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Breast adenomyoepithelioma

MedGen UID:
267278
•Concept ID:
C1510795
•
Neoplastic Process
Synonyms: Adenomyoepithelioma of the Breast; adenomyoepithelioma of the breast; BRAME; Breast Adenomyoepithelioma; breast adenomyoepithelioma; breast adenomyoepithelioma with malignant change; malignant adenomyoepithelioma of breast
 
Monarch Initiative: MONDO:0002066

Definition

A usually benign tumor arising from the breast. It is characterized by the proliferation of cells with myoepithelial differentiation around spaces which are lined by epithelial cells. Rarely, the epithelial and/or myoepithelial cells may undergo malignant transformation. Cases with malignant transformation may follow an aggressive clinical course, including recurrences and local and distant metastases. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast adenomyoepithelioma

Professional guidelines

PubMed

Update on selective special types of breast neoplasms: Focusing on controversies, differential diagnosis, and molecular genetic advances.
Wei S
Semin Diagn Pathol 2022 Sep;39(5):367-379. Epub 2022 Mar 18 doi: 10.1053/j.semdp.2022.03.001. PMID: 35331622
Triple-negative breast carcinomas of low malignant potential: review on diagnostic criteria and differential diagnoses.
Cima L, Kaya H, Marchiò C, Nishimura R, Wen HY, Fabbri VP, Foschini MP
Virchows Arch 2022 Jan;480(1):109-126. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03174-7. PMID: 34458945Free PMC Article
Genotype-phenotype associations in breast pathology: Achievements of the past quarter century.
Muller KE, Marotti JD
Breast J 2020 Jun;26(6):1123-1131. Epub 2020 May 4 doi: 10.1111/tbj.13861. PMID: 32367572

Recent clinical studies

Etiology

Diagnostic challenges of adenomyoepithelioma: A case report.
Pankratjevaite L, Lind K, Mele M, Lelkaitis G
Breast Dis 2022;41(1):325-330. doi: 10.3233/BD-210077. PMID: 35811510
Breast adenomyoepithelioma from a radiologic perspective.
Uchida M, Gatica C, Hasson D, Gallegos M, Pinochet MÁ
Radiologia (Engl Ed) 2022 Mar;64 Suppl 1:37-43. doi: 10.1016/j.rxeng.2021.06.004. PMID: 35428465
Adenomyoepithelioma of the breast: a proposal for classification.
Rakha E, Tan PH, Ellis I, Quinn C
Histopathology 2021 Oct;79(4):465-479. Epub 2021 Jun 13 doi: 10.1111/his.14380. PMID: 33829532
Clinical characteristics and outcomes of benign, atypical, and malignant breast adenomyoepithelioma: a single institution's experience.
Wiens N, Hoffman DI, Huang CY, Nayak A, Tchou J
Am J Surg 2020 Apr;219(4):651-654. Epub 2019 Apr 1 doi: 10.1016/j.amjsurg.2019.03.026. PMID: 30982573
Breast adenomyoepithelioma and adenomyoepithelioma with carcinoma (malignant adenomyoepithelioma) with associated breast malignancies: A case series emphasizing histologic, radiologic, and clinical correlation.
Moritz AW, Wiedenhoefer JF, Profit AP, Jagirdar J
Breast 2016 Oct;29:132-9. Epub 2016 Aug 3 doi: 10.1016/j.breast.2016.07.018. PMID: 27494340

