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Grade II meningioma

MedGen UID:: 307517
•Concept ID:: C1512259
•: Neoplastic Process

Synonyms:	Grade 2 Meningioma; grade 2 meningioma; Grade II Meningioma; grade II meningioma; WHO Grade 2 Meningioma; WHO Grade II Meningioma; WHO grade II meningioma

Monarch Initiative:	MONDO:0045056

Definition

An atypical meningioma which may recur in approximately 29-40% of the cases. This category includes the atypical meningioma, chordoid meningioma, and clear cell meningioma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVGrade II meningioma

Disorder by Site
- Disorder of nervous system
  - Disorder of the central nervous system
    - Neoplasm of the central nervous system
      - Benign neoplasm of the central nervous system
        Meningioma
        Grade II meningioma
        Adult Grade 2 Meningioma
        Adult Atypical Meningioma
        Atypical Meningioma
        Recurrent Atypical Meningioma
        Childhood Grade 2 Meningioma
        Chordoid meningioma
        Clear cell meningioma
        Brainstem intraparenchymal clear cell meningioma
        Spinal multifocal clear cell meningioma

Professional guidelines

PubMed

Treatment and follow-up results of WHO grade II meningiomas.

Güdük M, Ekşi MŞ, Bozkurt B, Usseli Mİ, Erşen Danyeli A, Pamir MN
J Clin Neurosci 2021 Sep;91:354-364. Epub 2021 Jul 30 doi: 10.1016/j.jocn.2021.07.022. PMID: 34373052

Recent advances in the management of atypical meningiomas.

Messerer M, Richoz B, Cossu G, Dhermain F, Hottinger AF, Parker F, Levivier M, Daniel RT
Neurochirurgie 2016 Aug;62(4):213-22. Epub 2016 Jun 28 doi: 10.1016/j.neuchi.2016.02.003. PMID: 27370103

An evidence-based treatment algorithm for the management of WHO Grade II and III meningiomas.

Sun SQ, Hawasli AH, Huang J, Chicoine MR, Kim AH
Neurosurg Focus 2015 Mar;38(3):E3. doi: 10.3171/2015.1.FOCUS14757. PMID: 25727225

See all (9)

Recent clinical studies

Etiology

Sporadic and neurofibromatosis type 2-associated meningioma in children and adolescents.

Wagener K, Beckhaus J, Boekhoff S, Friedrich C, Müller HL
J Neurooncol 2023 Jul;163(3):555-563. Epub 2023 Jul 4 doi: 10.1007/s11060-023-04344-0. PMID: 37402092

Treatment and follow-up results of WHO grade II meningiomas.

Güdük M, Ekşi MŞ, Bozkurt B, Usseli Mİ, Erşen Danyeli A, Pamir MN
J Clin Neurosci 2021 Sep;91:354-364. Epub 2021 Jul 30 doi: 10.1016/j.jocn.2021.07.022. PMID: 34373052

External beam radiation therapy for meningioma.

Chao S, Rogers L
Handb Clin Neurol 2020;170:259-278. doi: 10.1016/B978-0-12-822198-3.00046-X. PMID: 32586499

Intermediate-risk meningioma: initial outcomes from NRG Oncology RTOG 0539.

Rogers L, Zhang P, Vogelbaum MA, Perry A, Ashby LS, Modi JM, Alleman AM, Galvin J, Brachman D, Jenrette JM, De Groot J, Bovi JA, Werner-Wasik M, Knisely JPS, Mehta MP
J Neurosurg 2018 Jul;129(1):35-47. Epub 2017 Oct 6 doi: 10.3171/2016.11.JNS161170. PMID: 28984517 Free PMC Article

Adjuvant radiotherapy for atypical meningiomas.

Bagshaw HP, Burt LM, Jensen RL, Suneja G, Palmer CA, Couldwell WT, Shrieve DC
J Neurosurg 2017 Jun;126(6):1822-1828. Epub 2016 Sep 9 doi: 10.3171/2016.5.JNS152809. PMID: 27611201

See all (66)

Diagnosis

Sporadic and neurofibromatosis type 2-associated meningioma in children and adolescents.

Wagener K, Beckhaus J, Boekhoff S, Friedrich C, Müller HL
J Neurooncol 2023 Jul;163(3):555-563. Epub 2023 Jul 4 doi: 10.1007/s11060-023-04344-0. PMID: 37402092

Biomarkers for differentiating grade II meningiomas from grade I: a systematic review.

Sofela AA, McGavin L, Whitfield PC, Hanemann CO
Br J Neurosurg 2021 Dec;35(6):696-702. Epub 2021 Jun 21 doi: 10.1080/02688697.2021.1940853. PMID: 34148477

External beam radiation therapy for meningioma.

Chao S, Rogers L
Handb Clin Neurol 2020;170:259-278. doi: 10.1016/B978-0-12-822198-3.00046-X. PMID: 32586499

Intermediate-risk meningioma: initial outcomes from NRG Oncology RTOG 0539.

Adjuvant radiotherapy for atypical meningiomas.

Bagshaw HP, Burt LM, Jensen RL, Suneja G, Palmer CA, Couldwell WT, Shrieve DC
J Neurosurg 2017 Jun;126(6):1822-1828. Epub 2016 Sep 9 doi: 10.3171/2016.5.JNS152809. PMID: 27611201

See all (51)

Therapy

Sporadic and neurofibromatosis type 2-associated meningioma in children and adolescents.

