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Mediastinal teratoma

MedGen UID:
233175
•Concept ID:
C1334682
•
Neoplastic Process
Synonyms: Mediastinal Teratoma; mediastinum teratoma; Teratoma of Mediastinum; teratoma of mediastinum; Teratoma of the Mediastinum; Teratoma of the mediastinum; Thymic Teratoma
 
HPO: HP:0030741
Monarch Initiative: MONDO:0003518

Definition

A teratoma located within the mediastinum (the cavity between the pleural sacs that contains the heart and all of the thoracic viscera except the lungs). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMediastinal teratoma

Professional guidelines

PubMed

Surgical management of thoracic malignancies invading the heart or great vessels.
Park BJ, Bacchetta M, Bains MS, Downey RJ, Flores R, Rusch VW, Girardi LN
Ann Thorac Surg 2004 Sep;78(3):1024-30. doi: 10.1016/j.athoracsur.2004.02.043. PMID: 15337042
Effective treatment for malignant mediastinal teratoma.
Parker D, Holford CP, Begent RH, Newlands ES, Rustin GJ, Makey AR, Bagshawe KD
Thorax 1983 Dec;38(12):897-902. doi: 10.1136/thx.38.12.897. PMID: 6198739Free PMC Article

Recent clinical studies

Etiology

Retrosternal goiter in thoracic surgical practice.
Anikin V, Welman K, Asadi N, Dalal P, Reshetov I, Beddow E
Khirurgiia (Mosk) 2021;(12):20-26. doi: 10.17116/hirurgia202112120. PMID: 34941205
Surgical treatment of benign mediastinal teratoma: summary of experience of 108 cases.
Tian Z, Liu H, Li S, Chen Y, Ma D, Han Z, Huang C
J Cardiothorac Surg 2020 Feb 17;15(1):36. doi: 10.1186/s13019-020-1075-8. PMID: 32066478Free PMC Article
Analysis of chromosome 12p over-representation and clinicopathological features in mediastinal teratomas.
Lee T, Seo Y, Han J, Kwon GY
Pathology 2019 Jan;51(1):62-66. Epub 2018 Nov 20 doi: 10.1016/j.pathol.2018.10.002. PMID: 30470411
Robotically enhanced mediastinal teratoma resection: a case report and review of the literature.
Willems E, Martens S, Beelen R
Acta Chir Belg 2016 Oct;116(5):309-312. Epub 2016 May 26 doi: 10.1080/00015458.2016.1147264. PMID: 27426655
Mediastinal teratoma and trichoptysis.
Guibert N, Attias D, Pontier S, Berjaud J, Lavialle-Guillautreau V, Didier A
Ann Thorac Surg 2011 Jul;92(1):351-3. doi: 10.1016/j.athoracsur.2011.01.036. PMID: 21718876

Diagnosis

Prenatal ultrasonic features of a mediastinal teratoma: A case report and literature review.
Xu L, Ma Q, Tian X, Huang W, Zhong W, Shang N
J Clin Ultrasound 2022 Sep;50(7):1004-1012. Epub 2022 Apr 8 doi: 10.1002/jcu.23203. PMID: 35394661
Retrosternal goiter in thoracic surgical practice.
Anikin V, Welman K, Asadi N, Dalal P, Reshetov I, Beddow E
Khirurgiia (Mosk) 2021;(12):20-26. doi: 10.17116/hirurgia202112120. PMID: 34941205
A giant mediastinal teratoma: From diagnosis to complete resection and <em>restitutio ad integrum</em>.
Cocchia R, Guggino G, Romano L, Annunziata R, Raucci A, Sorice M, Ranieri B, Russo G, Mauro C, Bossone E
Monaldi Arch Chest Dis 2021 Sep 28;92(1) doi: 10.4081/monaldi.2021.1935. PMID: 34585559
Mediastinal teratoma and trichoptysis.
Guibert N, Attias D, Pontier S, Berjaud J, Lavialle-Guillautreau V, Didier A
Ann Thorac Surg 2011 Jul;92(1):351-3. doi: 10.1016/j.athoracsur.2011.01.036. PMID: 21718876
Management of fetal lung lesions.
Adzick NS
Clin Perinatol 2009 Jun;36(2):363-76, x. doi: 10.1016/j.clp.2009.03.001. PMID: 19559325

