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Phototoxicity

MedGen UID:
282896
•Concept ID:
C1527358
•
Disease or Syndrome
SNOMED CT: Phototoxicity (84326006)

Definition

A nonimmunologic, chemically induced type of photosensitivity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPhototoxicity

Professional guidelines

PubMed

Targeting the central melanocortin system for the treatment of metabolic disorders.
Sweeney P, Gimenez LE, Hernandez CC, Cone RD
Nat Rev Endocrinol 2023 Sep;19(9):507-519. Epub 2023 Jun 26 doi: 10.1038/s41574-023-00855-y. PMID: 37365323
Evidence-based consensus guidelines for the diagnosis and management of erythropoietic protoporphyria and X-linked protoporphyria.
Dickey AK, Naik H, Keel SB, Levy C, Beaven SW, Elmariah SB, Erwin AL, Goddu RJ, Hedstrom K, Leaf RK, Kazamel M, Mazepa M, Philpotts LL, Quigley J, Raef H, Rudnick SR, Saberi B, Thapar M, Ungar J, Wang B, Balwani M; Porphyrias Consortium of the Rare Diseases Clinical Research Network
J Am Acad Dermatol 2023 Dec;89(6):1227-1237. Epub 2022 Aug 27 doi: 10.1016/j.jaad.2022.08.036. PMID: 36041558Free PMC Article
Erythropoietic Protoporphyria and X-Linked Protoporphyria: pathophysiology, genetics, clinical manifestations, and management.
Balwani M
Mol Genet Metab 2019 Nov;128(3):298-303. Epub 2019 Jan 24 doi: 10.1016/j.ymgme.2019.01.020. PMID: 30704898Free PMC Article

Recent clinical studies

Etiology

Tetracyclines-An Important Therapeutic Tool for Dermatologists.
Orylska-Ratynska M, Placek W, Owczarczyk-Saczonek A
Int J Environ Res Public Health 2022 Jun 13;19(12) doi: 10.3390/ijerph19127246. PMID: 35742496Free PMC Article
Tattoo inks are toxicological risks to human health: A systematic review of their ingredients, fate inside skin, toxicity due to polycyclic aromatic hydrocarbons, primary aromatic amines, metals, and overview of regulatory frameworks.
Negi S, Bala L, Shukla S, Chopra D
Toxicol Ind Health 2022 Jul;38(7):417-434. Epub 2022 May 19 doi: 10.1177/07482337221100870. PMID: 35592919
RIFM low-exposure fragrance ingredients safety assessment.
Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA Jr, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S
Food Chem Toxicol 2021 Mar;149 Suppl 1:111981. Epub 2021 Feb 10 doi: 10.1016/j.fct.2021.111981. PMID: 33577945
Retinal injury from handheld lasers: a review.
Bhavsar KV, Michel Z, Greenwald M, Cunningham ET Jr,, Freund KB
Surv Ophthalmol 2021 Mar-Apr;66(2):231-260. Epub 2020 Jul 3 doi: 10.1016/j.survophthal.2020.06.006. PMID: 32628946
Mechanisms of blue light-induced eye hazard and protective measures: a review.
Ouyang X, Yang J, Hong Z, Wu Y, Xie Y, Wang G
Biomed Pharmacother 2020 Oct;130:110577. Epub 2020 Aug 4 doi: 10.1016/j.biopha.2020.110577. PMID: 32763817