Wagener K, Beckhaus J, Boekhoff S, Friedrich C, Müller HL
J Neurooncol 2023 Jul;163(3):555-563. Epub 2023 Jul 4 doi: 10.1007/s11060-023-04344-0. PMID: 37402092

Extent of resection and survival outcomes in World Health Organization grade II meningiomas.

Soni P, Davison MA, Shao J, Momin A, Lopez D, Angelov L, Barnett GH, Lee JH, Mohammadi AM, Kshettry VR, Recinos PF
J Neurooncol 2021 Jan;151(2):173-179. Epub 2020 Nov 17 doi: 10.1007/s11060-020-03632-3. PMID: 33205354

Intermediate-risk meningioma: initial outcomes from NRG Oncology RTOG 0539.

Review of controversies in management of non-benign meningioma.

Paldor I, Awad M, Sufaro YZ, Kaye AH, Shoshan Y
J Clin Neurosci 2016 Sep;31:37-46. Epub 2016 Jun 20 doi: 10.1016/j.jocn.2016.03.014. PMID: 27338209

World Health Organization grade II meningiomas.

Champeaux C, Dunn L
Acta Neurochir (Wien) 2016 May;158(5):921-9; discussion 929. Epub 2016 Mar 28 doi: 10.1007/s00701-016-2771-y. PMID: 27020441

See all (20)

Prognosis

Treatment and follow-up results of WHO grade II meningiomas.

Güdük M, Ekşi MŞ, Bozkurt B, Usseli Mİ, Erşen Danyeli A, Pamir MN
J Clin Neurosci 2021 Sep;91:354-364. Epub 2021 Jul 30 doi: 10.1016/j.jocn.2021.07.022. PMID: 34373052

Biomarkers for differentiating grade II meningiomas from grade I: a systematic review.

Sofela AA, McGavin L, Whitfield PC, Hanemann CO
Br J Neurosurg 2021 Dec;35(6):696-702. Epub 2021 Jun 21 doi: 10.1080/02688697.2021.1940853. PMID: 34148477

Intermediate-risk meningioma: initial outcomes from NRG Oncology RTOG 0539.

Adjuvant radiotherapy for atypical meningiomas.

Bagshaw HP, Burt LM, Jensen RL, Suneja G, Palmer CA, Couldwell WT, Shrieve DC
J Neurosurg 2017 Jun;126(6):1822-1828. Epub 2016 Sep 9 doi: 10.3171/2016.5.JNS152809. PMID: 27611201

Recent advances in the management of atypical meningiomas.

Messerer M, Richoz B, Cossu G, Dhermain F, Hottinger AF, Parker F, Levivier M, Daniel RT
Neurochirurgie 2016 Aug;62(4):213-22. Epub 2016 Jun 28 doi: 10.1016/j.neuchi.2016.02.003. PMID: 27370103

See all (56)

Clinical prediction guides

Imaging score for differentiation of meningioma grade.

Funari A, De la Garza Ramos R, Cezayirli P, Gelfand Y, Longo M, Ahmad S, Rahman S, Boyke AE, Levitt A, Hsu K, Agarwal V
Neuroradiology 2023 Mar;65(3):453-462. Epub 2022 Dec 12 doi: 10.1007/s00234-022-03101-w. PMID: 36504373

Biomarkers for differentiating grade II meningiomas from grade I: a systematic review.

Sofela AA, McGavin L, Whitfield PC, Hanemann CO
Br J Neurosurg 2021 Dec;35(6):696-702. Epub 2021 Jun 21 doi: 10.1080/02688697.2021.1940853. PMID: 34148477

Fibulin-2: A Novel Biomarker for Differentiating Grade II from Grade I Meningiomas.

Sofela AA, Hilton DA, Ammoun S, Baiz D, Adams CL, Ercolano E, Jenkinson MD, Kurian KM, Teo M, Whitfield PC, Sahm F, Hanemann CO
Int J Mol Sci 2021 Jan 8;22(2) doi: 10.3390/ijms22020560. PMID: 33429944 Free PMC Article

Extent of resection and survival outcomes in World Health Organization grade II meningiomas.

Relationship between tumor location, size, and WHO grade in meningioma.

Magill ST, Young JS, Chae R, Aghi MK, Theodosopoulos PV, McDermott MW
Neurosurg Focus 2018 Apr;44(4):E4. doi: 10.3171/2018.1.FOCUS17752. PMID: 29606048

See all (34)

Recent systematic reviews

Central nervous system clear cell meningioma: a systematic literature review.

Liang Q, Ge P, Liu Y, Zhu X, Lu S, Pan C, Ji Z, Wang Q, Wang Y
Neurosurg Rev 2024 Jan 6;47(1):35. doi: 10.1007/s10143-023-02251-6. PMID: 38183517

Biomarkers for differentiating grade II meningiomas from grade I: a systematic review.

Sofela AA, McGavin L, Whitfield PC, Hanemann CO
Br J Neurosurg 2021 Dec;35(6):696-702. Epub 2021 Jun 21 doi: 10.1080/02688697.2021.1940853. PMID: 34148477

Prognostic significance of brain invasion in meningiomas: systematic review and meta-analysis.

Nakasu S, Nakasu Y
Brain Tumor Pathol 2021 Apr;38(2):81-95. Epub 2021 Jan 6 doi: 10.1007/s10014-020-00390-y. PMID: 33403457

Radiotherapy as an adjuvant in the management of intracranial meningiomas: are we practising evidence-based medicine?

Marcus HJ, Price SJ, Wilby M, Santarius T, Kirollos RW
Br J Neurosurg 2008 Aug;22(4):520-8. doi: 10.1080/02688690802308687. PMID: 18803079

See all (4)

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Grade II meningioma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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