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Testicular Mixed Germ Cell-Sex Cord-Stromal Tumor, Unclassified

MedGen UID:
237004
•Concept ID:
C1336719
•
Neoplastic Process
Synonyms: Testicular Mixed Germ Cell-Sex Cord Neoplasm; Testicular Mixed Germ Cell-Sex Cord Tumor; Testicular Mixed Germ Cell-Sex Cord-Stromal Neoplasm; Testicular Mixed Germ Cell-Sex Cord-Stromal Tumor

Definition

A tumor that arises from the testis and is characterized by the presence of a neoplastic germ cell component and a neoplastic sex cord-stromal component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular Mixed Germ Cell-Sex Cord-Stromal Tumor, Unclassified

Recent clinical studies

Etiology

Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems.
Young RH
Mod Pathol 2005 Feb;18 Suppl 2:S81-98. doi: 10.1038/modpathol.3800311. PMID: 15502809

Diagnosis

Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems.
Young RH
Mod Pathol 2005 Feb;18 Suppl 2:S81-98. doi: 10.1038/modpathol.3800311. PMID: 15502809
OCT4 staining in testicular tumors: a sensitive and specific marker for seminoma and embryonal carcinoma.
Jones TD, Ulbright TM, Eble JN, Baldridge LA, Cheng L
Am J Surg Pathol 2004 Jul;28(7):935-40. doi: 10.1097/00000478-200407000-00014. PMID: 15223965
Neoplastic potential of germ cells in relation to disturbances of gonadal organogenesis and changes in karyotype.
Słowikowska-Hilczer J, Romer TE, Kula K
J Androl 2003 Mar-Apr;24(2):270-8. doi: 10.1002/j.1939-4640.2003.tb02672.x. PMID: 12634315
Inhibin-alpha CD99, HEA125, PLAP, and chromogranin immunoreactivity in testicular neoplasms and the androgen insensitivity syndrome.
Kommoss F, Oliva E, Bittinger F, Kirkpatrick CJ, Amin MB, Bhan AK, Young RH, Scully RE
Hum Pathol 2000 Sep;31(9):1055-61. doi: 10.1053/hupa.2000.16237. PMID: 11014571
Sex cord-stromal tumors of the testis with entrapped germ cells: a lesion mimicking unclassified mixed germ cell sex cord-stromal tumors.
Ulbright TM, Srigley JR, Reuter VE, Wojno K, Roth LM, Young RH
Am J Surg Pathol 2000 Apr;24(4):535-42. doi: 10.1097/00000478-200004000-00007. PMID: 10757400

Prognosis

Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems.
Young RH
Mod Pathol 2005 Feb;18 Suppl 2:S81-98. doi: 10.1038/modpathol.3800311. PMID: 15502809
Neoplastic potential of germ cells in relation to disturbances of gonadal organogenesis and changes in karyotype.
Słowikowska-Hilczer J, Romer TE, Kula K
J Androl 2003 Mar-Apr;24(2):270-8. doi: 10.1002/j.1939-4640.2003.tb02672.x. PMID: 12634315

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