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Breast myoepithelial tumor

MedGen UID:: 267411
•Concept ID:: C1511319
•: Neoplastic Process

Synonyms:	Breast Myoepithelial Neoplasm; breast myoepithelial neoplasm; Breast Myoepithelial Tumor; breast myoepithelial tumor

Monarch Initiative:	MONDO:0002483

Definition

A benign or malignant tumor that arises from the breast and originates from or is composed of myoepithelial cells. Representative examples include adenomyoepithelioma, myoepitheliosis, and malignant myoepithelioma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBreast myoepithelial tumor

Phenotypic abnormality
- Abnormality of the breast
  - Abnormal breast morphology
    - Breast neoplasm
      - Breast Soft Tissue Neoplasm
        Breast myoepithelial tumor
        Breast adenomyoepithelioma
        Benign breast adenomyoepithelioma
        Malignant Breast Adenomyoepithelioma
        Breast myoepitheliosis
        Breast Atypical Myoepitheliosis
        Intraductal breast myoepitheliosis
        Periductal breast myoepitheliosis
        Malignant breast myoepithelioma

Professional guidelines

PubMed

Oncocytoid Salivary Tumors: Differential Diagnosis and Utility of Newly Described Immunohistochemistry.

Katabi N
Head Neck Pathol 2024 Mar 19;18(1):20. doi: 10.1007/s12105-024-01622-9. PMID: 38502259 Free PMC Article

Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.

Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592

Basal phenotype breast cancer: implications for treatment and prognosis.

Pazaiti A, Fentiman IS
Womens Health (Lond) 2011 Mar;7(2):181-202. doi: 10.2217/whe.11.5. PMID: 21410345

See all (21)

Recent clinical studies

Etiology

Breast adenomyoepithelioma from a radiologic perspective.

Uchida M, Gatica C, Hasson D, Gallegos M, Pinochet MÁ
Radiologia (Engl Ed) 2022 Mar;64 Suppl 1:37-43. doi: 10.1016/j.rxeng.2021.06.004. PMID: 35428465

Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma.

Risom T, Glass DR, Averbukh I, Liu CC, Baranski A, Kagel A, McCaffrey EF, Greenwald NF, Rivero-Gutiérrez B, Strand SH, Varma S, Kong A, Keren L, Srivastava S, Zhu C, Khair Z, Veis DJ, Deschryver K, Vennam S, Maley C, Hwang ES, Marks JR, Bendall SC, Colditz GA, West RB, Angelo M
Cell 2022 Jan 20;185(2):299-310.e18. doi: 10.1016/j.cell.2021.12.023. PMID: 35063072 Free PMC Article

Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.

Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592

CDKN2A loss and PIK3CA mutation in myoepithelial-like metaplastic breast cancer.

Bartels S, van Luttikhuizen JL, Christgen M, Mägel L, Luft A, Hänzelmann S, Lehmann U, Schlegelberger B, Leo F, Steinemann D, Kreipe H
J Pathol 2018 Jul;245(3):373-383. Epub 2018 May 28 doi: 10.1002/path.5091. PMID: 29708279

Mammary epithelial stem cells.

Smith GH, Chepko G
Microsc Res Tech 2001 Jan 15;52(2):190-203. doi: 10.1002/1097-0029(20010115)52:2<190::AID-JEMT1005>3.0.CO;2-O. PMID: 11169867

See all (192)

Diagnosis

Malignant breast myoepithelioma: A systematic review.

Huin M, Body G, Arbion F, Ouldamer L
J Gynecol Obstet Hum Reprod 2022 Dec;51(10):102481. Epub 2022 Oct 5 doi: 10.1016/j.jogoh.2022.102481. PMID: 36208828

Intraductal Carcinomas of the Salivary Gland.

Todorovic E, Weinreb I
Surg Pathol Clin 2021 Mar;14(1):1-15. Epub 2021 Jan 6 doi: 10.1016/j.path.2020.09.003. PMID: 33526215

Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.

Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592

Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.

Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889

Preinvasive breast cancer.

Sgroi DC
Annu Rev Pathol 2010;5:193-221. doi: 10.1146/annurev.pathol.4.110807.092306. PMID: 19824828 Free PMC Article

See all (430)

Therapy

Oncoprotein GT198 vaccination delays tumor growth in MMTV-PyMT mice.

