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Atypical Meningioma

MedGen UID:
96558
•Concept ID:
C0431122
•
Neoplastic Process
Synonym: Atypical meningioma
SNOMED CT: Atypical meningioma (128914005)

Definition

A WHO grade II meningioma characterized by the presence of brain invasion and an increased mitotic activity, or at least three of the following morphologic features: small cells, high cellularity, prominent nucleoli, lack of architectural pattern, and necrosis. [from NCI]

Professional guidelines

PubMed

Management of Atypical and Anaplastic Meningiomas.
Higgins D, Shah AH, Komotar RJ, Ivan ME
Neurosurg Clin N Am 2023 Jul;34(3):437-446. Epub 2023 Apr 18 doi: 10.1016/j.nec.2023.02.011. PMID: 37210132
The role of radiotherapy in the management of high-grade meningiomas.
Hwang KL, Hwang WL, Bussière MR, Shih HA
Chin Clin Oncol 2017 Jul;6(Suppl 1):S5. doi: 10.21037/cco.2017.06.09. PMID: 28758409
Management of Atypical and Anaplastic Meningiomas.
Buttrick S, Shah AH, Komotar RJ, Ivan ME
Neurosurg Clin N Am 2016 Apr;27(2):239-47. Epub 2016 Feb 20 doi: 10.1016/j.nec.2015.11.003. PMID: 27012388

Recent clinical studies

Etiology

Advances in the systemic therapy for recurrent meningiomas and the challenges ahead.
Li Y, Drappatz J
Expert Rev Neurother 2023 Jul-Dec;23(11):995-1004. Epub 2023 Sep 11 doi: 10.1080/14737175.2023.2254498. PMID: 37695700
Current experimental therapies for atypical and malignant meningiomas.
Corona AM, Di L, Shah AH, Crespo R, Eichberg DG, Lu VM, Luther EM, Komotar RJ, Ivan ME
J Neurooncol 2021 Jun;153(2):203-210. Epub 2021 May 5 doi: 10.1007/s11060-021-03759-x. PMID: 33950341
Prognostic factors for progression in atypical meningioma.
Shakir SI, Souhami L, Petrecca K, Mansure JJ, Singh K, Panet-Raymond V, Shenouda G, Al-Odaini AA, Abdulkarim B, Guiot MC
J Neurosurg 2018 Nov 1;129(5):1240-1248. Epub 2018 Jan 19 doi: 10.3171/2017.6.JNS17120. PMID: 29350599
Recent advances in the management of atypical meningiomas.
Messerer M, Richoz B, Cossu G, Dhermain F, Hottinger AF, Parker F, Levivier M, Daniel RT
Neurochirurgie 2016 Aug;62(4):213-22. Epub 2016 Jun 28 doi: 10.1016/j.neuchi.2016.02.003. PMID: 27370103
Atypical meningoma: current management dilemmas and prospective clinical trials.
Jenkinson MD, Weber DC, Haylock BJ, Mallucci CL, Zakaria R, Javadpour M
J Neurooncol 2015 Jan;121(1):1-7. Epub 2014 Sep 26 doi: 10.1007/s11060-014-1620-1. PMID: 25258253

Diagnosis

Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma.
Lan TL, Lin CF, Lee YY, Lin KH, Chang FC, Lin SC, Lee JC, Chou FI, Peir JJ, Liu HM, Mu PF, Chen YW
Int J Mol Sci 2023 Mar 4;24(5) doi: 10.3390/ijms24054978. PMID: 36902408Free PMC Article
Variations and natural history of primary intraparenchymal lesions associated with neurofibromatosis type 2.
Ishi Y, Harada T, Kameda H, Okada H, Yokota I, Okamoto M, Sawaya R, Motegi H, Yamaguchi S, Terasaka S, Kudo K, Fujimura M
Neuroradiology 2022 Feb;64(2):393-396. Epub 2021 Nov 23 doi: 10.1007/s00234-021-02809-5. PMID: 34812918
Recent advances in the management of atypical meningiomas.
Messerer M, Richoz B, Cossu G, Dhermain F, Hottinger AF, Parker F, Levivier M, Daniel RT
Neurochirurgie 2016 Aug;62(4):213-22. Epub 2016 Jun 28 doi: 10.1016/j.neuchi.2016.02.003. PMID: 27370103
The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.
Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW
Acta Neuropathol 2016 Jun;131(6):803-20. Epub 2016 May 9 doi: 10.1007/s00401-016-1545-1. PMID: 27157931
An atypical meningioma.
Lin W, Kevorkian CG
Am J Phys Med Rehabil 2008 Sep;87(9):693. doi: 10.1097/PHM.0b013e3181837cc7. PMID: 18716480