Diagnosis

Adenomyoepithelioma of the Breast: A Report of 3 Cases.
AlQurashi M, Abdel Hadi M, Binammar AA, Al Muhanna A, Kussaibi H, Al Shammary E
Am J Case Rep 2022 Apr 11;23:e936070. doi: 10.12659/AJCR.936070. PMID: 35400730Free PMC Article
Adenomyoepithelioma of the breast: a proposal for classification.
Rakha E, Tan PH, Ellis I, Quinn C
Histopathology 2021 Oct;79(4):465-479. Epub 2021 Jun 13 doi: 10.1111/his.14380. PMID: 33829532
Clinical presentation, national practice patterns, and outcomes of breast adenomyoepithelioma.
Haque W, Verma V, Suzanne Klimberg V, Nangia J, Schwartz M, Brian Butler E, Teh BS
Breast J 2020 Apr;26(4):653-660. Epub 2019 Oct 2 doi: 10.1111/tbj.13638. PMID: 31578797
Clinical characteristics and outcomes of benign, atypical, and malignant breast adenomyoepithelioma: a single institution's experience.
Wiens N, Hoffman DI, Huang CY, Nayak A, Tchou J
Am J Surg 2020 Apr;219(4):651-654. Epub 2019 Apr 1 doi: 10.1016/j.amjsurg.2019.03.026. PMID: 30982573
Adenomyoepithelioma of the breast with late pulmonary metastases - case report and review of the literature.
Korolczuk A, Amarowicz M, Bąk K, Korobowicz E, Koncewicz T
J Cardiothorac Surg 2016 Aug 4;11(1):121. doi: 10.1186/s13019-016-0518-8. PMID: 27487934Free PMC Article

Prognosis

Adenomyoepithelioma of the breast with unusual confounding diagnostic feature: a case report.
Al Mulla L, Abdelhadi M, Al Muhanna A, Elsharkawy T, Al Nemer A
J Med Case Rep 2022 Aug 8;16(1):302. doi: 10.1186/s13256-022-03507-3. PMID: 35934703Free PMC Article
Adenomyoepithelioma of the Breast: A Report of 3 Cases.
AlQurashi M, Abdel Hadi M, Binammar AA, Al Muhanna A, Kussaibi H, Al Shammary E
Am J Case Rep 2022 Apr 11;23:e936070. doi: 10.12659/AJCR.936070. PMID: 35400730Free PMC Article
Clinical characteristics and outcomes of benign, atypical, and malignant breast adenomyoepithelioma: a single institution's experience.
Wiens N, Hoffman DI, Huang CY, Nayak A, Tchou J
Am J Surg 2020 Apr;219(4):651-654. Epub 2019 Apr 1 doi: 10.1016/j.amjsurg.2019.03.026. PMID: 30982573
A Case of Metastatic Malignant Breast Adenomyoepithelioma With a Codon-61 Mutation of HRAS.
Watanabe S, Otani T, Iwasa T, Takahama T, Takeda M, Sakai K, Nishio K, Ito A, Nakagawa K
Clin Breast Cancer 2019 Oct;19(5):e589-e592. Epub 2019 Jun 20 doi: 10.1016/j.clbc.2019.05.001. PMID: 31301988
Breast adenomyoepithelioma: a case report with malignant proliferation of epithelial and myoepithelial elements.
Petrozza V, Pasciuti G, Pacchiarotti A, Tomao F, Zoratto F, Rossi L, Fontana A, Censi F, Sardella B, Di Cristofano C, Porta N, Della Rocca C
World J Surg Oncol 2013 Oct 30;11:285. doi: 10.1186/1477-7819-11-285. PMID: 24171817Free PMC Article

Clinical prediction guides

Adenomyoepithelioma of the Breast: A Report of 3 Cases.
AlQurashi M, Abdel Hadi M, Binammar AA, Al Muhanna A, Kussaibi H, Al Shammary E
Am J Case Rep 2022 Apr 11;23:e936070. doi: 10.12659/AJCR.936070. PMID: 35400730Free PMC Article
Clinical characteristics and outcomes of benign, atypical, and malignant breast adenomyoepithelioma: a single institution's experience.
Wiens N, Hoffman DI, Huang CY, Nayak A, Tchou J
Am J Surg 2020 Apr;219(4):651-654. Epub 2019 Apr 1 doi: 10.1016/j.amjsurg.2019.03.026. PMID: 30982573
Breast adenomyoepithelioma: a case report with malignant proliferation of epithelial and myoepithelial elements.
Petrozza V, Pasciuti G, Pacchiarotti A, Tomao F, Zoratto F, Rossi L, Fontana A, Censi F, Sardella B, Di Cristofano C, Porta N, Della Rocca C
World J Surg Oncol 2013 Oct 30;11:285. doi: 10.1186/1477-7819-11-285. PMID: 24171817Free PMC Article

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