral Maxillofac Surg 2016 Feb;74(2):307-14. Epub 2015 Aug 7 doi: 10.1016/j.joms.2015.08.001. PMID: 26341683
The diagnosis and treatment of dentinogenic ghost cell tumor.
Sun G, Huang X, Hu Q, Yang X, Tang E
Int J Oral Maxillofac Surg 2009 Nov;38(11):1179-83. Epub 2009 Jul 19 doi: 10.1016/j.ijom.2009.06.016. PMID: 19619984

Diagnosis

Dentinogenic ghost cell tumor: a case report and review of the literature.
Hammad Y, Bueno S, McLean-Holden A, Schlieve T
Oral Maxillofac Surg 2023 Mar;27(1):169-173. Epub 2022 Jan 31 doi: 10.1007/s10006-021-01034-x. PMID: 35098400
Recurrent Dentinogenic Ghost Cell Tumor: A Case Report.
Alzaid MA, Kavarodi AM, AlQahtani WM, AlJanobi HA
Am J Case Rep 2022 Aug 23;23:e936787. doi: 10.12659/AJCR.936787. PMID: 35996339Free PMC Article
Ghost cells unveiled: A comprehensive review.
Garg A, Malhotra R, Urs AB
J Oral Biosci 2022 Jun;64(2):202-209. Epub 2022 Apr 6 doi: 10.1016/j.job.2022.03.005. PMID: 35398253
Comparative Analysis Between Dentinogenic Ghost Cell Tumor and Ghost Cell Odontogenic Carcinoma: A Systematic Review.
de Souza Vieira G, de Pinho Montovani P, Rozza-de-Menezes RE, Cunha KSG, Conde DC
Head Neck Pathol 2021 Dec;15(4):1265-1283. Epub 2021 Jun 14 doi: 10.1007/s12105-021-01347-z. PMID: 34128137Free PMC Article
Ghost Cell Tumors.
Sheikh J, Cohen MD, Ramer N, Payami A
J Oral Maxillofac Surg 2017 Apr;75(4):750-758. Epub 2016 Oct 26 doi: 10.1016/j.joms.2016.10.013. PMID: 27865804

Prognosis

Ghost cells unveiled: A comprehensive review.
Garg A, Malhotra R, Urs AB
J Oral Biosci 2022 Jun;64(2):202-209. Epub 2022 Apr 6 doi: 10.1016/j.job.2022.03.005. PMID: 35398253
Comparative Analysis Between Dentinogenic Ghost Cell Tumor and Ghost Cell Odontogenic Carcinoma: A Systematic Review.
de Souza Vieira G, de Pinho Montovani P, Rozza-de-Menezes RE, Cunha KSG, Conde DC
Head Neck Pathol 2021 Dec;15(4):1265-1283. Epub 2021 Jun 14 doi: 10.1007/s12105-021-01347-z. PMID: 34128137Free PMC Article
Exophytic gingival growth of the maxillary canine region in a young individual: Extremely rare case report of peripheral dentinogenic ghost cell tumor.
Nahid R, Bansal M, Gupta K, Pandey S, Tiwari P, Agarwal R
J Cancer Res Ther 2020 Apr-Jun;16(3):661-664. doi: 10.4103/jcrt.JCRT_180_19. PMID: 32719286
Central Dentinogenic Ghost Cell Tumor: An Update on a Rare Aggressive Odontogenic Tumor.
Buchner A, Akrish SJ, Vered M
J Oral Maxillofac Surg 2016 Feb;74(2):307-14. Epub 2015 Aug 7 doi: 10.1016/j.joms.2015.08.001. PMID: 26341683
The diagnosis and treatment of dentinogenic ghost cell tumor.
Sun G, Huang X, Hu Q, Yang X, Tang E
Int J Oral Maxillofac Surg 2009 Nov;38(11):1179-83. Epub 2009 Jul 19 doi: 10.1016/j.ijom.2009.06.016. PMID: 19619984

Clinical prediction guides

Ghost cell odontogenic carcinoma arising in dentinogenic ghost cell tumor, peripheral: A case report.
Sakamoto S, Ando T, Mizuta K, Ono S, Konishi M, Miyauchi M, Ogawa I
Pathol Int 2023 Aug;73(8):367-372. Epub 2023 Jul 4 doi: 10.1111/pin.13351. PMID: 37401869
Peripheral Dentinogenic Ghost Cell Tumor of the Maxilla.
Altindis S, Tokuc B, Hosgor H, Coskunses FM
J Craniofac Surg 2021 Nov-Dec 01;32(8):e739-e740. doi: 10.1097/SCS.0000000000007719. PMID: 34183624
Peripheral dentinogenic ghost cell tumor-report of two cases and review of the literature.
da Silva Barros CC, de Souto Medeiros MR, de Azevedo RA, da Costa Miguel MC, Dos Santos JN, da Silveira ÉJD
Oral Maxillofac Surg 2021 Dec;25(4):575-579. Epub 2021 Feb 14 doi: 10.1007/s10006-021-00947-x. PMID: 33586115
Giant dentinogenic ghost cell tumor: A case report.
Soares CD, Carlos R, de Lima Morais TM, de Almeida OP
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Oct;126(4):e215-e219. Epub 2018 Apr 18 doi: 10.1016/j.oooo.2018.04.003. PMID: 29753697
Peripheral dentinogenic ghost cell tumor: a case report and review of the literature.
Candido GA, Viana KA, Watanabe S, Vencio EF
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009 Sep;108(3):e86-90. doi: 10.1016/j.tripleo.2009.04.033. PMID: 19716497

Recent systematic reviews

Comparative Analysis Between Dentinogenic Ghost Cell Tumor and Ghost Cell Odontogenic Carcinoma: A Systematic Review.
de Souza Vieira G, de Pinho Montovani P, Rozza-de-Menezes RE, Cunha KSG, Conde DC
Head Neck Pathol 2021 Dec;15(4):1265-1283. Epub 2021 Jun 14 doi: 10.1007/s12105-021-01347-z. PMID: 34128137Free PMC Article
Calcifying odontogenic cyst, dentinogenic ghost cell tumor, and ghost cell odontogenic carcinoma: A systematic review.
de Arruda JAA, Monteiro JLGC, Abreu LG, de Oliveira Silva LV, Schuch LF, de Noronha MS, Callou G, Moreno A, Mesquita RA
J Oral Pathol Med 2018 Sep;47(8):721-730. Epub 2018 May 25 doi: 10.1111/jop.12727. PMID: 29738629

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