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Inflammatory liposarcoma

MedGen UID:
234588
•Concept ID:
C1370890
•
Neoplastic Process
Synonyms: Inflammatory ALT/WDLPS; Inflammatory Atypical Lipomatous Tumor/Well Differentiated Liposarcoma; Inflammatory Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma; Inflammatory Liposarcoma; inflammatory liposarcoma
SNOMED CT: Inflammatory liposarcoma (1290641001); Inflammatory liposarcoma (1290901007)
 
Monarch Initiative: MONDO:0004510

Definition

A rare morphologic variant of atypical lipomatous tumor/well differentiated liposarcoma occurring most often in the retroperitoneum. It is characterized by the presence of a predominant chronic inflammatory infiltrate. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInflammatory liposarcoma

Professional guidelines

PubMed

Trabectedin for the treatment of soft tissue sarcomas.
De Sanctis R, Marrari A, Santoro A
Expert Opin Pharmacother 2016 Aug;17(11):1569-77. Epub 2016 Jul 4 doi: 10.1080/14656566.2016.1204295. PMID: 27328277
Histology- and non-histology-driven therapy for treatment of soft tissue sarcomas.
Casali PG
Ann Oncol 2012 Sep;23 Suppl 10:x167-9. doi: 10.1093/annonc/mds349. PMID: 22987955
Gastrointestinal stromal tumors--definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis.
Miettinen M, Lasota J
Virchows Arch 2001 Jan;438(1):1-12. doi: 10.1007/s004280000338. PMID: 11213830

Recent clinical studies

Etiology

Fine-needle aspiration cytology of well-differentiated inflammatory liposarcoma: a case report with histologic follow-up.
Wu HH, Harshbarger KE, McCandless DG
Diagn Cytopathol 1999 Apr;20(4):229-32. doi: 10.1002/(sici)1097-0339(199904)20:4<229::aid-dc9>3.0.co;2-4. PMID: 10204107
Lymphocyte-rich well-differentiated liposarcoma: report of nine cases.
Argani P, Facchetti F, Inghirami G, Rosai J
Am J Surg Pathol 1997 Aug;21(8):884-95. doi: 10.1097/00000478-199708000-00002. PMID: 9255251
Well-differentiated inflammatory liposarcoma: an uncommon and easily overlooked variant of a common sarcoma.
Kraus MD, Guillou L, Fletcher CD
Am J Surg Pathol 1997 May;21(5):518-27. doi: 10.1097/00000478-199705000-00003. PMID: 9158675

Diagnosis

Castleman Disease with MDM2/CDK4 Protein Expression: a Potential Mimic of Inflammatory Variant of Liposarcoma with Significant Consequences.
Georgantzoglou N, Baker M, Liu X, Kerr DA, Linos K
Int J Surg Pathol 2022 Oct;30(7):753-759. Epub 2022 Feb 11 doi: 10.1177/10668969221080083. PMID: 35147042
Detection of MDM2 gene amplification or protein expression distinguishes sclerosing mesenteritis and retroperitoneal fibrosis from inflammatory well-differentiated liposarcoma.
Weaver J, Goldblum JR, Turner S, Tubbs RR, Wang WL, Lazar AJ, Rubin BP
Mod Pathol 2009 Jan;22(1):66-70. Epub 2008 Oct 3 doi: 10.1038/modpathol.2008.153. PMID: 18836421
Well-differentiated liposarcoma (atypical lipomatous tumors).
Laurino L, Furlanetto A, Orvieto E, Dei Tos AP
Semin Diagn Pathol 2001 Nov;18(4):258-62. PMID: 11757865
Lymphocyte-rich well-differentiated liposarcoma: report of nine cases.
Argani P, Facchetti F, Inghirami G, Rosai J
Am J Surg Pathol 1997 Aug;21(8):884-95. doi: 10.1097/00000478-199708000-00002. PMID: 9255251
Well-differentiated inflammatory liposarcoma: an uncommon and easily overlooked variant of a common sarcoma.
Kraus MD, Guillou L, Fletcher CD
Am J Surg Pathol 1997 May;21(5):518-27. doi: 10.1097/00000478-199705000-00003. PMID: 9158675

Prognosis

Fine-needle aspiration cytology of well-differentiated inflammatory liposarcoma: a case report with histologic follow-up.
Wu HH, Harshbarger KE, McCandless DG
Diagn Cytopathol 1999 Apr;20(4):229-32. doi: 10.1002/(sici)1097-0339(199904)20:4<229::aid-dc9>3.0.co;2-4. PMID: 10204107
Lymphocyte-rich well-differentiated liposarcoma: report of nine cases.
Argani P, Facchetti F, Inghirami G, Rosai J
Am J Surg Pathol 1997 Aug;21(8):884-95. doi: 10.1097/00000478-199708000-00002. PMID: 9255251

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