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Stromal sarcoma

MedGen UID:
235091
•Concept ID:
C1370723
•
Neoplastic Process
Synonyms: Malignant stromal tumor; Stromal Sarcoma; stromal sarcoma; stromal sarcoma, malignant; stromal tumor, malignant
SNOMED CT: Stromal sarcoma (128753005); Malignant stromal tumor (253048008)
 
Monarch Initiative: MONDO:0044337

Definition

A malignant neoplasm characterized by the presence of atypical mesenchymal-stromal cells. Representative examples include endometrial stromal sarcoma and prostate stromal sarcoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStromal sarcoma

Professional guidelines

PubMed

Current Treatment Options: Uterine Sarcoma.
Lewis D, Liang A, Mason T, Ferriss JS
Curr Treat Options Oncol 2024 Jul;25(7):829-853. Epub 2024 May 31 doi: 10.1007/s11864-024-01214-3. PMID: 38819624
Endometrial stromal tumors of the uterus: Epidemiology, pathological and biological features, treatment options and clinical outcomes.
Gadducci A, Multinu F, De Vitis LA, Cosio S, Carinelli S, Aletti GD
Gynecol Oncol 2023 Apr;171:95-105. Epub 2023 Feb 24 doi: 10.1016/j.ygyno.2023.02.009. PMID: 36842409
Systemic treatment in adult uterine sarcomas.
Desar IME, Ottevanger PB, Benson C, van der Graaf WTA
Crit Rev Oncol Hematol 2018 Feb;122:10-20. Epub 2017 Dec 14 doi: 10.1016/j.critrevonc.2017.12.009. PMID: 29458779

Recent clinical studies

Etiology

Current Concepts in the Imaging of Uterine Sarcomas.
Petrocelli R, Hindman N, Reinhold C
Radiol Clin North Am 2023 Jul;61(4):627-638. Epub 2023 Apr 3 doi: 10.1016/j.rcl.2023.02.008. PMID: 37169428
A nomogram for predicting overall survival in patients with low-grade endometrial stromal sarcoma: A population-based analysis.
Wu J, Zhang H, Li L, Hu M, Chen L, Xu B, Song Q
Cancer Commun (Lond) 2020 Jul;40(7):301-312. Epub 2020 Jun 18 doi: 10.1002/cac2.12067. PMID: 32558385Free PMC Article
Beyond Smooth Muscle-Other Mesenchymal Neoplasms of the Uterus.
Dickson BC
Surg Pathol Clin 2019 Mar;12(1):107-137. Epub 2018 Dec 24 doi: 10.1016/j.path.2018.10.005. PMID: 30709439
Current management of uterine sarcomas.
García-Martínez E, Egea Prefasi L, García-Donas J, Escolar-Pérez PP, Pastor F, González-Martín A
Clin Transl Oncol 2011 May;13(5):307-14. doi: 10.1007/s12094-011-0659-0. PMID: 21596658
Uterine sarcomas: a review.
D'Angelo E, Prat J
Gynecol Oncol 2010 Jan;116(1):131-9. Epub 2009 Oct 23 doi: 10.1016/j.ygyno.2009.09.023. PMID: 19853898

Diagnosis

Endometrial stromal tumors of the uterus: Epidemiology, pathological and biological features, treatment options and clinical outcomes.
Gadducci A, Multinu F, De Vitis LA, Cosio S, Carinelli S, Aletti GD
Gynecol Oncol 2023 Apr;171:95-105. Epub 2023 Feb 24 doi: 10.1016/j.ygyno.2023.02.009. PMID: 36842409
Update on Uterine Mesenchymal Neoplasms.
Kertowidjojo EC, Bennett JA
Surg Pathol Clin 2022 Jun;15(2):315-340. Epub 2022 May 20 doi: 10.1016/j.path.2022.02.008. PMID: 35715164
State of the science: Uterine sarcomas: From pathology to practice.
Shushkevich A, Thaker PH, Littell RD, Shah NA, Chiang S, Thornton K, Hensley ML, Slomovitz BM, Holcomb KM, Leitao MM, Toboni MD, Powell MA, Levine DA, Dowdy SC, Klopp A, Brown J
Gynecol Oncol 2020 Oct;159(1):3-7. Epub 2020 Aug 21 doi: 10.1016/j.ygyno.2020.08.008. PMID: 32839026
A nomogram for predicting overall survival in patients with low-grade endometrial stromal sarcoma: A population-based analysis.
Wu J, Zhang H, Li L, Hu M, Chen L, Xu B, Song Q
Cancer Commun (Lond) 2020 Jul;40(7):301-312. Epub 2020 Jun 18 doi: 10.1002/cac2.12067. PMID: 32558385Free PMC Article
Endometrial stromal sarcoma--the new genetic paradigm.
Lee CH, Nucci MR
Histopathology 2015 Jul;67(1):1-19. Epub 2015 Jan 22 doi: 10.1111/his.12594. PMID: 25355621