Achyut BR, Zhang H, Angara K, Mivechi NF, Arbab AS, Ko L
Cancer Lett 2020 Apr 28;476:57-66. Epub 2020 Feb 12 doi: 10.1016/j.canlet.2020.02.005. PMID: 32061755 Free PMC Article

Developmental signaling pathways regulating mammary stem cells and contributing to the etiology of triple-negative breast cancer.

Rangel MC, Bertolette D, Castro NP, Klauzinska M, Cuttitta F, Salomon DS
Breast Cancer Res Treat 2016 Apr;156(2):211-26. Epub 2016 Mar 11 doi: 10.1007/s10549-016-3746-7. PMID: 26968398 Free PMC Article

Basal breast cancer: a complex and deadly molecular subtype.

Bertucci F, Finetti P, Birnbaum D
Curr Mol Med 2012 Jan;12(1):96-110. doi: 10.2174/156652412798376134. PMID: 22082486 Free PMC Article

Triple negative breast carcinomas: similarities and differences with basal like carcinomas.

Lerma E, Barnadas A, Prat J
Appl Immunohistochem Mol Morphol 2009 Dec;17(6):483-94. doi: 10.1097/PAI.0b013e3181a725eb. PMID: 19620842

Timing of dietary estrogenic exposures and breast cancer risk.

De Assis S, Hilakivi-Clarke L
Ann N Y Acad Sci 2006 Nov;1089:14-35. doi: 10.1196/annals.1386.039. PMID: 17261753

See all (33)

Prognosis

Avoiding "False Positive" and "False Negative" Immunohistochemical Results in Breast Pathology.

Li Z, Dabbs DJ
Pathobiology 2022;89(5):309-323. Epub 2022 Mar 4 doi: 10.1159/000521682. PMID: 35249034

Intraductal Carcinomas of the Salivary Gland.

Todorovic E, Weinreb I
Surg Pathol Clin 2021 Mar;14(1):1-15. Epub 2021 Jan 6 doi: 10.1016/j.path.2020.09.003. PMID: 33526215

Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.

Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889

Identifying progression predictors of breast ductal carcinoma in situ.

Yeong J, Thike AA, Tan PH, Iqbal J
J Clin Pathol 2017 Feb;70(2):102-108. Epub 2016 Nov 18 doi: 10.1136/jclinpath-2016-204154. PMID: 27864452

Basal phenotype breast cancer: implications for treatment and prognosis.

Pazaiti A, Fentiman IS
Womens Health (Lond) 2011 Mar;7(2):181-202. doi: 10.2217/whe.11.5. PMID: 21410345

See all (263)

Clinical prediction guides

Pan-cancer spatially resolved single-cell analysis reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment.

Ma C, Yang C, Peng A, Sun T, Ji X, Mi J, Wei L, Shen S, Feng Q
Mol Cancer 2023 Oct 13;22(1):170. doi: 10.1186/s12943-023-01876-x. PMID: 37833788 Free PMC Article

Avoiding "False Positive" and "False Negative" Immunohistochemical Results in Breast Pathology.

Li Z, Dabbs DJ
Pathobiology 2022;89(5):309-323. Epub 2022 Mar 4 doi: 10.1159/000521682. PMID: 35249034

Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.

Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889

Implications of nestin in breast cancer pathogenesis (Review).

Nowak A, Dziegiel P
Int J Oncol 2018 Aug;53(2):477-487. Epub 2018 Jun 14 doi: 10.3892/ijo.2018.4441. PMID: 29901100

Preinvasive breast cancer.

Sgroi DC
Annu Rev Pathol 2010;5:193-221. doi: 10.1146/annurev.pathol.4.110807.092306. PMID: 19824828 Free PMC Article

See all (280)

Recent systematic reviews

Malignant breast myoepithelioma: A systematic review.

Huin M, Body G, Arbion F, Ouldamer L
J Gynecol Obstet Hum Reprod 2022 Dec;51(10):102481. Epub 2022 Oct 5 doi: 10.1016/j.jogoh.2022.102481. PMID: 36208828

Impact of adjuvant therapy on survival in patients with myoepithelial carcinoma: A systematic review and individual patient data analysis of 691 patients.

Giridhar P, Gupta P, Mallick S, Upadhyay AD, Rath GK
Radiother Oncol 2019 Nov;140:125-130. Epub 2019 Jul 2 doi: 10.1016/j.radonc.2019.06.017. PMID: 31276988

See all (2)

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Breast myoepithelial tumor

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

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Practice guidelines

Consumer resources

Reviews

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