Therapy

Surgery alone versus surgery plus adjuvant radiotherapy for WHO grade 2 meningioma: meta-analysis of reconstructed time-to-event data.
Verly G, Bresciani L, Delfino T, Nascimento M, Magill ST, Galvão GDF
Neurosurg Rev 2024 Sep 28;47(1):702. doi: 10.1007/s10143-024-02946-4. PMID: 39333271
Salvage therapy outcomes for atypical meningioma.
Chen WC, Hara J, Magill ST, Wu A, Aghi MK, Theodosopoulos PV, Perry A, McDermott MW, Sneed PK, Raleigh DR, Braunstein SE
J Neurooncol 2018 Jun;138(2):425-433. Epub 2018 Feb 26 doi: 10.1007/s11060-018-2813-9. PMID: 29480505
Genomic diagnostics leading to the identification of a TFG-ROS1 fusion in a child with possible atypical meningioma.
Rossing M, Yde CW, Sehested A, Østrup O, Scheie D, Dangouloff-Ros V, Geoerger B, Vassal G, Nysom K
Cancer Genet 2017 Apr;212-213:32-37. Epub 2017 Mar 22 doi: 10.1016/j.cancergen.2017.03.005. PMID: 28449809
Atypical meningoma: current management dilemmas and prospective clinical trials.
Jenkinson MD, Weber DC, Haylock BJ, Mallucci CL, Zakaria R, Javadpour M
J Neurooncol 2015 Jan;121(1):1-7. Epub 2014 Sep 26 doi: 10.1007/s11060-014-1620-1. PMID: 25258253
Radiation induced meningioma with a short latent period following high dose cranial irradiation - case report and literature review.
Choudhary A, Pradhan S, Huda MF, Mohanty S, Kumar M
J Neurooncol 2006 Mar;77(1):73-7. Epub 2005 Nov 15 doi: 10.1007/s11060-005-9009-9. PMID: 16292489

Prognosis

Management of Atypical and Anaplastic Meningiomas.
Higgins D, Shah AH, Komotar RJ, Ivan ME
Neurosurg Clin N Am 2023 Jul;34(3):437-446. Epub 2023 Apr 18 doi: 10.1016/j.nec.2023.02.011. PMID: 37210132
Current experimental therapies for atypical and malignant meningiomas.
Corona AM, Di L, Shah AH, Crespo R, Eichberg DG, Lu VM, Luther EM, Komotar RJ, Ivan ME
J Neurooncol 2021 Jun;153(2):203-210. Epub 2021 May 5 doi: 10.1007/s11060-021-03759-x. PMID: 33950341
Prognostic factors for progression in atypical meningioma.
Shakir SI, Souhami L, Petrecca K, Mansure JJ, Singh K, Panet-Raymond V, Shenouda G, Al-Odaini AA, Abdulkarim B, Guiot MC
J Neurosurg 2018 Nov 1;129(5):1240-1248. Epub 2018 Jan 19 doi: 10.3171/2017.6.JNS17120. PMID: 29350599
Recent advances in the management of atypical meningiomas.
Messerer M, Richoz B, Cossu G, Dhermain F, Hottinger AF, Parker F, Levivier M, Daniel RT
Neurochirurgie 2016 Aug;62(4):213-22. Epub 2016 Jun 28 doi: 10.1016/j.neuchi.2016.02.003. PMID: 27370103
Management of Atypical and Anaplastic Meningiomas.
Buttrick S, Shah AH, Komotar RJ, Ivan ME
Neurosurg Clin N Am 2016 Apr;27(2):239-47. Epub 2016 Feb 20 doi: 10.1016/j.nec.2015.11.003. PMID: 27012388