Diagnosis

Evidence-based consensus guidelines for the diagnosis and management of erythropoietic protoporphyria and X-linked protoporphyria.
Dickey AK, Naik H, Keel SB, Levy C, Beaven SW, Elmariah SB, Erwin AL, Goddu RJ, Hedstrom K, Leaf RK, Kazamel M, Mazepa M, Philpotts LL, Quigley J, Raef H, Rudnick SR, Saberi B, Thapar M, Ungar J, Wang B, Balwani M; Porphyrias Consortium of the Rare Diseases Clinical Research Network
J Am Acad Dermatol 2023 Dec;89(6):1227-1237. Epub 2022 Aug 27 doi: 10.1016/j.jaad.2022.08.036. PMID: 36041558Free PMC Article
Photosensitizing drug reactions.
Montgomery S, Worswick S
Clin Dermatol 2022 Jan-Feb;40(1):57-63. Epub 2021 Aug 8 doi: 10.1016/j.clindermatol.2021.08.014. PMID: 35190066
Iterative tomography with digital adaptive optics permits hour-long intravital observation of 3D subcellular dynamics at millisecond scale.
Wu J, Lu Z, Jiang D, Guo Y, Qiao H, Zhang Y, Zhu T, Cai Y, Zhang X, Zhanghao K, Xie H, Yan T, Zhang G, Li X, Jiang Z, Lin X, Fang L, Zhou B, Xi P, Fan J, Yu L, Dai Q
Cell 2021 Jun 10;184(12):3318-3332.e17. Epub 2021 May 25 doi: 10.1016/j.cell.2021.04.029. PMID: 34038702
The effect of blue-light blocking spectacle lenses on visual performance, macular health and the sleep-wake cycle: a systematic review of the literature.
Lawrenson JG, Hull CC, Downie LE
Ophthalmic Physiol Opt 2017 Nov;37(6):644-654. doi: 10.1111/opo.12406. PMID: 29044670
Drug-induced photosensitivity.
Dawe RS, Ibbotson SH
Dermatol Clin 2014 Jul;32(3):363-8, ix. doi: 10.1016/j.det.2014.03.014. PMID: 24891058

Therapy

Dersimelagon in Erythropoietic Protoporphyrias.
Balwani M, Bonkovsky HL, Levy C, Anderson KE, Bissell DM, Parker C, Takahashi F, Desnick RJ, Belongie K; Endeavor Investigators
N Engl J Med 2023 Apr 13;388(15):1376-1385. doi: 10.1056/NEJMoa2208754. PMID: 37043653
Tattoo inks are toxicological risks to human health: A systematic review of their ingredients, fate inside skin, toxicity due to polycyclic aromatic hydrocarbons, primary aromatic amines, metals, and overview of regulatory frameworks.
Negi S, Bala L, Shukla S, Chopra D
Toxicol Ind Health 2022 Jul;38(7):417-434. Epub 2022 May 19 doi: 10.1177/07482337221100870. PMID: 35592919
Photosensitizing drug reactions.
Montgomery S, Worswick S
Clin Dermatol 2022 Jan-Feb;40(1):57-63. Epub 2021 Aug 8 doi: 10.1016/j.clindermatol.2021.08.014. PMID: 35190066
Mechanisms of blue light-induced eye hazard and protective measures: a review.
Ouyang X, Yang J, Hong Z, Wu Y, Xie Y, Wang G
Biomed Pharmacother 2020 Oct;130:110577. Epub 2020 Aug 4 doi: 10.1016/j.biopha.2020.110577. PMID: 32763817
The effect of blue-light blocking spectacle lenses on visual performance, macular health and the sleep-wake cycle: a systematic review of the literature.
Lawrenson JG, Hull CC, Downie LE
Ophthalmic Physiol Opt 2017 Nov;37(6):644-654. doi: 10.1111/opo.12406. PMID: 29044670

Prognosis

Let's shed light on photogenotoxicity.
Diniz RR, de Pádula M, de Souza AMT
Sci Total Environ 2024 Dec 1;954:176354. Epub 2024 Sep 19 doi: 10.1016/j.scitotenv.2024.176354. PMID: 39304165
Outer Foveal Microdefects.
Cohen SY, Mrejen S, Nghiem-Buffet S, Dubois L, Fajnkuchen F, Gaudric A
Ophthalmol Retina 2021 Jun;5(6):553-561. Epub 2020 Sep 30 doi: 10.1016/j.oret.2020.09.018. PMID: 33007522
Drug-induced photosensitivity.
Dawe RS, Ibbotson SH
Dermatol Clin 2014 Jul;32(3):363-8, ix. doi: 10.1016/j.det.2014.03.014. PMID: 24891058
Macular microholes.
Emerson GG, Spencer GR, Klein ML
Retina 2007 Jun;27(5):595-600. doi: 10.1097/01.iae.0000243068.68099.b4. PMID: 17558322
Antimicrobial photosensitive reactions.
Vassileva SG, Mateev G, Parish LC
Arch Intern Med 1998 Oct 12;158(18):1993-2000. doi: 10.1001/archinte.158.18.1993. PMID: 9778198