Therapy

Surgical treatment of benign mediastinal teratoma: summary of experience of 108 cases.
Tian Z, Liu H, Li S, Chen Y, Ma D, Han Z, Huang C
J Cardiothorac Surg 2020 Feb 17;15(1):36. doi: 10.1186/s13019-020-1075-8. PMID: 32066478Free PMC Article
Mediastinal Germ Cell Tumors in Pediatric Patients: A Report From the Italian Association of Pediatric Hematology and Oncology.
De Pasquale MD, Crocoli A, Conte M, Indolfi P, D'Angelo P, Boldrini R, Terenziani M, Inserra A
Pediatr Blood Cancer 2016 May;63(5):808-12. Epub 2016 Jan 14 doi: 10.1002/pbc.25895. PMID: 26766550
Extraction of mediastinal teratoma contents for complete thoracoscopic resection.
Tsubochi H, Endo S, Nakano T, Minegishi K, Tetsuka K, Hasegawa T
Asian Cardiovasc Thorac Ann 2015 Jan;23(1):42-5. Epub 2014 May 16 doi: 10.1177/0218492314536173. PMID: 24838232
Experience with thoracoscopic resection for mediastinal mature teratoma: a retrospective analysis of 15 patients.
Shintani Y, Funaki S, Nakagiri T, Inoue M, Sawabata N, Minami M, Kadota Y, Okumura M
Interact Cardiovasc Thorac Surg 2013 Apr;16(4):441-4. Epub 2013 Jan 3 doi: 10.1093/icvts/ivs543. PMID: 23287591Free PMC Article
Primary mediastinal germ cell tumors in children and adolescents: results of the German cooperative protocols MAKEI 83/86, 89, and 96.
Schneider DT, Calaminus G, Reinhard H, Gutjahr P, Kremens B, Harms D, Göbel U
J Clin Oncol 2000 Feb;18(4):832-9. doi: 10.1200/JCO.2000.18.4.832. PMID: 10673525

Prognosis

Prenatal ultrasonic features of a mediastinal teratoma: A case report and literature review.
Xu L, Ma Q, Tian X, Huang W, Zhong W, Shang N
J Clin Ultrasound 2022 Sep;50(7):1004-1012. Epub 2022 Apr 8 doi: 10.1002/jcu.23203. PMID: 35394661
Retrosternal goiter in thoracic surgical practice.
Anikin V, Welman K, Asadi N, Dalal P, Reshetov I, Beddow E
Khirurgiia (Mosk) 2021;(12):20-26. doi: 10.17116/hirurgia202112120. PMID: 34941205
Mediastinal masses: a case of fetal teratoma and literature review.
Giancotti A, La Torre R, Bevilacqua E, D'Ambrosio V, Pasquali G, Panici PB
Clin Exp Obstet Gynecol 2012;39(3):384-7. PMID: 23157052
Mediastinal teratoma and trichoptysis.
Guibert N, Attias D, Pontier S, Berjaud J, Lavialle-Guillautreau V, Didier A
Ann Thorac Surg 2011 Jul;92(1):351-3. doi: 10.1016/j.athoracsur.2011.01.036. PMID: 21718876
Management of fetal lung lesions.
Adzick NS
Clin Perinatol 2009 Jun;36(2):363-76, x. doi: 10.1016/j.clp.2009.03.001. PMID: 19559325

Clinical prediction guides

Retrosternal goiter in thoracic surgical practice.
Anikin V, Welman K, Asadi N, Dalal P, Reshetov I, Beddow E
Khirurgiia (Mosk) 2021;(12):20-26. doi: 10.17116/hirurgia202112120. PMID: 34941205
Mediastinal Germ Cell Tumors in Pediatric Patients: A Report From the Italian Association of Pediatric Hematology and Oncology.
De Pasquale MD, Crocoli A, Conte M, Indolfi P, D'Angelo P, Boldrini R, Terenziani M, Inserra A
Pediatr Blood Cancer 2016 May;63(5):808-12. Epub 2016 Jan 14 doi: 10.1002/pbc.25895. PMID: 26766550
A Unique Case of Mediastinal Teratoma with Mature Pancreatic Tissue, Nesidioblastosis, and Aberrant Islet Differentiation: a Case Report and Literature Review.
Agrawal T, Blau AJ, Chwals WJ, Tischler AS
Endocr Pathol 2016 Mar;27(1):21-4. doi: 10.1007/s12022-015-9393-4. PMID: 26318442
Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates.
Ances BM, Vitaliani R, Taylor RA, Liebeskind DS, Voloschin A, Houghton DJ, Galetta SL, Dichter M, Alavi A, Rosenfeld MR, Dalmau J
Brain 2005 Aug;128(Pt 8):1764-77. Epub 2005 May 11 doi: 10.1093/brain/awh526. PMID: 15888538Free PMC Article
Primary mediastinal germ cell tumors in children and adolescents: results of the German cooperative protocols MAKEI 83/86, 89, and 96.
Schneider DT, Calaminus G, Reinhard H, Gutjahr P, Kremens B, Harms D, Göbel U
J Clin Oncol 2000 Feb;18(4):832-9. doi: 10.1200/JCO.2000.18.4.832. PMID: 10673525

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