Therapy

State of the science: Uterine sarcomas: From pathology to practice.
Shushkevich A, Thaker PH, Littell RD, Shah NA, Chiang S, Thornton K, Hensley ML, Slomovitz BM, Holcomb KM, Leitao MM, Toboni MD, Powell MA, Levine DA, Dowdy SC, Klopp A, Brown J
Gynecol Oncol 2020 Oct;159(1):3-7. Epub 2020 Aug 21 doi: 10.1016/j.ygyno.2020.08.008. PMID: 32839026
Current Status of Magnetic Resonance Imaging in Patients with Malignant Uterine Neoplasms: A Review.
Huang YT, Huang YL, Ng KK, Lin G
Korean J Radiol 2019 Jan;20(1):18-33. Epub 2018 Dec 27 doi: 10.3348/kjr.2018.0090. PMID: 30627019Free PMC Article
Gynecological sarcomas: what's new in 2018, a brief review of published literature.
Gantzer J, Ray-Coquard I
Curr Opin Oncol 2018 Jul;30(4):246-251. doi: 10.1097/CCO.0000000000000462. PMID: 29846243
Current management of uterine sarcomas.
García-Martínez E, Egea Prefasi L, García-Donas J, Escolar-Pérez PP, Pastor F, González-Martín A
Clin Transl Oncol 2011 May;13(5):307-14. doi: 10.1007/s12094-011-0659-0. PMID: 21596658
Uterine sarcomas: a review.
D'Angelo E, Prat J
Gynecol Oncol 2010 Jan;116(1):131-9. Epub 2009 Oct 23 doi: 10.1016/j.ygyno.2009.09.023. PMID: 19853898

Prognosis

Current Concepts in the Imaging of Uterine Sarcomas.
Petrocelli R, Hindman N, Reinhold C
Radiol Clin North Am 2023 Jul;61(4):627-638. Epub 2023 Apr 3 doi: 10.1016/j.rcl.2023.02.008. PMID: 37169428
A nomogram for predicting overall survival in patients with low-grade endometrial stromal sarcoma: A population-based analysis.
Wu J, Zhang H, Li L, Hu M, Chen L, Xu B, Song Q
Cancer Commun (Lond) 2020 Jul;40(7):301-312. Epub 2020 Jun 18 doi: 10.1002/cac2.12067. PMID: 32558385Free PMC Article
Beyond Smooth Muscle-Other Mesenchymal Neoplasms of the Uterus.
Dickson BC
Surg Pathol Clin 2019 Mar;12(1):107-137. Epub 2018 Dec 24 doi: 10.1016/j.path.2018.10.005. PMID: 30709439
Uterine sarcomas.
Mbatani N, Olawaiye AB, Prat J
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:51-58. doi: 10.1002/ijgo.12613. PMID: 30306577
Atypical prostatic stromal lesions.
Cohen MB
Adv Anat Pathol 1998 Nov;5(6):359-66. doi: 10.1097/00125480-199811000-00002. PMID: 10095877

Clinical prediction guides

A nomogram for predicting overall survival in patients with low-grade endometrial stromal sarcoma: A population-based analysis.
Wu J, Zhang H, Li L, Hu M, Chen L, Xu B, Song Q
Cancer Commun (Lond) 2020 Jul;40(7):301-312. Epub 2020 Jun 18 doi: 10.1002/cac2.12067. PMID: 32558385Free PMC Article
Aromatase inhibitor therapy for endometrial stromal sarcoma - two-centre experience.
Serkies K, Abacjew-Chmyłko A, Wieczorek-Rutkowska M, Pęksa R
Ginekol Pol 2018;89(11):607-610. doi: 10.5603/GP.a2018.0104. PMID: 30508212
Fertility-sparing surgery for patients with low-grade endometrial stromal sarcoma.
Xie W, Cao D, Yang J, Jiang X, Shen K, Pan L, Huang H, Lang J, You Y, Chen J
Oncotarget 2017 Feb 7;8(6):10602-10608. doi: 10.18632/oncotarget.12491. PMID: 27736798Free PMC Article
Malignant Transformation of Vaginal Endometriosis - A Review of Literature.
Cozzolino M, Nasioudis D, Sisti G, Coccia ME
Gynecol Obstet Invest 2017;82(2):105-112. Epub 2016 Sep 13 doi: 10.1159/000449198. PMID: 27618565
Aromatase inhibitors in gynecologic cancers.
Krasner C
J Steroid Biochem Mol Biol 2007 Aug-Sep;106(1-5):76-80. Epub 2007 May 24 doi: 10.1016/j.jsbmb.2007.05.026. PMID: 17826626

Recent systematic reviews

Extrauterine endometrial stromal sarcoma: A systematic review and outcome analysis.
Deb PQ, Heller DS
Ann Diagn Pathol 2022 Aug;59:151966. Epub 2022 May 10 doi: 10.1016/j.anndiagpath.2022.151966. PMID: 35569210
Endometrial stromal sarcoma: A review of rare mesenchymal uterine neoplasm.
Capozzi VA, Monfardini L, Ceni V, Cianciolo A, Butera D, Gaiano M, Berretta R
J Obstet Gynaecol Res 2020 Nov;46(11):2221-2236. Epub 2020 Aug 23 doi: 10.1111/jog.14436. PMID: 32830415
Uterine sarcoma part III-Targeted therapy: The Taiwan Association of Gynecology (TAG) systematic review.
Yen MS, Chen JR, Wang PH, Wen KC, Chen YJ, Ng HT; Taiwan Association of Gynecology Systematic Review Group
Taiwan J Obstet Gynecol 2016 Oct;55(5):625-634. doi: 10.1016/j.tjog.2016.07.001. PMID: 27751406
Uterine sarcoma Part II-Uterine endometrial stromal sarcoma: The TAG systematic review.
Horng HC, Wen KC, Wang PH, Chen YJ, Yen MS, Ng HT; Taiwan Association of Gynecology Systematic Review Group
Taiwan J Obstet Gynecol 2016 Aug;55(4):472-9. doi: 10.1016/j.tjog.2016.04.034. PMID: 27590366
Endometrial stromal sarcoma: a systematic review.
Rauh-Hain JA, del Carmen MG
Obstet Gynecol 2013 Sep;122(3):676-83. doi: 10.1097/AOG.0b013e3182a189ac. PMID: 23921879

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