Clinical prediction guides

Anticancer treatments and photosensitivity.
Sibaud V
J Eur Acad Dermatol Venereol 2022 Jun;36 Suppl 6(Suppl 6):51-58. doi: 10.1111/jdv.18200. PMID: 35738806Free PMC Article
Iterative tomography with digital adaptive optics permits hour-long intravital observation of 3D subcellular dynamics at millisecond scale.
Wu J, Lu Z, Jiang D, Guo Y, Qiao H, Zhang Y, Zhu T, Cai Y, Zhang X, Zhanghao K, Xie H, Yan T, Zhang G, Li X, Jiang Z, Lin X, Fang L, Zhou B, Xi P, Fan J, Yu L, Dai Q
Cell 2021 Jun 10;184(12):3318-3332.e17. Epub 2021 May 25 doi: 10.1016/j.cell.2021.04.029. PMID: 34038702
Outer Foveal Microdefects.
Cohen SY, Mrejen S, Nghiem-Buffet S, Dubois L, Fajnkuchen F, Gaudric A
Ophthalmol Retina 2021 Jun;5(6):553-561. Epub 2020 Sep 30 doi: 10.1016/j.oret.2020.09.018. PMID: 33007522
The effect of blue-light blocking spectacle lenses on visual performance, macular health and the sleep-wake cycle: a systematic review of the literature.
Lawrenson JG, Hull CC, Downie LE
Ophthalmic Physiol Opt 2017 Nov;37(6):644-654. doi: 10.1111/opo.12406. PMID: 29044670
Tracking cancer drugs in living cells by thermal profiling of the proteome.
Savitski MM, Reinhard FB, Franken H, Werner T, Savitski MF, Eberhard D, Martinez Molina D, Jafari R, Dovega RB, Klaeger S, Kuster B, Nordlund P, Bantscheff M, Drewes G
Science 2014 Oct 3;346(6205):1255784. Epub 2014 Oct 2 doi: 10.1126/science.1255784. PMID: 25278616

Recent systematic reviews

The update and transport of aluminum nanoparticles in plants and their biochemical and molecular phototoxicity on plant growth and development: A systematic review.
Pokharel BR, Sheri V, Kumar M, Zhang Z, Zhang B
Environ Pollut 2024 Jan 1;340(Pt 1):122875. Epub 2023 Nov 4 doi: 10.1016/j.envpol.2023.122875. PMID: 37931678
Tattoo inks are toxicological risks to human health: A systematic review of their ingredients, fate inside skin, toxicity due to polycyclic aromatic hydrocarbons, primary aromatic amines, metals, and overview of regulatory frameworks.
Negi S, Bala L, Shukla S, Chopra D
Toxicol Ind Health 2022 Jul;38(7):417-434. Epub 2022 May 19 doi: 10.1177/07482337221100870. PMID: 35592919
Blue light filtering ophthalmic lenses: A systematic review.
Vagge A, Ferro Desideri L, Del Noce C, Di Mola I, Sindaco D, Traverso CE
Semin Ophthalmol 2021 Oct 3;36(7):541-548. Epub 2021 Mar 18 doi: 10.1080/08820538.2021.1900283. PMID: 33734926
Drug-induced phototoxicity: A systematic review.
Kim WB, Shelley AJ, Novice K, Joo J, Lim HW, Glassman SJ
J Am Acad Dermatol 2018 Dec;79(6):1069-1075. Epub 2018 Jul 10 doi: 10.1016/j.jaad.2018.06.061. PMID: 30003982
The effect of blue-light blocking spectacle lenses on visual performance, macular health and the sleep-wake cycle: a systematic review of the literature.
Lawrenson JG, Hull CC, Downie LE
Ophthalmic Physiol Opt 2017 Nov;37(6):644-654. doi: 10.1111/opo.12406. PMID: 29044670

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