Clinical prediction guides

Variations and natural history of primary intraparenchymal lesions associated with neurofibromatosis type 2.
Ishi Y, Harada T, Kameda H, Okada H, Yokota I, Okamoto M, Sawaya R, Motegi H, Yamaguchi S, Terasaka S, Kudo K, Fujimura M
Neuroradiology 2022 Feb;64(2):393-396. Epub 2021 Nov 23 doi: 10.1007/s00234-021-02809-5. PMID: 34812918
Long term follow up in 183 high grade meningioma: A single institutional experience.
Simonetti G, Silvani A, Tramacere I, Farinotti M, Legnani F, Pinzi V, Pollo B, Erbetta A, Gaviani P
Clin Neurol Neurosurg 2021 Aug;207:106808. Epub 2021 Jul 10 doi: 10.1016/j.clineuro.2021.106808. PMID: 34293659
Adjuvant Radiotherapy Versus Watchful Waiting for World Health Organization Grade II Atypical Meningioma: A Single-Institution Experience.
Bray DP, Quillin JW, Press RH, Yang Y, Chen Z, Eaton BR, Olson JJ
Neurosurgery 2021 Apr 15;88(5):E435-E442. doi: 10.1093/neuros/nyaa580. PMID: 33582821
A Risk Score Based on 5 Clinico-Pathological Variables Predicts Recurrence of Atypical Meningiomas.
Fioravanzo A, Caffo M, Di Bonaventura R, Gardiman MP, Ghimenton C, Ius T, Maffeis V, Martini M, Nicolato A, Pallini R, Pegolo E, Pinna G, Sala F, Skrap M, Volpin V, Barresi V
J Neuropathol Exp Neurol 2020 May 1;79(5):500-507. doi: 10.1093/jnen/nlaa018. PMID: 32232472
Atypical meningioma: a clinicopathological analysis.
Joseph E, Sandhyamani S, Rao MB, Nair S, Radhakrishnan VV
Neurol India 2000 Dec;48(4):338-42. PMID: 11146597

Recent systematic reviews

Should adjuvant radiotherapy be used in atypical meningioma (WHO grade 2) following gross total resection? A systematic review and Meta-analysis.
Wujanto C, Chan TY, Soon YY, Vellayappan B
Acta Oncol 2022 Sep;61(9):1075-1083. Epub 2022 Sep 2 doi: 10.1080/0284186X.2022.2116994. PMID: 36052871
Adjuvant radiotherapy versus observation following gross total resection for atypical meningioma: a systematic review and meta-analysis.
Chun SW, Kim KM, Kim MS, Kang H, Dho YS, Seo Y, Kim JW, Kim YH, Park CK
Radiat Oncol 2021 Feb 17;16(1):34. doi: 10.1186/s13014-021-01759-9. PMID: 33596974Free PMC Article
Association of Race with Survival in Intracranial World Health Organization Grade II and III Meningioma in the United States: Systematic Literature Review.
Elder T, Ejikeme T, Felton P, Raghavan A, Wright J, Wright CH, Zhou X, Duncan K, Sajatovic M, Hodges T
World Neurosurg 2020 Jun;138:e361-e369. Epub 2020 Mar 3 doi: 10.1016/j.wneu.2020.02.120. PMID: 32142947
A Systematic Review of Ion Radiotherapy in Maintaining Local Control Regarding Atypical and Anaplastic Meningiomas.
Coggins WS, Pham NK, Nguyen AV, Branch DW, Guillet JY, Korst G, Lall RR
World Neurosurg 2019 Dec;132:282-291. Epub 2019 Aug 30 doi: 10.1016/j.wneu.2019.08.149. PMID: 31476452
Adjuvant radiotherapy for atypical and malignant meningiomas: a systematic review.
Kaur G, Sayegh ET, Larson A, Bloch O, Madden M, Sun MZ, Barani IJ, James CD, Parsa AT
Neuro Oncol 2014 May;16(5):628-36. Epub 2014 Apr 2 doi: 10.1093/neuonc/nou025. PMID: 24696499Free PMC Article

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